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The map label for this gene is trpB [H]

Identifier: 162007984

GI number: 162007984

Start: 1570553

End: 1571767

Strand: Direct

Name: trpB [H]

Synonym: ELI_07590

Alternate gene names: 162007984

Gene position: 1570553-1571767 (Clockwise)

Preceding gene: 85374344

Following gene: 85374346

Centisome position: 51.45

GC content: 65.27

Gene sequence:

>1215_bases
GTGGCAACCAAGGCGAATTCCTTCCGCACCCAGCCTGACGAGCGCGGGCATTTCGGCCAGTTCGGTGGGCGCTATGTCGC
TGAAACGCTGATGCCGCTCGTGCTGGACCTAGAGCGCGAATATCGCGCGGCGCAGGCCGATCCTGCCTTTCAGGCCCAAT
TCGACGACCTGCTCGAACACTACGTCGGCCGCCCCTCCCCGCTCTATTTCGCAGAACGCCTCACCGAGGCGCTCGGCGGC
GCGCAGGTCTGGTTCAAACGCGACGAGCTCAACCACACTGGCGCGCATAAGATCAACAATTGCATCGGGCAGATCCTGCT
CGCCGAGCGCATGGGTAAGACCCGCATCATCGCGGAGACCGGCGCGGGGCAACACGGCGTCGCCACCGCCACCGTCTGCG
CGCGGTTCGGCCTGCCTTGCGTCATCTACATGGGCGCGGAGGACGTAAAGCGGCAGTCGCCCAATGTCTTCCGCATGAAG
CTGCTCGGCGCAGAAGTCGTCCCCGTCACCAGCGGCGGCGCGACGCTCAAGGACGCGATGAACGAAGGGCTGCGCGACTG
GGTCGCGAATGTCCACGACACCTTCTACATCATCGGCACCGCCGCCGGGCCGCATCCCTATCCGGAGCTGGTGCGCGATT
TCCAGAGCGTGATCGGCAAGGAAGCCCGCGCGCAAATGCTCGACCGCACGGGCCGCCTGCCCGATTTGCTGATCGCCTGC
ATCGGCGGCGGCTCCAACGCGCTCGGCCTGTTCCACCCGTTTCTTGACGATCCGGACGTGAAGATGCTCGGCGTCGAAGC
GGCGGGCCATGGTCTTGACGGCGACCAGCATGCCGCCAGCCTGCTCGGCGGCGCGCCCGGCATATTGCACGGCAACAAGA
CCTACCTGCTGCAGGACGAGGACGGCCAGATCACCGAAGGCCACTCGATCAGCGCCGGCCTCGACTACCCCGGCATCGGC
CCCGAACACGCATGGCTGAAAGAGTCAGGCCGCGTCGAATACACCGCCGTGACCGATGACGAGGCCTTGGACGGCTTCCA
GCTGCTTTGCCGCACCGAGGGGATTATTCCCGCTCTGGAACCGTCACACGCCATCGCGGCGGTCGCCGACCGCGCCAAAC
AGATGAGCGAGGACCAGATCATCCTGATGAACCTGTGCGGACGCGGGGATAAGGACATCTTCACGGTGGCGGAGAAGCTG
GGAGTGGAGATGTAA

Upstream 100 bases:

>100_bases
TCCCGTTCGCCCTGTGCTTGTCGAAGGGCCGTACTTCTTTTTTACGCTGCGCCAGAAGCAAGAACGGGGCTTCGACAGGC
TCAGCCCGAACGGATTTTTT

Downstream 100 bases:

>100_bases
TGCGTCTACGCCGGGAAGCTGAGAACAAGAATTCAACTGAATGGCCAGCGTTTCATCATCTAATGGATTGCTACTGGCAT
CAAACCGCCGATGCATTTTA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MATKANSFRTQPDERGHFGQFGGRYVAETLMPLVLDLEREYRAAQADPAFQAQFDDLLEHYVGRPSPLYFAERLTEALGG
AQVWFKRDELNHTGAHKINNCIGQILLAERMGKTRIIAETGAGQHGVATATVCARFGLPCVIYMGAEDVKRQSPNVFRMK
LLGAEVVPVTSGGATLKDAMNEGLRDWVANVHDTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLDRTGRLPDLLIAC
IGGGSNALGLFHPFLDDPDVKMLGVEAAGHGLDGDQHAASLLGGAPGILHGNKTYLLQDEDGQITEGHSISAGLDYPGIG
PEHAWLKESGRVEYTAVTDDEALDGFQLLCRTEGIIPALEPSHAIAAVADRAKQMSEDQIILMNLCGRGDKDIFTVAEKL
GVEM

