Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 161869894

GI number: 161869894

Start: 928421

End: 929563

Strand: Direct

Name: clcA [H]

Synonym: NMCC_0925

Alternate gene names: 161869894

Gene position: 928421-929563 (Clockwise)

Preceding gene: 161869893

Following gene: 161869895

Centisome position: 43.11

GC content: 58.36

Gene sequence:

>1143_bases
ATGCACTTCATACAGCATACGGCATACGGTTATGGCGCGGACGGCGTGTACACTTCGTTCCGCGAAGGCGTGGCACAGGC
TTCCAGTATGCGGCGCGTTGTCGTGCTGACGCTGTGCGGCGCGGTCGCAGGAGTCGGCTGGTGCTTGCTGAAAGCCTTGG
GCAAGCCGCAAATCGAAATCAAAGCCGCCTTGAAGCAGCCGTTGCAGGGGCTGCCGTTTCTGACGACGGTTTTTCATGTT
CTGCTGCAAATCATAACGGTCGGACTCGGTTCGCCGCTCGGACGGGAAGTCGCGCCGCGTGAAATGACTGCCGCGTTTGC
TTTTGCCGGCGGCAGGCGGTTGGGTTTGGATGAAGACGAAATGCGCCTCTTGATTGCCTGTGCGTCCGGCGCGGGTTTGG
CAGCCGTGTATAATGTGCCGCTCGCCTCCACACTTTTCATCCTCGAAGCCATGCTGGGCGTGTGGACGCAGCAGGCGGTT
GCCGCCGCGTTGCTGACTTCCGTCATTGCCACCGCCGTGGCGCGTATCGGCTTAGGCGACGTACAGCAGTATCATCCCGC
CAACCTTGCCGTAAATACTTCATTGCTTTGGTTTTCCGCCGTCATCGGCCCGATATTGGGCGCAGCCGCCGTCTTTTTCC
AGCGTACCGCCCAAAAGTTCCCCTTTATCAAGCGCGACAACATCAAAATTATTCCCTTGGCAGTCTGCATGTTTGTGCTC
ATCGGCGCGATTGCCGTGTGGTTTCCCGAAATTTTGGGCAACGGCAAAGCAGGCAACCAACTGACTTTTAGTGGTTTGAC
CGGTTGGCAATACGCTTTGGAACTTGCAGCCGTCAAATGGCTGGTCGTCTTGATGGCGCTGGCGGCAGGCGCATACGGCG
GCCTGATTACGCCGTCTATGATGCTCGGCAGCACCATTTCTTTTGCAGCCGCCGCCGCGTGGAACAGCGTTTTCCCCGCA
ATGTCGTCTGAAAGCGCGGCAGTCGTCGGAGCGGCGGTGTTTCTCGGCGTGTCGCTCAAAATGCCGCTGACCGCCATTGT
GTTCGTATTGGAACTGACCTACGCGCCGCTGTCCCTGCTGCTGCCTTTGTGCATCGGCATGGCGGGGGCATTGGGAACAT
CGGGAAAAATGGGCTTCAAATGA

Upstream 100 bases:

>100_bases
TTGAACGGCAGGAACGACAGTGGGACGCAGAAAACTTTGGTTTGCCCTGGCAGCAGCAGGCGTTATCGGCGGTTTGGTCG
GCATTGTGCTGACGGAACTG

Downstream 100 bases:

>100_bases
ATGCCGACAAATGCCGTCTGAAAGGTTTTCAGACGGCATTTCTTTGTAAATTGTCAGCAATATCTGCAAAAACCTACTGC
CAAAAAACTAGAAATAGCGG

Product: chloride channel protein-related protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MHFIQHTAYGYGADGVYTSFREGVAQASSMRRVVVLTLCGAVAGVGWCLLKALGKPQIEIKAALKQPLQGLPFLTTVFHV
LLQIITVGLGSPLGREVAPREMTAAFAFAGGRRLGLDEDEMRLLIACASGAGLAAVYNVPLASTLFILEAMLGVWTQQAV
AAALLTSVIATAVARIGLGDVQQYHPANLAVNTSLLWFSAVIGPILGAAAVFFQRTAQKFPFIKRDNIKIIPLAVCMFVL
IGAIAVWFPEILGNGKAGNQLTFSGLTGWQYALELAAVKWLVVLMALAAGAYGGLITPSMMLGSTISFAAAAAWNSVFPA
MSSESAAVVGAAVFLGVSLKMPLTAIVFVLELTYAPLSLLLPLCIGMAGALGTSGKMGFK

