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The map label for this gene is penA [H]

Identifier: 161870661

GI number: 161870661

Start: 1776641

End: 1778290

Strand: Reverse

Name: penA [H]

Synonym: NMCC_1731

Alternate gene names: 161870661

Gene position: 1778290-1776641 (Counterclockwise)

Preceding gene: 161870662

Following gene: 161870660

Centisome position: 82.58

GC content: 55.21

Gene sequence:

>1650_bases
ATGGCAATAGCGGTCTTGTTTGCCGGTCTGATTGCCCGCGGACTGTATCTGCAGACGGTAACGTATAACTTTTTGAAAGA
ACAGGGCGACAACCGGATTGTGCGGACTCAAACATTGCCGGCTACACGCGGTACGGTTTCGGACCGGAACGGTGCGGTTT
TGGCGTTGAGTGCGCCGACGGAGTCCCTGTTTGCCGTGCCTAAAGAGATGAAGGAAATGCCGTCTGCCGCACAATTGGAA
CGCCTGTCCGAGCTTGTCGATGTTCCGATTGATGTTTTGAGGAACAAGCTCGAACAGAAAGGCAAGTCGTTTATCTGGAT
TAAGCGGCAGCTCGATCCCAAGGTTGCCGAAGAGGTCAAAGCCTTGGGTTTGGAAAACTTTGTATTTGAAAAAGAATTAA
AACGCCATTACCCGATGGGCAACCTGTTTGCACACGTCATCGGATTTACCGATATTGACGGCAAAGGTCAGGAAGGTTTG
GAACTTTCGCTTGAAGACAGCCTGCATGGCGAAGACGGCGCGGAAGTCGTTTTGCGGGACCGGCAGGGCAATATTGTGGA
CAGCTTGGACTCCCCGCGCAATAAAGCCCCGAAAAACGGCAAAGACATCATCCTTTCCCTCGATCAGAGGATTCAGACCT
TGGCCTATGAAGAGTTGAACAAGGCGGTCGAATACCATCAGGCAAAAGCCGGAACGGTGGTGGTTTTGGATGCCCGCACG
GGGGAAATCCTCGCCTTGGCCAATACGCCCGCCTACGATCCCAACAGGCCCGGCCGGGCAGACAGCGAACAGCGGCGCAA
CCGTGCCGTAACCGATATGATCGAACCCGGTTCGGCAATCAAACCGTTTGTGATTGCGAAAGCATTGGATGCGGGCAAAA
CCGATTTGAACGAACGGCTGAATACGCAGCCTTATAAAATCGGACCGTCTCCCGTGCGCGATACCCATGTTTACCCCTCT
TTGGATGTGCGCGGCATCATGCAGAAATCGTCCAACGTCGGCACAAGCAAACTGTCTGCGCGTTTCGGTGCCGAAGAAAT
GTATGACTTCTATCATGAGTTGGGCATCGGTGTGCGTATGCACTCGGGCTTTCCGGGCGAAACTGCAGGTTTGTTGAGAA
ATTGGCGCAGGTGGCGGCCCATCGAACAGGCGACGATGTCTTTCGGTTACGGCCTGCAATTGAGCCTGCTGCAATTGGCG
CGCGCCTATACCGCACTGACGCACGACGGCGTTTTGCTGCCGGTCAGCTTTGAAAAACAGGCGGTTGCGCCGCAAGGCAA
ACGCATATTCAAAGAATCGACCGCGCGCGAGGTACGCAATCTGATGGTTTCCGTGACCGAGCCGGGCGGCACCGGTACGG
CGGGTGCGGTGGACGGTTTCGATGTCGGCGCGAAAACCGGCACGGCGCGCAAGTTCGTCAACGGGCGTTATGCCGACAAC
AAACACATCGCTACCTTTATCGGTTTTGCCCCCGCCAAAAACCCCCGTGTGATTGTGGCGGTAACCATTGACGAACCGAC
TGCCCACGGTTATTACGGCGGCGTAGTGGCAGGGCCGCCCTTCAAAAAAATTATGGGCGGCAGCCTGAACATCTTGGGCA
TTTCCCCGACCAAGCCACTGACCGCCGCAGCCGTCAAAACACCGTCTTAA

Upstream 100 bases:

>100_bases
AAAAATGTTGATTAAGAGTGAATATAAGCCCCGGATGCTGCCCAAAGAAGAGCAGGTCAAAAAGCCGATGACCAGTAACG
GACGGATCAGCTTCGTCCTG

Downstream 100 bases:

>100_bases
TCCGAGTATCAACGAGATTGTTTTATGTTCAGCAAGTTAACCCCTTTGGCTGAAACCGGCATCCCGACCCTGTCGTGTGC
AAACGCGGCAGGGCGTTTGT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MAIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLE
RLSELVDVPIDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGL
ELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDART
GEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPS
LDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLA
RAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADN
KHIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS

Sequences:

>Translated_549_residues
MAIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLE
RLSELVDVPIDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGL
ELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDART
GEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPS
LDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLA
RAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADN
KHIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS
>Mature_548_residues
AIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLER
LSELVDVPIDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLE
LSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDARTG
EILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSL
DVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLAR
AYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADNK
HIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=540, Percent_Identity=39.8148148148148, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786854, Length=605, Percent_Identity=24.4628099173554, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 59857; Mature: 59726

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPT
CHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCC
ESLFAVPKEMKEMPSAAQLERLSELVDVPIDVLRNKLEQKGKSFIWIKRQLDPKVAEEVK
HHHHHCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
ALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLHGEDGAEVVLRD
HHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEC
RQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDART
CCCCCHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERL
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHC
NTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRM
CCCCEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEE
HSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPVSFEKQ
ECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCH
AVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADN
HCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
KHIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPL
CEEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCC
TAAAVKTPS
EECCCCCCC
>Mature Secondary Structure 
AIAVLFAGLIARGLYLQTVTYNFLKEQGDNRIVRTQTLPATRGTVSDRNGAVLALSAPT
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCC
ESLFAVPKEMKEMPSAAQLERLSELVDVPIDVLRNKLEQKGKSFIWIKRQLDPKVAEEVK
HHHHHCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
ALGLENFVFEKELKRHYPMGNLFAHVIGFTDIDGKGQEGLELSLEDSLHGEDGAEVVLRD
HHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEC
RQGNIVDSLDSPRNKAPKNGKDIILSLDQRIQTLAYEELNKAVEYHQAKAGTVVVLDART
CCCCCHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GEILALANTPAYDPNRPGRADSEQRRNRAVTDMIEPGSAIKPFVIAKALDAGKTDLNERL
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHC
NTQPYKIGPSPVRDTHVYPSLDVRGIMQKSSNVGTSKLSARFGAEEMYDFYHELGIGVRM
CCCCEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCEEE
HSGFPGETAGLLRNWRRWRPIEQATMSFGYGLQLSLLQLARAYTALTHDGVLLPVSFEKQ
ECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCH
AVAPQGKRIFKESTAREVRNLMVSVTEPGGTGTAGAVDGFDVGAKTGTARKFVNGRYADN
HCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
KHIATFIGFAPAKNPRVIVAVTIDEPTAHGYYGGVVAGPPFKKIMGGSLNILGISPTKPL
CEEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCC
TAAAVKTPS
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]