Sequences:

>Translated_404_residues
MATKANSFRTQPDERGHFGQFGGRYVAETLMPLVLDLEREYRAAQADPAFQAQFDDLLEHYVGRPSPLYFAERLTEALGG
AQVWFKRDELNHTGAHKINNCIGQILLAERMGKTRIIAETGAGQHGVATATVCARFGLPCVIYMGAEDVKRQSPNVFRMK
LLGAEVVPVTSGGATLKDAMNEGLRDWVANVHDTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLDRTGRLPDLLIAC
IGGGSNALGLFHPFLDDPDVKMLGVEAAGHGLDGDQHAASLLGGAPGILHGNKTYLLQDEDGQITEGHSISAGLDYPGIG
PEHAWLKESGRVEYTAVTDDEALDGFQLLCRTEGIIPALEPSHAIAAVADRAKQMSEDQIILMNLCGRGDKDIFTVAEKL
GVEM
>Mature_403_residues
ATKANSFRTQPDERGHFGQFGGRYVAETLMPLVLDLEREYRAAQADPAFQAQFDDLLEHYVGRPSPLYFAERLTEALGGA
QVWFKRDELNHTGAHKINNCIGQILLAERMGKTRIIAETGAGQHGVATATVCARFGLPCVIYMGAEDVKRQSPNVFRMKL
LGAEVVPVTSGGATLKDAMNEGLRDWVANVHDTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLDRTGRLPDLLIACI
GGGSNALGLFHPFLDDPDVKMLGVEAAGHGLDGDQHAASLLGGAPGILHGNKTYLLQDEDGQITEGHSISAGLDYPGIGP
EHAWLKESGRVEYTAVTDDEALDGFQLLCRTEGIIPALEPSHAIAAVADRAKQMSEDQIILMNLCGRGDKDIFTVAEKLG
VEM

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=385, Percent_Identity=56.6233766233766, Blast_Score=453, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=57.5520833333333, Blast_Score=471, Evalue=1e-134,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 43688; Mature: 43557

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKANSFRTQPDERGHFGQFGGRYVAETLMPLVLDLEREYRAAQADPAFQAQFDDLLEH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YVGRPSPLYFAERLTEALGGAQVWFKRDELNHTGAHKINNCIGQILLAERMGKTRIIAET
HCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
GAGQHGVATATVCARFGLPCVIYMGAEDVKRQSPNVFRMKLLGAEVVPVTSGGATLKDAM
CCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCCCHHHHHH
NEGLRDWVANVHDTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLDRTGRLPDLLIAC
HHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHEE
IGGGSNALGLFHPFLDDPDVKMLGVEAAGHGLDGDQHAASLLGGAPGILHGNKTYLLQDE
ECCCCCCCHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEECCEEEEEECC
DGQITEGHSISAGLDYPGIGPEHAWLKESGRVEYTAVTDDEALDGFQLLCRTEGIIPALE
CCCEECCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCC
PSHAIAAVADRAKQMSEDQIILMNLCGRGDKDIFTVAEKLGVEM
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATKANSFRTQPDERGHFGQFGGRYVAETLMPLVLDLEREYRAAQADPAFQAQFDDLLEH
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YVGRPSPLYFAERLTEALGGAQVWFKRDELNHTGAHKINNCIGQILLAERMGKTRIIAET
HCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEC
GAGQHGVATATVCARFGLPCVIYMGAEDVKRQSPNVFRMKLLGAEVVPVTSGGATLKDAM
CCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCCCHHHHHH
NEGLRDWVANVHDTFYIIGTAAGPHPYPELVRDFQSVIGKEARAQMLDRTGRLPDLLIAC
HHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHEE
IGGGSNALGLFHPFLDDPDVKMLGVEAAGHGLDGDQHAASLLGGAPGILHGNKTYLLQDE
ECCCCCCCHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEECCEEEEEECC
DGQITEGHSISAGLDYPGIGPEHAWLKESGRVEYTAVTDDEALDGFQLLCRTEGIIPALE
CCCEECCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCC
PSHAIAAVADRAKQMSEDQIILMNLCGRGDKDIFTVAEKLGVEM
CCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA