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The map label for this gene is farB [H]

Identifier: 161870751

GI number: 161870751

Start: 1866673

End: 1868199

Strand: Reverse

Name: farB [H]

Synonym: NMCC_1825

Alternate gene names: 161870751

Gene position: 1868199-1866673 (Counterclockwise)

Preceding gene: 161870752

Following gene: 161870750

Centisome position: 86.76

GC content: 53.44

Gene sequence:

>1527_bases
ATGGATTATCCACCGCTTAAGGGTGCGGCATTGGCGTGGGTTACGCTGTCTTTGGGGCTTGCCGTATTTATGGAAGTTTT
AGATACGACTATCGCCAATGTCGCCGTTCCCGTCATCGCCGGCAACCTCGGTGCGGCAACCACGCAGGGGACGTGGGTCA
TTACTTCTTTTGCTGTGGCAAACGCCGTTTCCGTGCCGTTAACGGGCTTTTTGGCAAAACGTATCGGCGAGGTCAAACTG
TTTACCGCCGCCGCTGTCGGTTTCGTCATCACATCATGGCTGTGCGGCATCGCGCCCAACCTTCAGGCTTTGGTGTTTTT
CCGCATCTTGCAGGGTTTTATCGCCGGGCCGCTGATTCCCCTGTCGCAAAGCCTGTTAATGGCATCCTATCCGCCCGCAA
AACGGACGCTGGCACTGGCATTGTGGGCAATGACCGTCGTTGTCGCCCCTGTTCTCGGGCCGATATTCGGCGGCTGGATT
TCCGGAAACTGGCATTGGGGTTGGATTTTCTTCATTAATATCCCTATCGGTATCATATCGGCATGGATTACATGGAAACA
TTTGAAATATCGGGAAACGGAAACCGTTAAAATGCCGACCGACTATGTCGGGCTTACATTGATGGTAGTCGGTATCGGCG
CGTTACAGATGATGCTGGACAGGGGTAAGGAACTCGACTGGTTCGCTTCGGGAGAAATCATTACCTTGGGCGTAACCGCA
CTGGTGTGCTTGTCGTATTTTATTGTTTGGGAATTGGGAGAAAAATATCCGATTGTCGATTTATCGCTGTTTAAAGATCG
GAATTTTACCGTCGGCATCATTGCCACATCATTGGGTTTTATGGTGTATATGGGGACGCTGACCCTGCTGCCGTTAGTGT
TGCAGACCAACCTGGGCTATACCTCCACGTGGGCGGGGCTTGCCGCCGCACCCGTCGGCATCCTGCCCGTCTTCCTGTCT
CCGTTAATCGGCAGGTTCGGCAATAAAATCGATATGCGCCTGCTCGTAACCGCCAGCTTCCTGACTTTTGCCTTCACTTT
CTATTGGCGCACCGATTTTTATGCCGACATGGATATCGGCAACGTCATCTGGCCGCAGTTTTGGCAGGGAGTAGGCGTTG
CCATGTTCTTCCTGCCGCTGACCACCATCACACTGTCGCACATGAAGGGCGGACAGATTGCCGCCGCCGGCAGCCTGTCG
AATTTCCTGCGCGTGCTGATGGGCGGTGTCGGCGTATCCGTCGTTAGTACCCTGTGGGAACGGCGTGAAGCGTTGCACCA
TACACGCTTTGCCGAACACATCACGCCCTATTCCGCAACATTGCACGAAACGGCCGCTCATTTGTCCCAGCACGGCGTTT
CCGACATTCAAACCCTAGGCATCATCAACAATACCATTACCCAGCAGGGTTTTATTATCGGCTCGAACGAAATCTTTATG
GCGGGCAGCTTGTTATTCATTATCATGATACCCGTCATATGGCTGGCAAAACCGCCGTTCCACAACGGCGGCGGCGGTGG
ACATTGA

Upstream 100 bases:

>100_bases
TGCCGGAAATGGAAAGTACCGACTGGTCGGAAGTCGATCGGACGGTCGATGAAATCCTCGGGCAATCCGCGCCCTGATGC
CGTCTGAAACGGAGGACACA

Downstream 100 bases:

>100_bases
GGGATTTGAAAACTTGAAATGCCGTCTGAAAATACTGGAAATATGTTCGGACGGCATTTTGAATGCAGCAGTTCCCGAAA
TCCGCTATAATCGCGCCCCA

Product: fatty acid efflux system protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVANAVSVPLTGFLAKRIGEVKL
FTAAAVGFVITSWLCGIAPNLQALVFFRILQGFIAGPLIPLSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPIFGGWI
SGNWHWGWIFFINIPIGIISAWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVTA
LVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGYTSTWAGLAAAPVGILPVFLS
PLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIGNVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLS
NFLRVLMGGVGVSVVSTLWERREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFM
AGSLLFIIMIPVIWLAKPPFHNGGGGGH

Sequences:

>Translated_508_residues
MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVANAVSVPLTGFLAKRIGEVKL
FTAAAVGFVITSWLCGIAPNLQALVFFRILQGFIAGPLIPLSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPIFGGWI
SGNWHWGWIFFINIPIGIISAWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVTA
LVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGYTSTWAGLAAAPVGILPVFLS
PLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIGNVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLS
NFLRVLMGGVGVSVVSTLWERREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFM
AGSLLFIIMIPVIWLAKPPFHNGGGGGH
>Mature_508_residues
MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVANAVSVPLTGFLAKRIGEVKL
FTAAAVGFVITSWLCGIAPNLQALVFFRILQGFIAGPLIPLSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPIFGGWI
SGNWHWGWIFFINIPIGIISAWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVTA
LVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGYTSTWAGLAAAPVGILPVFLS
PLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIGNVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLS
NFLRVLMGGVGVSVVSTLWERREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFM
AGSLLFIIMIPVIWLAKPPFHNGGGGGH

Specific function: Translocase that confers resistance to substances of high hydrophobicity [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=497, Percent_Identity=57.1428571428571, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1788710, Length=503, Percent_Identity=51.2922465208747, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1790195, Length=439, Percent_Identity=28.9293849658314, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081983, Length=382, Percent_Identity=26.9633507853403, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788392, Length=403, Percent_Identity=27.7915632754342, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322958, Length=182, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55174; Mature: 55174

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHH
NAVSVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQALVFFRILQGFIAGPLIP
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
LSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPIFGGWISGNWHWGWIFFINIPIGIIS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEEEEEECCHHHHH
AWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVTA
HHHHHHHHEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEHHHHH
LVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGY
HHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSTWAGLAAAPVGILPVFLSPLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEECCCCC
NVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHH
RREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCEEH
AGSLLFIIMIPVIWLAKPPFHNGGGGGH
HHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDYPPLKGAALAWVTLSLGLAVFMEVLDTTIANVAVPVIAGNLGAATTQGTWVITSFAVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHH
NAVSVPLTGFLAKRIGEVKLFTAAAVGFVITSWLCGIAPNLQALVFFRILQGFIAGPLIP
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCH
LSQSLLMASYPPAKRTLALALWAMTVVVAPVLGPIFGGWISGNWHWGWIFFINIPIGIIS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEEEEEECCHHHHH
AWITWKHLKYRETETVKMPTDYVGLTLMVVGIGALQMMLDRGKELDWFASGEIITLGVTA
HHHHHHHHEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEHHHHH
LVCLSYFIVWELGEKYPIVDLSLFKDRNFTVGIIATSLGFMVYMGTLTLLPLVLQTNLGY
HHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSTWAGLAAAPVGILPVFLSPLIGRFGNKIDMRLLVTASFLTFAFTFYWRTDFYADMDIG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCEEECCCCC
NVIWPQFWQGVGVAMFFLPLTTITLSHMKGGQIAAAGSLSNFLRVLMGGVGVSVVSTLWE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHH
RREALHHTRFAEHITPYSATLHETAAHLSQHGVSDIQTLGIINNTITQQGFIIGSNEIFM
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCEEH
AGSLLFIIMIPVIWLAKPPFHNGGGGGH
HHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]