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The map label for this gene is putP [H]

Identifier: 161870671

GI number: 161870671

Start: 1787155

End: 1788525

Strand: Direct

Name: putP [H]

Synonym: NMCC_1743

Alternate gene names: 161870671

Gene position: 1787155-1788525 (Clockwise)

Preceding gene: 161870665

Following gene: 229597115

Centisome position: 82.99

GC content: 56.46

Gene sequence:

>1371_bases
ATGTCCGGCTGGCTGCTGATGGGTCTGCCGGGCGCGATTTACCTGAGCGGTTTGAATGAGGCTTGGATTGCCATCGGCCT
CTTGGTCGGCGCGTATTTCAACTGGCTCTTGGTGGCGGGCCGCCTGCGCGTGCATACCGAATACGCCAACAATGCGCTGA
CGCTGCCGGATTATTTCTTCCACCGCTTCGGCGCGGGCGGACACTTGATGAAAGTGGTTTCCGCACTGATTATCCTGTTC
TTCTTCACGATTTATTGCGCCTCGGGCATTGTGGCGGGCGCAACCCTGTTCCAAAGCCTGTTTGAAGGTATGACTTACAA
TCAGGCAATGTGGCTGGGCGCGGGCGCGACCATCGCCTATACCTTCTTGGGCGGTTTCTTGGCGGTCAGCTGGACGGATA
CGCTGCAGGCTTCTTTGATGATTTTCGCCCTGATTTTAACGCCGGTGATGGTCTATCTGGGCTTGGGCGGCGCGGAACAG
ATGTCTGCCGCGATTCAAAGCGTCGCCGCAGGCACGGGCAAAGAATACGGCAGCCTGTTTGCCGGTACGACCGTCATCGG
CATCATTTCCACCGCCGCATGGGGCTTGGGCTATTTCGGACAGCCGCACATTTTGGCGCGCTTTATGGCGGCCGAAAGCG
CGAAATCGCTGGTATCCGCACGCCGCATCGGCATGACTTGGATGGCGTTGTGCCTTGCGGGCGCGGTGGCGGTCGGTTAT
TTCGGCATTGCGTATTTCGGTGCAAATCCCGACAAAGTTTCTTCTATGAGCGGCAACCACGAACGCATCTTCATCGCGCT
TTCCACCCTGCTGTTCAACCCTTGGATCGCCGGCATCATTTTGAGCGCGATTTTGGCGGCGGTGATGTCCACCCTGTCCT
GCCAGCTTTTGGTTTGCTCCAGCGCGATTACCGAAGACTTCTACAAAGGCTTTTTGCGTAAAAACGCGCAACAGTCGGAA
CTGGTATGGGTCGGCCGCCTGATGGTCTTGGCGATTGCCGTGATTTCCATCCTGATTGCTTCCGATCCGAACAGCAAAGT
ATTGGGACTGGTGTCTTACGCGTGGGCAGGTTTCGGTGCGGCATTCGGCCCGATTGTGATTCTGTCCGTATTGTGGAAAC
GCATCACTGCCTACGGCGCGTTGTCGGGTATGGTTGCAGGTGCCTTAACCGTGGTCGTATGGGCGGAATGGGTGAAAAAA
CCGGCTCAAGCGGCAGGCGAAAGCGGCTTGTTGACGATGTACGAAATCGTCCCGGGCTTTATTGTTTGCTTGATCGTTGC
CGTGTTGGTTTCCCTGTTCAACAAAGAACCTTCGCGCGAAACCCAAGAACGCTTTGAAAAAGCCGACGCAGATTACCGCG
CCGCCCGATAA

Upstream 100 bases:

>100_bases
GCTTGCCGCCTATTTTTCTACGCGCAATTTCGACGATTACATTTTGGGCGGGCGCAGCCTGGGCCCGTTTGTTACCGCGA
TGTCGGCAGGCGCGTCCGAT

Downstream 100 bases:

>100_bases
ACCCCTTTCAGACGGCACGGCATCCCGGTTCGTGCCGTCTGAACCCGTTTCCGGGTCAAACACAAATAAACCTTGCCTGC
ATACAGGCCTTATTTGTGTT

Product: sodium/proline symporter

Products: NA

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSGWLLMGLPGAIYLSGLNEAWIAIGLLVGAYFNWLLVAGRLRVHTEYANNALTLPDYFFHRFGAGGHLMKVVSALIILF
FFTIYCASGIVAGATLFQSLFEGMTYNQAMWLGAGATIAYTFLGGFLAVSWTDTLQASLMIFALILTPVMVYLGLGGAEQ
MSAAIQSVAAGTGKEYGSLFAGTTVIGIISTAAWGLGYFGQPHILARFMAAESAKSLVSARRIGMTWMALCLAGAVAVGY
FGIAYFGANPDKVSSMSGNHERIFIALSTLLFNPWIAGIILSAILAAVMSTLSCQLLVCSSAITEDFYKGFLRKNAQQSE
LVWVGRLMVLAIAVISILIASDPNSKVLGLVSYAWAGFGAAFGPIVILSVLWKRITAYGALSGMVAGALTVVVWAEWVKK
PAQAAGESGLLTMYEIVPGFIVCLIVAVLVSLFNKEPSRETQERFEKADADYRAAR

Sequences:

>Translated_456_residues
MSGWLLMGLPGAIYLSGLNEAWIAIGLLVGAYFNWLLVAGRLRVHTEYANNALTLPDYFFHRFGAGGHLMKVVSALIILF
FFTIYCASGIVAGATLFQSLFEGMTYNQAMWLGAGATIAYTFLGGFLAVSWTDTLQASLMIFALILTPVMVYLGLGGAEQ
MSAAIQSVAAGTGKEYGSLFAGTTVIGIISTAAWGLGYFGQPHILARFMAAESAKSLVSARRIGMTWMALCLAGAVAVGY
FGIAYFGANPDKVSSMSGNHERIFIALSTLLFNPWIAGIILSAILAAVMSTLSCQLLVCSSAITEDFYKGFLRKNAQQSE
LVWVGRLMVLAIAVISILIASDPNSKVLGLVSYAWAGFGAAFGPIVILSVLWKRITAYGALSGMVAGALTVVVWAEWVKK
PAQAAGESGLLTMYEIVPGFIVCLIVAVLVSLFNKEPSRETQERFEKADADYRAAR
>Mature_455_residues
SGWLLMGLPGAIYLSGLNEAWIAIGLLVGAYFNWLLVAGRLRVHTEYANNALTLPDYFFHRFGAGGHLMKVVSALIILFF
FTIYCASGIVAGATLFQSLFEGMTYNQAMWLGAGATIAYTFLGGFLAVSWTDTLQASLMIFALILTPVMVYLGLGGAEQM
SAAIQSVAAGTGKEYGSLFAGTTVIGIISTAAWGLGYFGQPHILARFMAAESAKSLVSARRIGMTWMALCLAGAVAVGYF
GIAYFGANPDKVSSMSGNHERIFIALSTLLFNPWIAGIILSAILAAVMSTLSCQLLVCSSAITEDFYKGFLRKNAQQSEL
VWVGRLMVLAIAVISILIASDPNSKVLGLVSYAWAGFGAAFGPIVILSVLWKRITAYGALSGMVAGALTVVVWAEWVKKP
AQAAGESGLLTMYEIVPGFIVCLIVAVLVSLFNKEPSRETQERFEKADADYRAAR

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=450, Percent_Identity=48, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1787251, Length=455, Percent_Identity=63.5164835164835, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1790503, Length=403, Percent_Identity=26.302729528536, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082237, Length=399, Percent_Identity=26.0651629072682, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539284, Length=392, Percent_Identity=26.0204081632653, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533094, Length=434, Percent_Identity=24.6543778801843, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 48723; Mature: 48592

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SGWLLMGLPGAIYLSGLNEAWIAIGLLVGAYFNWLLVAGRLRVHTEYANNALTLPDYFF
CCCEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCCCCHHHHH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HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]