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The map label for this gene is uppS [H]

Identifier: 161870877

GI number: 161870877

Start: 2016899

End: 2017672

Strand: Direct

Name: uppS [H]

Synonym: NMCC_1966

Alternate gene names: 161870877

Gene position: 2016899-2017672 (Clockwise)

Preceding gene: 161870876

Following gene: 161870878

Centisome position: 93.66

GC content: 54.13

Gene sequence:

>774_bases
TTGAATGCCGAACCGCGAAAGGCAGACATGAAAAGCAGCACGCAGGCCGTTTTGGAACACACCGCCATTCCCAAGCATAT
CGCCGTGATTATGGACGGCAACGGCCGTTGGGCGAAAAAACGTTTCCTCCCGCGCATAATGGGACACAAACGCGGTTTGG
ACGCATTGGAAAATATGGTGAAGCATTGCGCCAAACTGGGTGTGCAATATCTGACCGTGTTTGCCTTTTCAACCGAAAAC
TGGCGCCGCCCCGAAGACGAAGTTTCGTTCCTGATGGGGCTGTTTTTACAGGCTTTGCAAAAACAGGTACGCCGCCTGCA
CGAAAACAATATGCGCCTGAAAATACTGGGCAGCCGCGAACGCTTCAGCCGTCAAATCCTGAAGGGCATCGAAGAGGCGG
AGGCGTTGACGGCAAACAATACCGGTCTGACCCTGAGCATTGCCGCCGATTACGGCGGCAGATGGGACATTTTGCAGGCG
GCAAACAAACTGATTGCCAAAGGCGTATCCGAGATTACGGAAGACACGCTGGCGAAACACTTGATGCTGGGCGATGCGCC
CGAGCCGGATTTGTTCATCCGCACCGGCGGCGAAACGCGCATCAGCAATTTCCTACTCTGGCAAATGGCTTATGCCGAAC
TGTATTTCACCGATATTTTGTGGCCCGATTTTGACGGCAAGGCTTTGGACGATGCCGTCGCTTCGTTCCAAAAACGCGAA
CGGCGGTTCGGACGCACCTCCGAGCAACTGCCTATCGAACAGCAAAGGAACTGA

Upstream 100 bases:

>100_bases
CTGACCGACAAATACATTACCGAAGCCGACAAACTCCTGACTGCCAAAGAAGAAGATTTGATGGCAATTTAACCTGCACG
GTTCGGCGTTCAGACGGCAT

Downstream 100 bases:

>100_bases
ATATGCTGAAACAACGGGTAATAACCGCCATGTGGCTGCTGCCGCTGATGCTGGGCATGCTGTTTTACGCGCCGCAATGG
TTGTGGGCTGCATTTTGCGG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNAEPRKADMKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMVKHCAKLGVQYLTVFAFSTEN
WRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRERFSRQILKGIEEAEALTANNTGLTLSIAADYGGRWDILQA
ANKLIAKGVSEITEDTLAKHLMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRE
RRFGRTSEQLPIEQQRN

Sequences:

>Translated_257_residues
MNAEPRKADMKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMVKHCAKLGVQYLTVFAFSTEN
WRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRERFSRQILKGIEEAEALTANNTGLTLSIAADYGGRWDILQA
ANKLIAKGVSEITEDTLAKHLMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRE
RRFGRTSEQLPIEQQRN
>Mature_257_residues
MNAEPRKADMKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMVKHCAKLGVQYLTVFAFSTEN
WRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRERFSRQILKGIEEAEALTANNTGLTLSIAADYGGRWDILQA
ANKLIAKGVSEITEDTLAKHLMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRE
RRFGRTSEQLPIEQQRN

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=230, Percent_Identity=34.7826086956522, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI45580738, Length=230, Percent_Identity=34.7826086956522, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786371, Length=245, Percent_Identity=51.0204081632653, Blast_Score=247, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.283185840708, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=210, Percent_Identity=35.7142857142857, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=32.1100917431193, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=34.8017621145374, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29330; Mature: 29330

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAEPRKADMKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMV
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KHCAKLGVQYLTVFAFSTENWRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRE
HHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
RFSRQILKGIEEAEALTANNTGLTLSIAADYGGRWDILQAANKLIAKGVSEITEDTLAKH
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRE
HHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RRFGRTSEQLPIEQQRN
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAEPRKADMKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMV
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHH
KHCAKLGVQYLTVFAFSTENWRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRE
HHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
RFSRQILKGIEEAEALTANNTGLTLSIAADYGGRWDILQAANKLIAKGVSEITEDTLAKH
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRE
HHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RRFGRTSEQLPIEQQRN
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA