Click here to switch to the map view.

The map label for this gene is typA [H]

Identifier: 161870045

GI number: 161870045

Start: 1060426

End: 1062114

Strand: Direct

Name: typA [H]

Synonym: NMCC_1078

Alternate gene names: 161870045

Gene position: 1060426-1062114 (Clockwise)

Preceding gene: 161870044

Following gene: 161870046

Centisome position: 49.24

GC content: 56.72

Gene sequence:

>1689_bases
ATGGACAGCAACGACCTCGAAAAAGAACGCGGCATCACCATCCTCGCCAAAAACACCGCCATCGATTACGAAGGCTACCA
CATCAATATCGTCGACACGCCGGGACACGCCGACTTCGGCGGCGAAGTAGAGCGCGTTTTGGGGATGGTGGACTGCGTCG
TCTTGTTGGTGGACGCGCAGGAAGGCCCGATGCCGCAAACCCGTTTCGTGACCAAAAAAGCCTTGGCTTTGGGGCTGAAA
CCGATTGTCGTCATCAATAAAATCGACAAACCGTCCGCCCGTCCGAGCTGGGTCATCGACCAAACTTTCGAGCTGTTCGA
CAACTTGGGCGCGACCGACGAGCAGTTGGATTTCCCGATTGTTTATGCTTCCGGTCTGTCCGGTTTCGCCAAATTGGAAG
AAACCGACGAGAGCAACGACATGCGTCCGCTGTTCGATACTATCTTAAAATATACGCCTGCACCGAGCGGCAGCGCGGAC
GAAACGCTGCAACTGCAAATTTCCCAACTCGACTACGACAACTACACCGGCCGCCTCGGCATCGGTCGTATCTTGAACGG
ACGCATCAAACCCGGCCAAACCGTTGCCGTCATGAACCACGAGCAGCAAATCGCCCAAGGCCGCATCAACCAGCTTTTGG
GTTTCAAAGGCTTGGAACGCGTACCGCTTGAAGAAGCCGAAGCCGGCGACATCGTGATTATTTCCGGTATCGAAGACATC
GGCATCGGCGTAACCATCACCGACAAAGACAACCCCAAAGGCCTGCCGATGTTGAGCGTGGACGAACCGACGCTGACGAT
GGACTTTATGGTCAACACCAGCCCGCTGGCGGGTACGGAAGGCAAATTCGTAACCAGCCGCCAAATCCGCGACCGCCTGC
AAAAAGAATTGCTGACCAACGTCGCCCTGCGCGTGGAAGACACCGCCGATGCCGACGTGTTCCGCGTATCCGGACGCGGC
GAGCTGCACCTGACCATTTTGTTGGAAAATATGCGCCGCGAAGGCTACGAACTCGCCGTCGGCAAACCGCGCGTCGTGTA
CCGCGACATCGACGGTCAAAAATGCGAACCTTATGAAAACCTGACCGTGGACGTACCCGACGACAACCAAGGCGCGGTAA
TGGAAGAACTCGGCCGCCGCCGTGGCGAACTGACTAATATGGAAAGCGACGGCAACGGACGCACCCGCCTCGAATACCAT
ATTCCAGCGCGCGGCTTGATCGGTTTCCAAGGCGAATTTATGACCCTGACGCGCGGGGTCGGGCTGATGAGCCACGTGTT
CGACGATTACGCGCCCGTCAAACCCGATATGCCCGGCCGCCACAACGGCGTGCTGGTGTCCCAAGAGCAGGGCGAGGCAG
TCGCTTACGCCTTGTGGAATCTGGAAGACCGCGGCCGTATGTTCGTATCGCCCAACGACAAAATCTACGAAGGTATGATT
ATCGGCATCCACAGTCGCGACAACGATTTGGTGGTCAACCCGCTCAAAGGCAAAAAACTTACCAACATCCGTGCCAGCGG
TACCGACGAAGCCGTTCGCCTGACCACGCCGATTAAGCTGACGCTGGAAGGTGCGGTCGAGTTTATCGACGATGATGAGC
TGGTAGAAATCACGCCGCAATCCATCCGTCTGCGCAAGCGTTACTTGAGCGAATTGGAACGCCGCCGCCACTTTAAAAAG
CTGGATTGA

Upstream 100 bases:

>100_bases
CATCATCGCCCACGTCGACCACGGCAAAACCACATTGGTCGACCAACTGCTGCGCCAATCCGGCACATTCCGCGCCAACC
AGCAGGTTGACGAGCGCGTG

Downstream 100 bases:

>100_bases
TGTTTACTGGATTAATGTTTAAATGATACGCGATGCCGTCTGAAAAATTTCAGACGGCATTTTTTATTCGGACGGGCTTT
GCGGCTTCTTGAAGCTGTTT

Product: GTP-binding protein

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDSNDLEKERGITILAKNTAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGLK
PIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPIVYASGLSGFAKLEETDESNDMRPLFDTILKYTPAPSGSAD
ETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMNHEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDI
GIGVTITDKDNPKGLPMLSVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGRG
ELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGRRRGELTNMESDGNGRTRLEYH
IPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPGRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMI
IGIHSRDNDLVVNPLKGKKLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFKK
LD

Sequences:

