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The map label for this gene is ppx [H]

Identifier: 161870336

GI number: 161870336

Start: 1399521

End: 1401029

Strand: Direct

Name: ppx [H]

Synonym: NMCC_1380

Alternate gene names: 161870336

Gene position: 1399521-1401029 (Clockwise)

Preceding gene: 161870335

Following gene: 161870340

Centisome position: 64.99

GC content: 55.2

Gene sequence:

>1509_bases
ATGACCACCACCCCCGCAAACATCCTCGCCTCCGTCGATTTGGGTTCCAACAGTTTCCGCCTCCAGATTTGCGAAAACAA
CAACGGACAATTAAAAGTCATCGATTCGTTCAAACAGATGGTGCGCTTCGCCGCCGGTCTGGACGAACAGAAAAACCTGA
GTGCCGCTTCCCAAGAACAGGCTTTGGACTGTCTGGCAAAATTCGGCGAACGCCTGCGCGGCTTCCGCCCTGAACAGGTA
CGCGCCGTGGCAACCAATACATTCCGCGTCGCCAAAAACATCGCAGATTTCCTTCCCAAGGCCGAAGCGGCACTGGGTTT
CCCCATAGAAATCATCGCCGGGCGCGAAGAGGCGCGGCTGATTTATACCGGCGTGATCCACACCCTCCCCCCGGTCGGCG
GCAAAATGCTGGTTATCGACATCGGCGGCGGTTCGACAGAATTTGTCATCGGTTCGACGCTGAATCCCGACATTACCGAA
AGCCTGCCCTTGGGCTGCGTAACCTACAGCCTGCGCTTCTTCCAAAACAAAATCACCGCCAAAGACTTCCAATCTGCCAT
TTCCGCCGCCCGCAACGAAATCCAGCGCATCAGCAAAAATATGAGGCGCGAAGGTTGGGATTCCGCCGTCGGCACATCGG
GTTCGGCAAAATCCATCCGCGACGTGCTTGCCGCCGAAATGCCCCAAGAGGCGGACATTACCTACAAAGGCATGCGCGCC
CTCGCCGAACGCATCATCGAAGCCGGTTCGGTCAAAAAAGCCAAATTTGAAAACCTGAAACCGGAACGCATCGAAGTTTT
TGCCGGCGGACTTGCCGTGATGATGGCGGCGTTTGAGGAAATGAAACTCGACAGGATGACCGTAACCGAAGCCGCCCTGC
GCGACGGCGTGTTTTACGATTTGATCGGGCGCGGTTTAAACGAAGATATGCGCGGACAAACGGTTGCCGAGTTCCAACAC
CGCTACCACGTCAGCCTCAATCAGGCGAAACGCACCGCCGAGACCGCGCAAACCTTTATGGACAGCCTCTGCCACGCTAA
AAATGTTACGGTTCAAGAGCTTGCCTTGTGGCAACAGTATCTCGGACGCGCCGCCGCGTTGCACGAAATCGGTTTGGACA
TCGCCCACACCGGCTATCACAAGCATTCCGCCTACATCCTCGAAAACGCCGATATGCCGGGCTTTTCACGCAAGGAACAA
ACCATACTTGCCCAACTGGTCATCGGTCATCGCGGCGATATGAAAAAAATGAGCGGCATCATCGGCACCAACGAAATGTT
GTGGTATGCCGTTTTGTCCCTGCGCCTTGCCGCACTGTTCTGCCGTTCGCGCCAAGACCTGTCTTTCCCGAAAAACATGC
AGTTGCGCACGGATACGGAAAGCTGCGGCTTCATCCTGCGTATTGACAGGGAATGGCTGGAACGCCATCCCCTGATTGCC
GACGCATTGGAATATGAAAGCGTCCAATGGCAAAAAATCAATATGCCGTTTAAAGTCGAGGCCGTCTGA

Upstream 100 bases:

>100_bases
CGGCAACATCCGCGAGCAGAATCAAAAACAGCCGCATCATTTATTGTCAACGCCTGCGCCGTCAGAGTAACATTGCGTTT
TTCCCCCACCGATATCCGCC

Downstream 100 bases:

>100_bases
ACCTTGCGGGGCAAATGCCGTCCAAACCCTGTCCAGACGGCATTTGCCTGTCCGCAACATCCCGATATGCGCGGCACATC
TGCTCGGAACGGTCATGCAG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTTTPANILASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQALDCLAKFGERLRGFRPEQV
RAVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARLIYTGVIHTLPPVGGKMLVIDIGGGSTEFVIGSTLNPDITE
SLPLGCVTYSLRFFQNKITAKDFQSAISAARNEIQRISKNMRREGWDSAVGTSGSAKSIRDVLAAEMPQEADITYKGMRA
LAERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYDLIGRGLNEDMRGQTVAEFQH
RYHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQYLGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQ
TILAQLVIGHRGDMKKMSGIIGTNEMLWYAVLSLRLAALFCRSRQDLSFPKNMQLRTDTESCGFILRIDREWLERHPLIA
DALEYESVQWQKINMPFKVEAV

Sequences:

>Translated_502_residues
MTTTPANILASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQALDCLAKFGERLRGFRPEQV
RAVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARLIYTGVIHTLPPVGGKMLVIDIGGGSTEFVIGSTLNPDITE
SLPLGCVTYSLRFFQNKITAKDFQSAISAARNEIQRISKNMRREGWDSAVGTSGSAKSIRDVLAAEMPQEADITYKGMRA
LAERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYDLIGRGLNEDMRGQTVAEFQH
RYHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQYLGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQ
TILAQLVIGHRGDMKKMSGIIGTNEMLWYAVLSLRLAALFCRSRQDLSFPKNMQLRTDTESCGFILRIDREWLERHPLIA
DALEYESVQWQKINMPFKVEAV
>Mature_501_residues
TTTPANILASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQALDCLAKFGERLRGFRPEQVR
AVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARLIYTGVIHTLPPVGGKMLVIDIGGGSTEFVIGSTLNPDITES
LPLGCVTYSLRFFQNKITAKDFQSAISAARNEIQRISKNMRREGWDSAVGTSGSAKSIRDVLAAEMPQEADITYKGMRAL
AERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYDLIGRGLNEDMRGQTVAEFQHR
YHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQYLGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQT
ILAQLVIGHRGDMKKMSGIIGTNEMLWYAVLSLRLAALFCRSRQDLSFPKNMQLRTDTESCGFILRIDREWLERHPLIAD
ALEYESVQWQKINMPFKVEAV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=498, Percent_Identity=35.7429718875502, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI48994966, Length=504, Percent_Identity=34.1269841269841, Blast_Score=292, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55918; Mature: 55787

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTPANILASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQ
CCCCCCHHEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCHHCCCHHHHHH
ALDCLAKFGERLRGFRPEQVRAVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCEE
IYTGVIHTLPPVGGKMLVIDIGGGSTEFVIGSTLNPDITESLPLGCVTYSLRFFQNKITA
EEEEHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHCCH
KDFQSAISAARNEIQRISKNMRREGWDSAVGTSGSAKSIRDVLAAEMPQEADITYKGMRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LAERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYD
HHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LIGRGLNEDMRGQTVAEFQHRYHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQY
HHCCCCCCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQTILAQLVIGHRGDMKKMSGI
HHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCC
IGTNEMLWYAVLSLRLAALFCRSRQDLSFPKNMQLRTDTESCGFILRIDREWLERHPLIA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECHHHHHCCCCHH
DALEYESVQWQKINMPFKVEAV
HHHHHCCCCEEEECCCEEEEEC
>Mature Secondary Structure 
TTTPANILASVDLGSNSFRLQICENNNGQLKVIDSFKQMVRFAAGLDEQKNLSAASQEQ
CCCCCHHEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCHHCCCHHHHHH
ALDCLAKFGERLRGFRPEQVRAVATNTFRVAKNIADFLPKAEAALGFPIEIIAGREEARL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCEE
IYTGVIHTLPPVGGKMLVIDIGGGSTEFVIGSTLNPDITESLPLGCVTYSLRFFQNKITA
EEEEHHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHCCCCHHHHHHHHHHHHHCCH
KDFQSAISAARNEIQRISKNMRREGWDSAVGTSGSAKSIRDVLAAEMPQEADITYKGMRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
LAERIIEAGSVKKAKFENLKPERIEVFAGGLAVMMAAFEEMKLDRMTVTEAALRDGVFYD
HHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LIGRGLNEDMRGQTVAEFQHRYHVSLNQAKRTAETAQTFMDSLCHAKNVTVQELALWQQY
HHCCCCCCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGRAAALHEIGLDIAHTGYHKHSAYILENADMPGFSRKEQTILAQLVIGHRGDMKKMSGI
HHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCC
IGTNEMLWYAVLSLRLAALFCRSRQDLSFPKNMQLRTDTESCGFILRIDREWLERHPLIA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECHHHHHCCCCHH
DALEYESVQWQKINMPFKVEAV
HHHHHCCCCEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]