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The map label for this gene is ung [H]

Identifier: 161870064

GI number: 161870064

Start: 1087308

End: 1087967

Strand: Direct

Name: ung [H]

Synonym: NMCC_1101

Alternate gene names: 161870064

Gene position: 1087308-1087967 (Clockwise)

Preceding gene: 161870063

Following gene: 161870066

Centisome position: 50.49

GC content: 54.24

Gene sequence:

>660_bases
ATGGACACTTGGCACGATGCACTCGGCGGCGAAAAACAGCAGCCGTATTTTCAGGAAATTTTAAATGCAGTCAGGCAGGA
ACGTTTGTCGGGACAAATCATCTATCCGCCGGCGGCGGATGTGTTCAACGCATTCCGCCTGACAGCGTTCGACCGGGTCA
AAGCCGTCATTCTCGGACAAGATCCGTATCACGGGGCAGGGCAGGCGCACGGTTTGGCATTTTCCGTCCGGCAGGGTATC
CGCATACCGCCGTCTTTACTCAATATCTACAAGGAGTTGGAAACCGACATCGAAGGCTTTTCCATTCCCGCGCACGGCTG
TCTGACAGCGTGGGCGGAGCAGGGCGTATTGCTTCTGAACACGGTTTTGACGGTGCGTGCAGGACAGGCGCATTCGCACG
CCCTTTTAGGCTGGGAACGCTTTACCGATACCGTCATCAGGCAGCTTGCGGCGCACCGCAAGCACCTTGTCTTCATGTTG
TGGGGTGGGTATGCGCAACAAAAAAGGAAACTGATAGACAGTCAAAATCATTTGATACTGACCGCACCGCATCCGTCTCC
TCTGTCGGCATATCGCGGTTTTTTCGGTTGCCGCCATTTTTCACAGGCAAACAGCTATTTGAGCCGGCACGGTATCGATC
CGATAAACTGGAAGCTGTGA

Upstream 100 bases:

>100_bases
GCAACAAACCATACAGTCATACATTTCCCCACAAAGCGCGTCGTTTGACAAAATAACGCAATATCAGCAGTATAGCCGAA
TTTGAAAGGATAGGGCAGAT

Downstream 100 bases:

>100_bases
ATGCCGATATAGCCGTTGCCGCCGGCGTGTTAAAATCGCGTTTGATTTGTAATTTCCATTTATTAGGCAAAACCTTATGG
CAATCAAAAAAAAATCAGCT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPAADVFNAFRLTAFDRVKAVILGQDPYHGAGQAHGLAFSVRQGI
RIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGVLLLNTVLTVRAGQAHSHALLGWERFTDTVIRQLAAHRKHLVFML
WGGYAQQKRKLIDSQNHLILTAPHPSPLSAYRGFFGCRHFSQANSYLSRHGIDPINWKL

Sequences:

>Translated_219_residues
MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPAADVFNAFRLTAFDRVKAVILGQDPYHGAGQAHGLAFSVRQGI
RIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGVLLLNTVLTVRAGQAHSHALLGWERFTDTVIRQLAAHRKHLVFML
WGGYAQQKRKLIDSQNHLILTAPHPSPLSAYRGFFGCRHFSQANSYLSRHGIDPINWKL
>Mature_219_residues
MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPAADVFNAFRLTAFDRVKAVILGQDPYHGAGQAHGLAFSVRQGI
RIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGVLLLNTVLTVRAGQAHSHALLGWERFTDTVIRQLAAHRKHLVFML
WGGYAQQKRKLIDSQNHLILTAPHPSPLSAYRGFFGCRHFSQANSYLSRHGIDPINWKL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=54.8387096774194, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=54.8387096774194, Blast_Score=240, Evalue=6e-64,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=67.4418604651163, Blast_Score=300, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=49.3087557603687, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=45.1476793248945, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24629; Mature: 24629

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPAADVFNAFRLTAFDRVKAVILGQ
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHEEEEECC
DPYHGAGQAHGLAFSVRQGIRIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGVLLLN
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHH
TVLTVRAGQAHSHALLGWERFTDTVIRQLAAHRKHLVFMLWGGYAQQKRKLIDSQNHLIL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCEEE
TAPHPSPLSAYRGFFGCRHFSQANSYLSRHGIDPINWKL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDTWHDALGGEKQQPYFQEILNAVRQERLSGQIIYPPAADVFNAFRLTAFDRVKAVILGQ
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHEEEEECC
DPYHGAGQAHGLAFSVRQGIRIPPSLLNIYKELETDIEGFSIPAHGCLTAWAEQGVLLLN
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHH
TVLTVRAGQAHSHALLGWERFTDTVIRQLAAHRKHLVFMLWGGYAQQKRKLIDSQNHLIL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCEEE
TAPHPSPLSAYRGFFGCRHFSQANSYLSRHGIDPINWKL
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA