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The map label for this gene is nuoI

Identifier: 161870814

GI number: 161870814

Start: 1944573

End: 1945052

Strand: Reverse

Name: nuoI

Synonym: NMCC_1896

Alternate gene names: 161870814

Gene position: 1945052-1944573 (Counterclockwise)

Preceding gene: 161870815

Following gene: 161870813

Centisome position: 90.32

GC content: 52.5

Gene sequence:

>480_bases
ATGGCTAACTTAGTAAAAACCTTTCTGCTTGGCGAATTGGTAAAAGGTATGGGCGTAACGCTCAAAAACTTTTTCGCCCG
CAAAGACACGATTTATTTTCCTGAAGAGAAAACGCCGCAATCCGTGCGTTTCCGCGGCCTGCACGCGCAGCGGCGGTATC
CGAACGGTGAGGAACGCTGCATTGCGTGTAAGTTGTGCGAGGCGGTGTGTCCGGCAATGGCGATCAATATCGAATCGGAA
GAACGCGAAGACGGCACCCGCCGCACCAAGCGTTACGACATCGACCTGACCAAGTGCATCTTCTGCGGTTTCTGCGAAGA
GGCTTGCCCGACCGATGCGATTGTGGAAACGCACATTTTTGAATACCACGGCGAGAAAAAAGGCGACTTGCACATGACCA
AGCCGATTCTTTTGGCCATTGGCGACAAATACGAAGCTGAAATCGCCAAACGCAAAGCCGCTGACGCGCCGTATCGTTAA

Upstream 100 bases:

>100_bases
CGCTGAATTTGTGGAAATAAGTTTCAGACGGCATCTTGAGGCCGTCTGAACAAAGCGATTTTGAATACCTAACGAAATCC
CTGTTTTGAGGGAACATAAT

Downstream 100 bases:

>100_bases
GGAGCAGACGAATGACTTTTTCCACGATTCTGTTCTATATCCTTGCCGCCATCGTTTTGTACGGTGCGGTTCGTACCGTC
ACCGCTAAAAACCCTGTCCA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MANLVKTFLLGELVKGMGVTLKNFFARKDTIYFPEEKTPQSVRFRGLHAQRRYPNGEERCIACKLCEAVCPAMAINIESE
EREDGTRRTKRYDIDLTKCIFCGFCEEACPTDAIVETHIFEYHGEKKGDLHMTKPILLAIGDKYEAEIAKRKAADAPYR

Sequences:

>Translated_159_residues
MANLVKTFLLGELVKGMGVTLKNFFARKDTIYFPEEKTPQSVRFRGLHAQRRYPNGEERCIACKLCEAVCPAMAINIESE
EREDGTRRTKRYDIDLTKCIFCGFCEEACPTDAIVETHIFEYHGEKKGDLHMTKPILLAIGDKYEAEIAKRKAADAPYR
>Mature_158_residues
ANLVKTFLLGELVKGMGVTLKNFFARKDTIYFPEEKTPQSVRFRGLHAQRRYPNGEERCIACKLCEAVCPAMAINIESEE
REDGTRRTKRYDIDLTKCIFCGFCEEACPTDAIVETHIFEYHGEKKGDLHMTKPILLAIGDKYEAEIAKRKAADAPYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=155, Percent_Identity=60.6451612903226, Blast_Score=189, Evalue=8e-49,
Organism=Escherichia coli, GI1788617, Length=139, Percent_Identity=40.2877697841727, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555194, Length=155, Percent_Identity=56.7741935483871, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17864306, Length=155, Percent_Identity=60.6451612903226, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_NEIG1 (Q5F623)

Other databases:

- EMBL:   AE004969
- RefSeq:   YP_208776.1
- HSSP:   P00198
- ProteinModelPortal:   Q5F623
- SMR:   Q5F623
- STRING:   Q5F623
- EnsemblBacteria:   EBNEIT00000002354
- GeneID:   3281187
- GenomeReviews:   AE004969_GR
- KEGG:   ngo:NGO1743
- eggNOG:   COG1143
- GeneTree:   EBGT00050000020569
- HOGENOM:   HBG724359
- OMA:   NKAADAP
- PhylomeDB:   Q5F623
- ProtClustDB:   PRK05888
- BioCyc:   NGON242231:NGO1743-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- InterPro:   IPR015880
- Gene3D:   G3DSA:1.10.1060.10
- SMART:   SM00355
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18156; Mature: 18025

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2; PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLVKTFLLGELVKGMGVTLKNFFARKDTIYFPEEKTPQSVRFRGLHAQRRYPNGEERC
CHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHCCCCCCCHHH
IACKLCEAVCPAMAINIESEEREDGTRRTKRYDIDLTKCIFCGFCEEACPTDAIVETHIF
HHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
EYHGEKKGDLHMTKPILLAIGDKYEAEIAKRKAADAPYR
HHCCCCCCCEEECCCEEEEECCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ANLVKTFLLGELVKGMGVTLKNFFARKDTIYFPEEKTPQSVRFRGLHAQRRYPNGEERC
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHCCCCCCCHHH
IACKLCEAVCPAMAINIESEEREDGTRRTKRYDIDLTKCIFCGFCEEACPTDAIVETHIF
HHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
EYHGEKKGDLHMTKPILLAIGDKYEAEIAKRKAADAPYR
HHCCCCCCCEEECCCEEEEECCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA