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The map label for this gene is farA [H]

Identifier: 161870752

GI number: 161870752

Start: 1868223

End: 1869377

Strand: Reverse

Name: farA [H]

Synonym: NMCC_1826

Alternate gene names: 161870752

Gene position: 1869377-1868223 (Counterclockwise)

Preceding gene: 161870755

Following gene: 161870751

Centisome position: 86.81

GC content: 60.35

Gene sequence:

>1155_bases
ATGGATACGCACACGGACGAAACAAAACTTCAAAACACGCAAGCCAAACGCAAACGCTGCCTGACGGCATTGACGCTGCT
GTTCGCGCTTGCCGCCGCAGCCGCCGGGTCGGCGTTTTTTTTATGGTGGCAGCACGAAGAGGAAACGGAAGACGCTTATG
TTGCCGGACGCGTGGTTCAGGTTACGCCGCAAAAGGGCGGTACGGTGCGGAAGGTTTTGCACGACGATACGGATGCCGTG
AAAAAAGGCGACGTGCTGGCGGTATTGGACGACGATAATGATGTGCTGGCTTACGAGCGGGCAAAAAACGAGCTGATTCA
GGCGGTGCGGCAAAACCGCCGGCAAAATGCCGCCACTTCGCAGGCGGGGGCGCAGGTTGCCTTGCGCCGGGCGGATTTGG
CACGTGCGCAGGATGATTTGCGCCGCCGGTCTGCTTTGGCGGAATCGGGCGCGGTGTCCGCCGAAGAGCTGGCACATGCC
CGTGCGGCAGTGTCTCAGGCTCAGGCGGCGGTCAAAGCGGCTTTGGCGGAAGAATCTTCGGCACGCGCGGCTTTGGGCGG
TCAGGTTTCTTTGCGCGAACAGCCGGCGGTTCAGACGGCAATCGGCAGGTTGAAAGATGCGTGGTTGAACCTTCAGCGGA
CGCAAATCCGCGCGCCGGCGGACGGTCAGGTGGCGAAGCGTTCGGTGCAGGTCGGGCAGCAGGTGGCGGCAGGCGCGCCG
CTGATGGCGGTGGTGCCGCTGTCGGATGTGTGGGTGGATGCCAATTTTAAAGAGACGCAGTTGCGGCATATGAAAATCGG
ACAGCCTGCCGAACTGGTGTCCGATTTGTACGGCAAACAAATTGTTTATCGCGGCAGGGTGGCAGGGTTTTCGGCAGGTA
CGGGCAGCGCGTTTTCGCTGATTCCGGCGCAAAACGCAACGGGCAACTGGATTAAAGTGGTGCAGCGCGTCCCCGTCCGT
ATCGTGCTGAACCGCGAAGATGTGGACAGGCATCCGTTGCGTATCGGTTTGTCGATGACGGTTAAAGTGGATACTTCCGC
CGCAGGCGCGCCTGTTTCAAAAACGCCGGGTGCGGCATTGCCGGAAATGGAAAGTACCGACTGGTCGGAAGTCGATCGGA
CGGTCGATGAAATCCTCGGGCAATCCGCGCCCTGA

Upstream 100 bases:

>100_bases
TAAAATACTGACTTGATTGCGTTATTGCGCGGATATAGAATCTGCCTCCTATTGAAAGAACATTGTTTATATGAAATCAG
GAAATTCGGAACCCAATCTT

Downstream 100 bases:

>100_bases
TGCCGTCTGAAACGGAGGACACAATGGATTATCCACCGCTTAAGGGTGCGGCATTGGCGTGGGTTACGCTGTCTTTGGGG
CTTGCCGTATTTATGGAAGT

Product: fatty acid efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDTHTDETKLQNTQAKRKRCLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAV
KKGDVLAVLDDDNDVLAYERAKNELIQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHA
RAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAP
LMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVR
IVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP

Sequences:

>Translated_384_residues
MDTHTDETKLQNTQAKRKRCLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAV
KKGDVLAVLDDDNDVLAYERAKNELIQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHA
RAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAP
LMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVR
IVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP
>Mature_384_residues
MDTHTDETKLQNTQAKRKRCLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAV
KKGDVLAVLDDDNDVLAYERAKNELIQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHA
RAAVSQAQAAVKAALAEESSARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAP
LMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVR
IVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAALPEMESTDWSEVDRTVDEILGQSAP

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=373, Percent_Identity=45.8445040214477, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1788711, Length=357, Percent_Identity=42.296918767507, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI1790519, Length=316, Percent_Identity=31.3291139240506, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87081951, Length=306, Percent_Identity=29.0849673202614, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789637, Length=324, Percent_Identity=26.2345679012346, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790024, Length=268, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790012, Length=246, Percent_Identity=27.2357723577236, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787013, Length=268, Percent_Identity=28.7313432835821, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41284; Mature: 41284

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTHTDETKLQNTQAKRKRCLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCEEEE
VTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELIQAVRQNRRQNAATS
ECCCCCCHHHHHHHCCHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
QAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAP
CHHHCCCCEEECCCCHHHHHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHHHHHHHCCCC
LMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSL
EEEEEECCCEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEE
IPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAAL
EECCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCC
PEMESTDWSEVDRTVDEILGQSAP
CCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDTHTDETKLQNTQAKRKRCLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCEEEE
VTPQKGGTVRKVLHDDTDAVKKGDVLAVLDDDNDVLAYERAKNELIQAVRQNRRQNAATS
ECCCCCCHHHHHHHCCHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
QAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAP
CHHHCCCCEEECCCCHHHHHHHHHHHHHHCHHHHEECCCCCCHHHHHHHHHHHHHHCCCC
LMAVVPLSDVWVDANFKETQLRHMKIGQPAELVSDLYGKQIVYRGRVAGFSAGTGSAFSL
EEEEEECCCEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEE
IPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAAL
EECCCCCCHHHHHHHHCCEEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCC
PEMESTDWSEVDRTVDEILGQSAP
CCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]