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The map label for this gene is aceE [H]

Identifier: 161870214

GI number: 161870214

Start: 1247705

End: 1250368

Strand: Direct

Name: aceE [H]

Synonym: NMCC_1254

Alternate gene names: 161870214

Gene position: 1247705-1250368 (Clockwise)

Preceding gene: 161870213

Following gene: 161870215

Centisome position: 57.94

GC content: 54.43

Gene sequence:

>2664_bases
ATGTCCACCCAATTACACGATGTTGACCCTATCGAAACCCAAGAGTGGCTGGACGCGTTAAGCTCCGTCCTCGAATATGA
AGGCGGCGAACGCGCGCAATACCTCTTGGAAAACCTGGTCAAATACTGCCGCGACAAGGGCGTACGTATGCCACACGGCA
CGACCACACCGTATTTGAATACCGTTTCGGTTGAAAACGAAAAAGGCATTCCGGGCGACCAAAACATCGAACACCGCATC
CGCGCATTCGTGCGCTGGAACGCCGCCGCCATCGTATTGCGCGCCGGCAAGAAAGATTTGGAACTGGGTGGGCACATCGC
ATCTTTCCAATCTGCCGCCACCATGTACGAAGTCGGTTTCAACCACTTTTGGAAAGCCAAAGGCGAAGGCGAAGAAGGCG
ATTTGGTCTTCTTCCAAGGTCACGTCGCCCCGGGCATCTATGCACGCGCATTCGTCGAGGGCCGTCTGACCGAAGACCAG
CTGAACAACTTCCGCCAAGAAGTGGACGGACACGGTCTGCCTTCCTATCCGCACCCCCACCTCTTGCCCGACTTTTGGCA
GTTCCCGACCGTATCCATGGGCTTGGGGCCCATCATGGCGATTTATCAGGCGCGTTTCCTGAAATACTTGGAATCGCGTG
GTTTGGCAAAAACCAAAGGCCGTAAAGTATGGTGTTTCTGCGGCGACGGCGAAATGGACGAACCCGAATCTCAAGGTGCA
ATCGCACTGGCTGCACGCGAAGGCTTGGACAACCTGATTTTCGTCATCAACTGCAATCTGCAACGCTTGGACGGTCCGGT
ACGCGGCAACGGCAAAATCATCCAAGAATTGGAAGGCAACTTTGCCGGCGCCGGCTGGAATGTCGTCAAAGTCATTTGGG
GCCGCCGCTGGGACCGCCTCTTGGCGAAAGACAAAGACGGTATCCTGCGCCAACGTATGGAAGAATGTTTGGACGGCGAC
TACCAAACTTACAAATCCAAAGACGGCGCGTATGTGCGCGAACACTTCTTCAATACGCCCGAACTGAAAACATTGGTTGC
CGATATGACCGATGAGCAACTCTGGGCATTGAACCGCGGCGGCCACGACCCGCAAAAAGTGTACAACGCCTACGACCGCG
CAGCGAACCATGCCGACGGCAAACCTACCGTCATCTTGGCGAAAACCATTAAAGGTTACGGTATGGGCGCATCCGGCGAA
GGTCAGAACGTTGCCCACCAAGCCAAAAAAATGGACAAAGCGTCCCTGAAACAATTCCGCGACCGCTTTGACATTCCGGT
TACCGACGAACAAATCGAAAGCGGCGATCTGCCTTACCTGACTTTTGCCCCCGATACGGAAGAATACAAATACCTGCACG
CACGCCGCGATGCTTTGGGTGGCTACCTGCCGCAACGCAAACCGACGCAGGAAGTATTGGAAGTGCCCGAGCTGTCAGCA
TTCGACGCACAACTCAAATCCAGCGGTGAACGCGAGTTCTCGACCACGATGGCATTCGTCCGCATCCTGTCCACTTTGCT
GAAAGACAAAAAAATCGGCAAACGCGTCGTACCTATCGTTCCCGACGAAAGCCGTACTTTCGGCATGGAAGGTATGTTCC
GCCAATACGGTATTTGGAATCCGAAAGGTCAGCAATATACCCCTCAAGACAAAGACCAACTGATGTTCTATAAAGAATCC
GTTGACGGTCAAATCTTGCAAGAAGGTATTAACGAACCGGGCGCGATGGCCGACTGGATTGCGGCTGCAACCAGCTACGC
CAACAGCAACTTCGCGATGATTCCGTTCTACATTTACTATTCTATGTTCGGTTTCCAACGTGTCGGCGACTTGGCATGGG
CAGCCGGTGATATGCACGCGCGCGGCTTCCTGCTGGGCGGTACTGCCGGCCGTACGACGCTGAACGGCGAAGGCCTGCAA
CACGAAGACGGCCACAGCCACATCCAGGCCGACCTGATTCCGAACTGCGTATCTTATGACCCGACTTTCCAATACGAAGT
CGCCGTCATCGTACAAGACGGTCTGCGCCGTATGTATGCCAATAATGAAGACGTGTTCTACTACATCACCCTGATGAACG
AGAACTACACCCATCCGGATATGCCCGAAGGTGCGGAACAAGACATCCTGAAAGGTATGTATCTGCTGAAAGCCGGCGGC
AAAGGCGACAAGAAAGTTCAATTGATGGGCTCCGGTACCATCCTGCAAGAAGTCATTGCCGGTGCCGAGCTGCTGAAAGC
CGACTTCGGCGTAGAAGCAGACATCTGGTCTTGCCCGTCCTTCAACCTGCTGCACCGCGACGCTGTCGAGGTAGAACGCT
TCAACCGCCTGCATCCGCTGGAAGCCGAAAAAGTACCTTTCGTTACTTCCAAATTGCAAGGTCATGACGGTCCGGTTATT
GCCGCTACCGACTATATCCGCAGCTATGCTGACCGTATCCGCGCCTACATCCCGAACGACTACCACGTCTTGGGTACTGA
CGGCTTCGGCCGCTCCGACAGCCGCGCCAACCTGCGCCGCTTCTTTGAAGTGGATCGCTACAACGTTGCCGTGGCAGCAT
TGAGCGCATTGGCGGAACAAGGCAAAGTCAGCAAAGAAACCGTTCAACAAGCCATTGAGAAATACGGCATCAAAGCCGAT
TCAGCTCCTAGCTGGAAACGCTGA

Upstream 100 bases:

>100_bases
AGAAATTTTCGTTTTTGCTTATTATTTTTCACAAACGAAAATAAAGGGGTTGGCTACACCCTCCCTGCCGATTAAACACT
CAACATAAAGGATAGATACT

Downstream 100 bases:

>100_bases
TTGATGTTTCAGACGGTCTGTTTGCCCCATTCCGACATCAGGCCGTCTGAAAACCGAATGCCCGAATGGTTTGAGCAGAC
AAACCGTACCGATGCCGCCT

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSTQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLNTVSVENEKGIPGDQNIEHRI
RAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGFNHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQ
LNNFRQEVDGHGLPSYPHPHLLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA
IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRLLAKDKDGILRQRMEECLDGD
YQTYKSKDGAYVREHFFNTPELKTLVADMTDEQLWALNRGGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGE
GQNVAHQAKKMDKASLKQFRDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQEVLEVPELSA
FDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYGIWNPKGQQYTPQDKDQLMFYKES
VDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFYIYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQ
HEDGHSHIQADLIPNCVSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLKAGG
KGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNRLHPLEAEKVPFVTSKLQGHDGPVI
AATDYIRSYADRIRAYIPNDYHVLGTDGFGRSDSRANLRRFFEVDRYNVAVAALSALAEQGKVSKETVQQAIEKYGIKAD
SAPSWKR

Sequences:

>Translated_887_residues
MSTQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLNTVSVENEKGIPGDQNIEHRI
RAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGFNHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQ
LNNFRQEVDGHGLPSYPHPHLLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA
IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRLLAKDKDGILRQRMEECLDGD
YQTYKSKDGAYVREHFFNTPELKTLVADMTDEQLWALNRGGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGE
GQNVAHQAKKMDKASLKQFRDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQEVLEVPELSA
FDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYGIWNPKGQQYTPQDKDQLMFYKES
VDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFYIYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQ
HEDGHSHIQADLIPNCVSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLKAGG
KGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNRLHPLEAEKVPFVTSKLQGHDGPVI
AATDYIRSYADRIRAYIPNDYHVLGTDGFGRSDSRANLRRFFEVDRYNVAVAALSALAEQGKVSKETVQQAIEKYGIKAD
SAPSWKR
>Mature_886_residues
STQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLNTVSVENEKGIPGDQNIEHRIR
AFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGFNHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQL
NNFRQEVDGHGLPSYPHPHLLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGAI
ALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRLLAKDKDGILRQRMEECLDGDY
QTYKSKDGAYVREHFFNTPELKTLVADMTDEQLWALNRGGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEG
QNVAHQAKKMDKASLKQFRDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQEVLEVPELSAF
DAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYGIWNPKGQQYTPQDKDQLMFYKESV
DGQILQEGINEPGAMADWIAAATSYANSNFAMIPFYIYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQH
EDGHSHIQADLIPNCVSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLKAGGK
GDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNRLHPLEAEKVPFVTSKLQGHDGPVIA
ATDYIRSYADRIRAYIPNDYHVLGTDGFGRSDSRANLRRFFEVDRYNVAVAALSALAEQGKVSKETVQQAIEKYGIKADS
APSWKR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=62.2448979591837, Blast_Score=1129, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99596; Mature: 99464

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLN
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TVSVENEKGIPGDQNIEHRIRAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGF
EEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHCH
NHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQLNNFRQEVDGHGLPSYPHPH
HHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA
CCCHHHCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCC
IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRL
EEEEECCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCHHHHH
LAKDKDGILRQRMEECLDGDYQTYKSKDGAYVREHFFNTPELKTLVADMTDEQLWALNRG
HHCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCHHHHHHHCCC
GHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQFR
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQEVLEVPELSA
HHCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHH
FDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYGIWN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCC
PKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFYIYY
CCCCCCCCCCHHHEEEEHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHH
SMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNCVSYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCEEEHHHCCCCCCCC
PTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLKAGG
CCCEEEEEEEEHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHEEECCC
KGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNRLHPL
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
EAEKVPFVTSKLQGHDGPVIAATDYIRSYADRIRAYIPNDYHVLGTDGFGRSDSRANLRR
CCCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
FFEVDRYNVAVAALSALAEQGKVSKETVQQAIEKYGIKADSAPSWKR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
STQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TVSVENEKGIPGDQNIEHRIRAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGF
EEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHCH
NHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQLNNFRQEVDGHGLPSYPHPH
HHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA
CCCHHHCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCC
IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRL
EEEEECCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHCCHHHHH
LAKDKDGILRQRMEECLDGDYQTYKSKDGAYVREHFFNTPELKTLVADMTDEQLWALNRG
HHCCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCHHHHHHHCCC
GHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQFR
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQEVLEVPELSA
HHCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHH
FDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYGIWN
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCC
PKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFYIYY
CCCCCCCCCCHHHEEEEHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHH
SMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNCVSYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCEEEHHHCCCCCCCC
PTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLKAGG
CCCEEEEEEEEHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHEEECCC
KGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNRLHPL
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
EAEKVPFVTSKLQGHDGPVIAATDYIRSYADRIRAYIPNDYHVLGTDGFGRSDSRANLRR
CCCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
FFEVDRYNVAVAALSALAEQGKVSKETVQQAIEKYGIKADSAPSWKR
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]