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The map label for this gene is lldA [H]

Identifier: 161870249

GI number: 161870249

Start: 1293094

End: 1294266

Strand: Reverse

Name: lldA [H]

Synonym: NMCC_1290

Alternate gene names: 161870249

Gene position: 1294266-1293094 (Counterclockwise)

Preceding gene: 161870251

Following gene: 161870243

Centisome position: 60.1

GC content: 53.03

Gene sequence:

>1173_bases
ATGAAACGTGATTTGAGCAAAATGACCTGCATCGAAGACTTGCGCCGCGTTGCCAAGCGCAAAATGCCGCGTATGTTTTA
CGATTACATCGATTCGGGTTCGTGGACGGAAACGACTTATCGGGAAAATACTTCGGATTTCAAAGACATCCGTTTCCGAC
AAAAAGTGTTGGTCAATATGGAGGGGCGCAGCCTCGAAACCAAAATGATTGGGCAGGATGTGAAAATGCCGGTGGCGATT
GCCCCGACTGGTTTCACGGGTATGGCGCACGCAGACGGTGAAATCTTGGCGGCGCGGGCGGCGGAGAAGTTCGGCATTCC
GTTTACGTTGTCCACCATGTCCATCTGCTCGATTGAAGACGTTGCCGAGAACACTTCCGCACCATTTTGGTTTCAGCTTT
ATGTGATGCGCGACCGCGAGTTTATGGAAAACCTGATTAAGCGCGCGAAGGATGCCAAATGTTCGGCATTGGTATTGACC
GCCGATTTGCAGGTTTTGGGTCAACGCCACAAAGACATCAAAAACGGCCTGTCCGCGCCGCCGAAACCGACCATCGCCAA
TTTAATCAATCTGGCGACCAAACCGGAATGGTGCATGAAAATGCTGAACACGGAACGCCGCACGTTCCGCAATATCGTCG
GACACGCGAAGAACGTCGGCGATTTGTCTTCGCTGTCTTCATGGACTTCCGAACAATTCGACCCGCGCCTGAGCTGGGAC
GATGTGGCGCGCATTAAAGATTTGTGGGGCGGCAAGCTGATTATCAAAGGCATTATGGAACCCGAAGACGCGGAAAAAGC
AGCGAAAAGCGGCGCGGACGCATTGGTCGTTTCCAACCACGGCGGCCGACAGCTCGACGATACCGTGTCTGCCATCAAAG
CCTTGCCCGACATCGTCAGCGCAGTGGGCAGCGACATCGAAGTTTGGATGGACAGCGGCATCCGCAGCGGTCAGGATATT
TTGAAGGCGTGGGCTTTGGGCGCGAAAGGTACAATGATAGGTCGGGCGTTTCTGTATGGCTTGGGCGCGTATGGAGAAGA
AGGCGTAACCCGCGCGCTGGAAATCCTATATAAGGAAATGGATATATCTATGGCGTTTACGGGGCACCGCGATATTCAAG
ATGTCGATGCCTCGATTTTAAGGGGTAAAGATTGGGGCAGGGAAACGGTTTAG

Upstream 100 bases:

>100_bases
ATCTTAGTGATTTATTTGGGTATTGCCTGAAATGCTGTCTGAAGGCTCAAGCGGTTTCGGACGGCATATTCCATCAGGCT
GTCAAACAGGGAAAAACAAG

Downstream 100 bases:

>100_bases
ATACTGAAAAATACGATGCCGTCTGAACACAGGGTTCGGACGGCATTAAAATTTGGCTGTATTTTAATAATGAACTATCT
GACAAAACGCCCTTTTGTAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKRDLSKMTCIEDLRRVAKRKMPRMFYDYIDSGSWTETTYRENTSDFKDIRFRQKVLVNMEGRSLETKMIGQDVKMPVAI
APTGFTGMAHADGEILAARAAEKFGIPFTLSTMSICSIEDVAENTSAPFWFQLYVMRDREFMENLIKRAKDAKCSALVLT
ADLQVLGQRHKDIKNGLSAPPKPTIANLINLATKPEWCMKMLNTERRTFRNIVGHAKNVGDLSSLSSWTSEQFDPRLSWD
DVARIKDLWGGKLIIKGIMEPEDAEKAAKSGADALVVSNHGGRQLDDTVSAIKALPDIVSAVGSDIEVWMDSGIRSGQDI
LKAWALGAKGTMIGRAFLYGLGAYGEEGVTRALEILYKEMDISMAFTGHRDIQDVDASILRGKDWGRETV

Sequences:

>Translated_390_residues
MKRDLSKMTCIEDLRRVAKRKMPRMFYDYIDSGSWTETTYRENTSDFKDIRFRQKVLVNMEGRSLETKMIGQDVKMPVAI
APTGFTGMAHADGEILAARAAEKFGIPFTLSTMSICSIEDVAENTSAPFWFQLYVMRDREFMENLIKRAKDAKCSALVLT
ADLQVLGQRHKDIKNGLSAPPKPTIANLINLATKPEWCMKMLNTERRTFRNIVGHAKNVGDLSSLSSWTSEQFDPRLSWD
DVARIKDLWGGKLIIKGIMEPEDAEKAAKSGADALVVSNHGGRQLDDTVSAIKALPDIVSAVGSDIEVWMDSGIRSGQDI
LKAWALGAKGTMIGRAFLYGLGAYGEEGVTRALEILYKEMDISMAFTGHRDIQDVDASILRGKDWGRETV
>Mature_390_residues
MKRDLSKMTCIEDLRRVAKRKMPRMFYDYIDSGSWTETTYRENTSDFKDIRFRQKVLVNMEGRSLETKMIGQDVKMPVAI
APTGFTGMAHADGEILAARAAEKFGIPFTLSTMSICSIEDVAENTSAPFWFQLYVMRDREFMENLIKRAKDAKCSALVLT
ADLQVLGQRHKDIKNGLSAPPKPTIANLINLATKPEWCMKMLNTERRTFRNIVGHAKNVGDLSSLSSWTSEQFDPRLSWD
DVARIKDLWGGKLIIKGIMEPEDAEKAAKSGADALVVSNHGGRQLDDTVSAIKALPDIVSAVGSDIEVWMDSGIRSGQDI
LKAWALGAKGTMIGRAFLYGLGAYGEEGVTRALEILYKEMDISMAFTGHRDIQDVDASILRGKDWGRETV

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=378, Percent_Identity=35.7142857142857, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI54234014, Length=377, Percent_Identity=34.4827586206897, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI7705393, Length=377, Percent_Identity=34.4827586206897, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1790033, Length=369, Percent_Identity=43.360433604336, Blast_Score=333, Evalue=8e-93,
Organism=Caenorhabditis elegans, GI193208036, Length=374, Percent_Identity=36.6310160427808, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI32566217, Length=289, Percent_Identity=34.2560553633218, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=389, Percent_Identity=32.3907455012853, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=35.978835978836, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=35.978835978836, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=35.978835978836, Blast_Score=241, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 43487; Mature: 43487

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDLSKMTCIEDLRRVAKRKMPRMFYDYIDSGSWTETTYRENTSDFKDIRFRQKVLVNM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEC
EGRSLETKMIGQDVKMPVAIAPTGFTGMAHADGEILAARAAEKFGIPFTLSTMSICSIED
CCCCCHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
VAENTSAPFWFQLYVMRDREFMENLIKRAKDAKCSALVLTADLQVLGQRHKDIKNGLSAP
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCC
PKPTIANLINLATKPEWCMKMLNTERRTFRNIVGHAKNVGDLSSLSSWTSEQFDPRLSWD
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
DVARIKDLWGGKLIIKGIMEPEDAEKAAKSGADALVVSNHGGRQLDDTVSAIKALPDIVS
HHHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AVGSDIEVWMDSGIRSGQDILKAWALGAKGTMIGRAFLYGLGAYGEEGVTRALEILYKEM
HHCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DISMAFTGHRDIQDVDASILRGKDWGRETV
CCEEEECCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKRDLSKMTCIEDLRRVAKRKMPRMFYDYIDSGSWTETTYRENTSDFKDIRFRQKVLVNM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEC
EGRSLETKMIGQDVKMPVAIAPTGFTGMAHADGEILAARAAEKFGIPFTLSTMSICSIED
CCCCCHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
VAENTSAPFWFQLYVMRDREFMENLIKRAKDAKCSALVLTADLQVLGQRHKDIKNGLSAP
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCC
PKPTIANLINLATKPEWCMKMLNTERRTFRNIVGHAKNVGDLSSLSSWTSEQFDPRLSWD
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHH
DVARIKDLWGGKLIIKGIMEPEDAEKAAKSGADALVVSNHGGRQLDDTVSAIKALPDIVS
HHHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AVGSDIEVWMDSGIRSGQDILKAWALGAKGTMIGRAFLYGLGAYGEEGVTRALEILYKEM
HHCCCHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DISMAFTGHRDIQDVDASILRGKDWGRETV
CCEEEECCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA