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The map label for this gene is vacB [H]

Identifier: 161870046

GI number: 161870046

Start: 1063090

End: 1065489

Strand: Direct

Name: vacB [H]

Synonym: NMCC_1082

Alternate gene names: 161870046

Gene position: 1063090-1065489 (Clockwise)

Preceding gene: 161870045

Following gene: 161870047

Centisome position: 49.37

GC content: 52.62

Gene sequence:

>2400_bases
ATGTCAACAGTCCAAATGAATAAAAATATTAAATCTTTAAATTTACGGGAAAAAGACCCGTTTTTAAGTCGTGAAAAACA
GCGTTATGAACATCCTTTGCCCAGTCGGGAATGGATAATCGAATTGTTGGAGCGCAAAGGTGTGCCTTCAAAAATCGAAT
CGCTTGCGCGCGAACTGTCGATTACGGAAGACGAGTATGTCTTTTTTGAACGCCGTCTGAAGGCGATGGCGCGGGACGGT
CAGGTTTTAATCAACCGTCGGGGCGCGGTTTGCGCGGCGGACAAATTGGATTTGGTCAAATGCCGCGTCGAGGCGCATAA
GGACGGTTTCGGTTTTGCCGTGCCGCTCACGCCCGCCAAAGACGGTGATTTTGTTTTGTATGAACGCCAGATGCGCGGCA
TTATGCACGGCGATATTGTCACTGTTCGTCCTGCCGGCATGGACCGTAGGGGCCGCCGCGAAGGGACAGTTCTGGATATT
GTCGAACGCGCGCAAAGCAAAGTGGTCGGCCGTTTCTATATGGATAGGGGCGTGGCGATTTTGGAGCCGGAAGACAAGCG
TCTGAACCAAAGCATCGTATTGGAACCGGACGGCGTGGCGCGTTTCAAACCTGAATCCGGTCAGGTCATCGTCGGCGAAA
TTGAGGTTTATCCTGAGCAAAACCGGCCGGCAGTGGCAAAAATCATCGAAGTTTTGGGCGATTATGCCGACAGCGGCATG
GAGATTGAAATTGCCGTGCGCAAGCATCATTTGCCGCACCAATTCAGTGAAGCGTGTGCCAAAGCCGTGAAAAAAATTCC
CGACCATGTACGCAAAAGCGATTTGAAAGGCCGCGTCGATTTGCGCGACCTGCCTTTGGTAACGATTGACGGCGAAACGG
CTCGAGATTTTGACGATGCGGTGTTTGCCGAAAAAATCGGACGCAATTACCGTCTGGTCGTGGCGATTGCCGATGTCAGC
CATTATGTCCGCCCCGATGACGCTATCGACACGGACGCTCAGGAACGCAGCACCAGTGTTTACTTCCCGCGCCGCGTGAT
TCCCATGTTGCCGGAAAACCTGTCCAACGGCATCTGCTCGCTCAATCCTAATGTCGAGCGTTTGTGTATGGTGTGCGATA
TGGTTATCACTTACGCGGGCAATATTAAAGAATACCGCTTCTACCCCGCCGTGATGCGCTCTCATGCCCGCCTGACCTAC
AACCAAGTTTGGAAATGGCTTTCAGGCGGCATCGGGCATCCGTTCAAAGCCCAAATCGACACGCTTTACAAACTCTTCAA
AATCCTTCAGAAAAAGCGTTTCGAACGCGGGGCGGTGGAGTTTGACAGCATCGAAACCCAAATGCTTTTCGACGACAACG
GTAAAATTGAAAAAATCGTCCCCGTTGTCCGCAACGATGCCCACAAGCTGATTGAAGAATGTATGTTGGCGGCAAACGTT
TGCGCAGCGGATTTTCTGTTGAAAAACAAGCATACCGCATTGTTCCGCAACCATTTGGGGCCCACGCCCGAAAAACTCGC
CGCCTTGCGCGAGCAGTTCGGTCTGTTGGGGCTTCAACTTGGCGGCGGCGACAACCCGTCGCCGAAAGACTATGCCGCGC
TTGCCGGACAGTTCAAAGGCAGGCCGGATGCCGAATTGCTGCAAGTCATGATGTTGCGCTCCATGCAACAGGCGGTTTAC
GAACCGCATTGCGACGGACACTTTGGTCTTGCCTACGAAGCATACGCCCACTTCACCTCGCCCATCCGCCGCTATCCCGA
CCTGACCGTACACCGCGCCATCAAAGCCGTGTTGAATCAGCAAACCTACACGCCAAAAAAAAGCTGGCAGGCTTTGGGCG
TGCATACCTCGTTCTGTGAGCGCCGTGCCGACGACGCCAGCCGCGACGTGGAAAACTGGCTGAAAACCTACTATATGCGT
GACAAAGTCGGCGAAATATTTGAAGGCAAAATTTCCGGGGTGGCAAATTTTGGAATATTTGTCACTTTGGACGATATCCA
TATCGACGGTCTGGTGCATATCAGCGATTTGGGCGAAGACTATTTCAACTTCCGCCCCGAAATCATGGCAATCGAAGGTG
AACGCAGTGGCATCCGTTTCAATATGGGCGACAGGGTTGCCATTAAAGTGGCCCGTGCCGATTTGGATGATGGAAAAATC
GATTTTGTCCTGATTGCCGAGGGGAGCGGCAGAGGGCGGAAAGTTAAATCATCCGCGTCTGCCAAACCGGCAGGGACGGC
GGGGAAAGGGAAGCCGAAAACCGCCGCCGGGAAAAAAACAGCCCGAGGCGGCAAAGTAAGGGGAAGGGGCGCGTCTGCCG
CCGCAGAATCGGGGAAAAAGGCAAAGAAACCGATTCCGATTGAAGTACAAAAGGTAAAAAAACGGAAAGGCAAATCATAA

Upstream 100 bases:

>100_bases
CGCGTCTACCAATTCCGCCACCCGGGCTTTGCTTTATTTGCTGTTTTGCGGTACAGTGTCCTGCCGCAAAGAAGTCGCTA
TTATATAGTTCATAAAGAGA

Downstream 100 bases:

>100_bases
TGCTGACGGGGCGGCTTGGGGAGGGCAGGGCAGGGCATACTTTCCCGAAGCCGCCGCCCGATTTTTTGATATGGCGGCCG
GCGCATCATTTCAGGCCAAT

Product: ribonuclease

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MSTVQMNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELSITEDEYVFFERRLKAMARDG
QVLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAKDGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDI
VERAQSKVVGRFYMDRGVAILEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGM
EIEIAVRKHHLPHQFSEACAKAVKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEKIGRNYRLVVAIADVS
HYVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICSLNPNVERLCMVCDMVITYAGNIKEYRFYPAVMRSHARLTY
NQVWKWLSGGIGHPFKAQIDTLYKLFKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANV
CAADFLLKNKHTALFRNHLGPTPEKLAALREQFGLLGLQLGGGDNPSPKDYAALAGQFKGRPDAELLQVMMLRSMQQAVY
EPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMR
DKVGEIFEGKISGVANFGIFVTLDDIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAIKVARADLDDGKI
DFVLIAEGSGRGRKVKSSASAKPAGTAGKGKPKTAAGKKTARGGKVRGRGASAAAESGKKAKKPIPIEVQKVKKRKGKS

Sequences:

>Translated_799_residues
MSTVQMNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELSITEDEYVFFERRLKAMARDG
QVLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAKDGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDI
VERAQSKVVGRFYMDRGVAILEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGM
EIEIAVRKHHLPHQFSEACAKAVKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEKIGRNYRLVVAIADVS
HYVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICSLNPNVERLCMVCDMVITYAGNIKEYRFYPAVMRSHARLTY
NQVWKWLSGGIGHPFKAQIDTLYKLFKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANV
CAADFLLKNKHTALFRNHLGPTPEKLAALREQFGLLGLQLGGGDNPSPKDYAALAGQFKGRPDAELLQVMMLRSMQQAVY
EPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMR
DKVGEIFEGKISGVANFGIFVTLDDIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAIKVARADLDDGKI
DFVLIAEGSGRGRKVKSSASAKPAGTAGKGKPKTAAGKKTARGGKVRGRGASAAAESGKKAKKPIPIEVQKVKKRKGKS
>Mature_798_residues
STVQMNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELSITEDEYVFFERRLKAMARDGQ
VLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAKDGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDIV
ERAQSKVVGRFYMDRGVAILEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGME
IEIAVRKHHLPHQFSEACAKAVKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDAVFAEKIGRNYRLVVAIADVSH
YVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICSLNPNVERLCMVCDMVITYAGNIKEYRFYPAVMRSHARLTYN
QVWKWLSGGIGHPFKAQIDTLYKLFKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANVC
AADFLLKNKHTALFRNHLGPTPEKLAALREQFGLLGLQLGGGDNPSPKDYAALAGQFKGRPDAELLQVMMLRSMQQAVYE
PHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQQTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMRD
KVGEIFEGKISGVANFGIFVTLDDIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAIKVARADLDDGKID
FVLIAEGSGRGRKVKSSASAKPAGTAGKGKPKTAAGKKTARGGKVRGRGASAAAESGKKAKKPIPIEVQKVKKRKGKS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=566, Percent_Identity=29.1519434628975, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI190014623, Length=566, Percent_Identity=29.1519434628975, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI134288890, Length=503, Percent_Identity=26.8389662027833, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI19115966, Length=576, Percent_Identity=26.0416666666667, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI219521928, Length=576, Percent_Identity=26.0416666666667, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI156105695, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156105693, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI87082383, Length=729, Percent_Identity=47.599451303155, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=580, Percent_Identity=28.448275862069, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=491, Percent_Identity=30.9572301425662, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=422, Percent_Identity=30.3317535545024, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=506, Percent_Identity=28.6561264822134, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320499, Length=483, Percent_Identity=22.9813664596273, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24649634, Length=478, Percent_Identity=29.4979079497908, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24654592, Length=448, Percent_Identity=30.3571428571429, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI19922976, Length=448, Percent_Identity=30.3571428571429, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24654597, Length=448, Percent_Identity=30.3571428571429, Blast_Score=166, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89674; Mature: 89543

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVQMNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELS
CCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHC
ITEDEYVFFERRLKAMARDGQVLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAK
CCCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCHHEEEEEHHHCCCCCEEEEECCCCC
DGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDIVERAQSKVVGRFYMDRGVAI
CCCEEEEHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
LEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGM
ECCCHHHCCCEEEECCCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
EIEIAVRKHHLPHQFSEACAKAVKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDA
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHH
VFAEKIGRNYRLVVAIADVSHYVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICS
HHHHHHCCCEEEEEEEECCHHHCCCCCCCCCCHHHCCCCEECCHHHHHCCCHHHCCCEEE
LNPNVERLCMVCDMVITYAGNIKEYRFYPAVMRSHARLTYNQVWKWLSGGIGHPFKAQID
CCCCHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHH
TLYKLFKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHH
CAADFLLKNKHTALFRNHLGPTPEKLAALREQFGLLGLQLGGGDNPSPKDYAALAGQFKG
HHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHCCCC
RPDAELLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEIFEGKISGVANFGIF
CCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCEEECEEE
VTLDDIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAIKVARADLDDGKI
EEEECEEECCEEEHHHCCCHHHCCCCEEEEEECCCCCEEECCCCEEEEEEEECCCCCCCE
DFVLIAEGSGRGRKVKSSASAKPAGTAGKGKPKTAAGKKTARGGKVRGRGASAAAESGKK
EEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
AKKPIPIEVQKVKKRKGKS
CCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
STVQMNKNIKSLNLREKDPFLSREKQRYEHPLPSREWIIELLERKGVPSKIESLARELS
CCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHC
ITEDEYVFFERRLKAMARDGQVLINRRGAVCAADKLDLVKCRVEAHKDGFGFAVPLTPAK
CCCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCHHEEEEEHHHCCCCCEEEEECCCCC
DGDFVLYERQMRGIMHGDIVTVRPAGMDRRGRREGTVLDIVERAQSKVVGRFYMDRGVAI
CCCEEEEHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
LEPEDKRLNQSIVLEPDGVARFKPESGQVIVGEIEVYPEQNRPAVAKIIEVLGDYADSGM
ECCCHHHCCCEEEECCCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
EIEIAVRKHHLPHQFSEACAKAVKKIPDHVRKSDLKGRVDLRDLPLVTIDGETARDFDDA
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHH
VFAEKIGRNYRLVVAIADVSHYVRPDDAIDTDAQERSTSVYFPRRVIPMLPENLSNGICS
HHHHHHCCCEEEEEEEECCHHHCCCCCCCCCCHHHCCCCEECCHHHHHCCCHHHCCCEEE
LNPNVERLCMVCDMVITYAGNIKEYRFYPAVMRSHARLTYNQVWKWLSGGIGHPFKAQID
CCCCHHHHHHHHHHHHHHCCCCHHHEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHH
TLYKLFKILQKKRFERGAVEFDSIETQMLFDDNGKIEKIVPVVRNDAHKLIEECMLAANV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHHHHHH
CAADFLLKNKHTALFRNHLGPTPEKLAALREQFGLLGLQLGGGDNPSPKDYAALAGQFKG
HHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHCCCC
RPDAELLQVMMLRSMQQAVYEPHCDGHFGLAYEAYAHFTSPIRRYPDLTVHRAIKAVLNQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
QTYTPKKSWQALGVHTSFCERRADDASRDVENWLKTYYMRDKVGEIFEGKISGVANFGIF
CCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHCCEEECEEE
VTLDDIHIDGLVHISDLGEDYFNFRPEIMAIEGERSGIRFNMGDRVAIKVARADLDDGKI
EEEECEEECCEEEHHHCCCHHHCCCCEEEEEECCCCCEEECCCCEEEEEEEECCCCCCCE
DFVLIAEGSGRGRKVKSSASAKPAGTAGKGKPKTAAGKKTARGGKVRGRGASAAAESGKK
EEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
AKKPIPIEVQKVKKRKGKS
CCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]