Sequences:

>Translated_380_residues
MHFIQHTAYGYGADGVYTSFREGVAQASSMRRVVVLTLCGAVAGVGWCLLKALGKPQIEIKAALKQPLQGLPFLTTVFHV
LLQIITVGLGSPLGREVAPREMTAAFAFAGGRRLGLDEDEMRLLIACASGAGLAAVYNVPLASTLFILEAMLGVWTQQAV
AAALLTSVIATAVARIGLGDVQQYHPANLAVNTSLLWFSAVIGPILGAAAVFFQRTAQKFPFIKRDNIKIIPLAVCMFVL
IGAIAVWFPEILGNGKAGNQLTFSGLTGWQYALELAAVKWLVVLMALAAGAYGGLITPSMMLGSTISFAAAAAWNSVFPA
MSSESAAVVGAAVFLGVSLKMPLTAIVFVLELTYAPLSLLLPLCIGMAGALGTSGKMGFK
>Mature_380_residues
MHFIQHTAYGYGADGVYTSFREGVAQASSMRRVVVLTLCGAVAGVGWCLLKALGKPQIEIKAALKQPLQGLPFLTTVFHV
LLQIITVGLGSPLGREVAPREMTAAFAFAGGRRLGLDEDEMRLLIACASGAGLAAVYNVPLASTLFILEAMLGVWTQQAV
AAALLTSVIATAVARIGLGDVQQYHPANLAVNTSLLWFSAVIGPILGAAAVFFQRTAQKFPFIKRDNIKIIPLAVCMFVL
IGAIAVWFPEILGNGKAGNQLTFSGLTGWQYALELAAVKWLVVLMALAAGAYGGLITPSMMLGSTISFAAAAAWNSVFPA
MSSESAAVVGAAVFLGVSLKMPLTAIVFVLELTYAPLSLLLPLCIGMAGALGTSGKMGFK

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 39737; Mature: 39737

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFIQHTAYGYGADGVYTSFREGVAQASSMRRVVVLTLCGAVAGVGWCLLKALGKPQIEI
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KAALKQPLQGLPFLTTVFHVLLQIITVGLGSPLGREVAPREMTAAFAFAGGRRLGLDEDE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHH
MRLLIACASGAGLAAVYNVPLASTLFILEAMLGVWTQQAVAAALLTSVIATAVARIGLGD
HEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VQQYHPANLAVNTSLLWFSAVIGPILGAAAVFFQRTAQKFPFIKRDNIKIIPLAVCMFVL
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEHHHHHHHHH
IGAIAVWFPEILGNGKAGNQLTFSGLTGWQYALELAAVKWLVVLMALAAGAYGGLITPSM
HHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
MLGSTISFAAAAAWNSVFPAMSSESAAVVGAAVFLGVSLKMPLTAIVFVLELTYAPLSLL
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LPLCIGMAGALGTSGKMGFK
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHFIQHTAYGYGADGVYTSFREGVAQASSMRRVVVLTLCGAVAGVGWCLLKALGKPQIEI
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KAALKQPLQGLPFLTTVFHVLLQIITVGLGSPLGREVAPREMTAAFAFAGGRRLGLDEDE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHH
MRLLIACASGAGLAAVYNVPLASTLFILEAMLGVWTQQAVAAALLTSVIATAVARIGLGD
HEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VQQYHPANLAVNTSLLWFSAVIGPILGAAAVFFQRTAQKFPFIKRDNIKIIPLAVCMFVL
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEHHHHHHHHH
IGAIAVWFPEILGNGKAGNQLTFSGLTGWQYALELAAVKWLVVLMALAAGAYGGLITPSM
HHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
MLGSTISFAAAAAWNSVFPAMSSESAAVVGAAVFLGVSLKMPLTAIVFVLELTYAPLSLL
HHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LPLCIGMAGALGTSGKMGFK
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA