Click here to switch to the map view.

The map label for this gene is fabI

Identifier: 161870734

GI number: 161870734

Start: 1852481

End: 1853266

Strand: Reverse

Name: fabI

Synonym: NMCC_1807

Alternate gene names: 161870734

Gene position: 1853266-1852481 (Counterclockwise)

Preceding gene: 161870735

Following gene: 161870731

Centisome position: 86.06

GC content: 58.02

Gene sequence:

>786_bases
ATGGGTTTTCTGCAAGGCAAAAAAATTCTGATTACCGGCATGATTTCCGAGCGTTCCATCGCTTACGGCATCGCCAAAGC
CTGCCGCGAACAAGGCGCGGAACTGGCGTTTACCTACGTTGTGGACAAACTGGAAGAGCGCGTCCGCAAAATGGCGGCGG
AATTGGATTCCGAACTCGTGTTCCGCTGCGATGTCGCCAGCGACGACGAAATCAACCAAGTGTTCGCCGACTTGGGCAAG
CATTGGGACGGCTTGGACGGTTTGGTGCATTCCATCGGCTTCGCGCCGAAAGAAGCCTTGAGCGGCGATTTCCTCGACAG
CATCAGCCGCGAAGCGTTCAACACCGCACACGAAATTTCCGCATACAGCCTGCCTGCGCTGGCAAAAGCCGCCCGTCCGA
TGATGCGCGGCAGAAACTCCGCCATCGTCGCCCTGAGCTACTTGGGCGCGGTGCGCGCGATTCCGAACTACAACGTGATG
GGTATGGCAAAAGCTAGCCTTGAGGCAGGCATCCGCTTTACCGCCGCCTGTTTGGGCAAAGAAGGCATCCGCTGCAACGG
CATTTCCGCCGGTCCGATCAAAACACTCGCCGCCTCCGGCATCGCCGATTTTGGCAAACTCTTGGGACACGTCGCCGCCC
ACAATCCGCTGCGCCGCAACGTTACCATCGAAGAAGTCGGCAATACCGCCGCCTTCCTGCTGTCCGACCTGTCGTCCGGC
ATTACCGGCGAAATCACTTACGTTGACGGCGGTTACAGCATTAATGCCTTGAGCACCGAGGGATAA

Upstream 100 bases:

>100_bases
CATTGCCGTTTGCATGCTGCAACGTGAAAACACAGAAACAGGGACAATTTGCTATAATCAACGGTTTAGAACGAACCGAA
CACTATTTGAAGGATACAAA

Downstream 100 bases:

>100_bases
TCCGCCGTTTTCAAATCCGTGCGCCGTCCGTGCCGCATATCGGTTTCGGGCGGCGGTTTGCCGTCTGAAGCGTATTTCCA
GAGAAATGCCCGACTTGCGG

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFRCDVASDDEINQVFADLGK
HWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVM
GMAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSG
ITGEITYVDGGYSINALSTEG

Sequences:

>Translated_261_residues
MGFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFRCDVASDDEINQVFADLGK
HWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVM
GMAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSG
ITGEITYVDGGYSINALSTEG
>Mature_260_residues
GFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELVFRCDVASDDEINQVFADLGKH
WDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMG
MAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSGI
TGEITYVDGGYSINALSTEG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily

Homologues:

Organism=Homo sapiens, GI7705925, Length=262, Percent_Identity=29.0076335877863, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=60.8527131782946, Blast_Score=322, Evalue=1e-89,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=29.5880149812734, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=257, Percent_Identity=29.1828793774319, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): FABI_NEIMB (Q9K151)

Other databases:

- EMBL:   AE002098
- PIR:   C81211
- RefSeq:   NP_273385.1
- HSSP:   O24990
- ProteinModelPortal:   Q9K151
- SMR:   Q9K151
- EnsemblBacteria:   EBNEIT00000009419
- GeneID:   902451
- GenomeReviews:   AE002098_GR
- KEGG:   nme:NMB0336
- TIGR:   NMB0336
- GeneTree:   EBGT00050000021389
- HOGENOM:   HBG750976
- OMA:   LVHCLAF
- ProtClustDB:   PRK08690
- BioCyc:   NMEN122586:NMB_0336-MONOMER
- BRENDA:   1.3.1.9
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PANTHER:   PTHR19410:SF12
- PIRSF:   PIRSF000094
- PRINTS:   PR00081

Pfam domain/function: PF00106 adh_short

EC number: =1.3.1.9

Molecular weight: Translated: 27691; Mature: 27560

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: ACT_SITE 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELV
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
FRCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEIS
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHH
AYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHCC
EGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHCCHHHHHHHHHCCC
ITGEITYVDGGYSINALSTEG
CCEEEEEECCCEEEEEECCCC
>Mature Secondary Structure 
GFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKMAAELDSELV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
FRCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEIS
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHH
AYSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGK
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHCC
EGIRCNGISAGPIKTLAASGIADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSG
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHCCHHHHHHHHHCCC
ITGEITYVDGGYSINALSTEG
CCEEEEEECCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307