>Translated_562_residues
MDSNDLEKERGITILAKNTAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGLK
PIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPIVYASGLSGFAKLEETDESNDMRPLFDTILKYTPAPSGSAD
ETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMNHEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDI
GIGVTITDKDNPKGLPMLSVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGRG
ELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGRRRGELTNMESDGNGRTRLEYH
IPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPGRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMI
IGIHSRDNDLVVNPLKGKKLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFKK
LD
>Mature_562_residues
MDSNDLEKERGITILAKNTAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQEGPMPQTRFVTKKALALGLK
PIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPIVYASGLSGFAKLEETDESNDMRPLFDTILKYTPAPSGSAD
ETLQLQISQLDYDNYTGRLGIGRILNGRIKPGQTVAVMNHEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDI
GIGVTITDKDNPKGLPMLSVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTNVALRVEDTADADVFRVSGRG
ELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYENLTVDVPDDNQGAVMEELGRRRGELTNMESDGNGRTRLEYH
IPARGLIGFQGEFMTLTRGVGLMSHVFDDYAPVKPDMPGRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMI
IGIHSRDNDLVVNPLKGKKLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQSIRLRKRYLSELERRRHFKK
LD

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=461, Percent_Identity=25.1626898047722, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI94966754, Length=94, Percent_Identity=41.4893617021277, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI25306287, Length=122, Percent_Identity=37.7049180327869, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI19923640, Length=140, Percent_Identity=36.4285714285714, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI25306283, Length=140, Percent_Identity=36.4285714285714, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI18390331, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI34147630, Length=233, Percent_Identity=27.4678111587983, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI94966752, Length=83, Percent_Identity=42.1686746987952, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI48994988, Length=557, Percent_Identity=63.7342908438061, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=504, Percent_Identity=28.5714285714286, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1789738, Length=218, Percent_Identity=29.3577981651376, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790835, Length=100, Percent_Identity=31, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17557151, Length=202, Percent_Identity=30.1980198019802, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17533571, Length=134, Percent_Identity=37.3134328358209, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17556745, Length=410, Percent_Identity=23.6585365853659, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71988819, Length=90, Percent_Identity=41.1111111111111, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71988811, Length=90, Percent_Identity=41.1111111111111, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323320, Length=468, Percent_Identity=25.6410256410256, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323098, Length=136, Percent_Identity=40.4411764705882, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324707, Length=107, Percent_Identity=39.2523364485981, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320593, Length=107, Percent_Identity=39.2523364485981, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324761, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325337, Length=272, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319594, Length=272, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706572, Length=475, Percent_Identity=24.8421052631579, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24582462, Length=132, Percent_Identity=35.6060606060606, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281363316, Length=282, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17864358, Length=282, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 62591; Mature: 62591

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNDLEKERGITILAKNTAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQ
CCCCCCHHHCCEEEEEECCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHEEEEEEEECC
EGPMPQTRFVTKKALALGLKPIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPI
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCEE
VYASGLSGFAKLEETDESNDMRPLFDTILKYTPAPSGSADETLQLQISQLDYDNYTGRLG
EEECCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEE
IGRILNGRIKPGQTVAVMNHEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDI
EHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCC
GIGVTITDKDNPKGLPMLSVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTN
CEEEEEECCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHH
VALRVEDTADADVFRVSGRGELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYEN
HEEEEECCCCCCEEEECCCCCEEEEEEEEHHHCCCEEEECCCCEEEEECCCCCCCCCCCC
LTVDVPDDNQGAVMEELGRRRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGV
CEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCEEEEHHHH
GLMSHVFDDYAPVKPDMPGRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMI
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEEEECCCCCEEEEEE
IGIHSRDNDLVVNPLKGKKLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQ
EEEECCCCCEEEECCCCCEEEEEECCCCCCEEEEECCEEEEEEEEEEECCCCCEEEECHH
SIRLRKRYLSELERRRHFKKLD
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDSNDLEKERGITILAKNTAIDYEGYHINIVDTPGHADFGGEVERVLGMVDCVVLLVDAQ
CCCCCCHHHCCEEEEEECCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHEEEEEEEECC
EGPMPQTRFVTKKALALGLKPIVVINKIDKPSARPSWVIDQTFELFDNLGATDEQLDFPI
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCEE
VYASGLSGFAKLEETDESNDMRPLFDTILKYTPAPSGSADETLQLQISQLDYDNYTGRLG
EEECCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCEE
IGRILNGRIKPGQTVAVMNHEQQIAQGRINQLLGFKGLERVPLEEAEAGDIVIISGIEDI
EHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCC
GIGVTITDKDNPKGLPMLSVDEPTLTMDFMVNTSPLAGTEGKFVTSRQIRDRLQKELLTN
CEEEEEECCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHH
VALRVEDTADADVFRVSGRGELHLTILLENMRREGYELAVGKPRVVYRDIDGQKCEPYEN
HEEEEECCCCCCEEEECCCCCEEEEEEEEHHHCCCEEEECCCCEEEEECCCCCCCCCCCC
LTVDVPDDNQGAVMEELGRRRGELTNMESDGNGRTRLEYHIPARGLIGFQGEFMTLTRGV
CEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCEEEEHHHH
GLMSHVFDDYAPVKPDMPGRHNGVLVSQEQGEAVAYALWNLEDRGRMFVSPNDKIYEGMI
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCEEEECCCCCEEEEEE
IGIHSRDNDLVVNPLKGKKLTNIRASGTDEAVRLTTPIKLTLEGAVEFIDDDELVEITPQ
EEEECCCCCEEEECCCCCEEEEEECCCCCCEEEEECCEEEEEEEEEEECCCCCEEEECHH
SIRLRKRYLSELERRRHFKKLD
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]