Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 161869771

GI number: 161869771

Start: 804963

End: 807227

Strand: Reverse

Name: clpA [H]

Synonym: NMCC_0794

Alternate gene names: 161869771

Gene position: 807227-804963 (Counterclockwise)

Preceding gene: 161869772

Following gene: 161869763

Centisome position: 37.49

GC content: 55.98

Gene sequence:

>2265_bases
ATGCTTGCACCCGAATTGGAACAGATTTTGCAGCAGCTTTACCGCGAGGCGCGTAAGGCTCATTATGAATTTATCAGCCT
CGAGCATCTGCTTTTGGTACTCATCGAAGAAGATGCCTCCGTGCCGAACGTCTTAAAACTATGCGGCGCGGATTTGAAAG
TGGTGTCCGAACAGCTCGCCGCCAGCGTTGCCGAAAACACCCCCCTGATTCCCGAACACCTTTTAGACACGGTCGAAACA
CGGCCCACGCTCGGCTTCCAACGCGTGATGCAACGGGCGATGGTGCATACCCAGTCTGCCGGAAAAGCCGCAGTCGAACC
GTTGGACGTTTTGGTCGCGCTGATGAGCGAAACCGACAGCCACACCGTCTATTTCCTCAAGCTGCAATCGGTTACGCGTT
TTGAAGTTTTGCGCTGTATTGCCCACGGCTCGCCCGATGACGAGGATGGCAATGATTCAGACGGCCTGGGACGCGAGGGC
GAAGAAGCGGAACAAAAAACCGGCTCCCTTTCCGACTACACCGTCAACCTCAACGCCGAAGTCAAAGCCGGCCGTATCGA
CCCTTTGATTGGTCGCAAACACGAAATGGAACGGCTGGTGCAAATCCTGTGCCGCCGCCGCAAAAACAATCCGCTTTTGG
TCGGCGAAGCAGGTGTGGGCAAAACCGCGCTGGCGGAAGGTTTGGCACATCAAATCGTCAACAGCGACATTCCCGACGCG
CTCAAAGATACCGAAGTGTACGCGCTGGATATGGGTTCGCTGTTGGCGGGCACGAAATACCGCGGCGACTTTGAAGCGCG
GGTCAAATCCGTCTTGAAACAGCTCGAAAAAATCCCGCACGCCATTTTGTTTATCGACGAAATCCACACCATCATCGGCG
CGGGCAGCACCAGCGGCGGCACCATGGACGCGTCCAACCTGCTCAAACCCGCGCTGGCAAAAGGTTCGCTGCGCTGCATC
GGCGCGACCACCTACGACGAATACCGCACCATTTTCGACAAAGACCATGCCTTAAGCCGCCGCTTCCAAAAAATCGACGT
GGTCGAACCCACCGTTTCCGAAACCGTTCAAATCCTGCGCGGCTTGAAACCGATGTTTGAAGCCTTCCACCAAGTCCGCT
ACACTCAAGGCGCACTCGAAGCCGCCGCCGAACTCTCCGCACGCTACATCAACGAGCGTTTCCTGCCCGACAAAGCCATC
GACGTAATGGATGAAGCAGGCGCGGCGCAACGGATTCTGCCCAAATCCAAACAGAAAAAAGTCATCGGCAAAGCACAAAT
CGAAACCGTCATCGCCAAAGTTTCGCGGATTCCCGAAAAAACCGTGTCGCACGACGACAAACAAGTGCTGCAATTCCTCG
GTCGCGATTTGAAAAACATGGTTTACGGTCAAGAAAACGCCATCGACGCGCTGGTTGCCGCCGTCAAAATGTCGCGTTCC
GGCCTTGCCCTGCCCGACAAACCGATAGGCAGCTTCCTCTTCTCCGGCCCGACCGGCGTGGGCAAAACCGAAGCCGCCAA
ACAGCTTGCCTACTCGCTGGGCGTACCGCTGCAACGCTTTGATATGTCCGAATACATGGAACGCCATGCCGTATCGCGCC
TCATCGGCGCGCCACCGGGCTACGTCGGCTTTGAACAAGGCGGCCTTTTGACCGAAGCCGTCAACAAACAGCCGCATTGC
GTATTGCTCTTGGACGAAATCGAAAAAGCCCACCCCGACATTTTCAACGTCCTCCTGCAAGTCATGGACGCAGGCAAACT
GACCGACAACAACGGCAAGAGTGCCGATTTCCGCAACGTCATCCTGATTATGACCACCAACGCAGGCGCGGAAAGCCTCA
GCCGCCCCAGCCTCGGCTTTACCGCCAAGCGCGAACGCGGCGACGAAATGCAGGCAATCAACAAGCTCTTCACGCCCGAG
TTCCGCAACCGCTTGGACGCGATTATCCCGTTTGCGCCCTTGTCCGAACCCATCATCGTCAAAGTCGTGGACAAATTCCT
GCTCCAGCTCGAACACCAGCTCCTCGACAAAAAAGTCGAAGCCGAATTCACGTCGGCATTGCACAAATATCTGGCGGAAA
AAGGTTTCGACCCGCAAATGGGCGCGCGCCCGATGCACCGCCTGATTCAGGAAAAAATCCGCAAACCGCTCGCCGACGAA
CTCCTGTTCGGCAAACTCGCCGACGGCGGCTTTGTGCGGATAGACTGGGATACGGCAAAAGAAGAAGCCGTGTTGAAGTT
TAAGAAAAGCAAGGTCAAAATGTAG

Upstream 100 bases:

>100_bases
ACTTACACGCGCGATATTGCCCAAACCAAACAGCAACAAGTCATGCAGCGGGCAAAAGCCGAAGGGCATCCGCTGCAATG
TATTGTCGAGGAGATTTAAT

Downstream 100 bases:

>100_bases
TGGATTAACAAAAACCAGTACGGCGTTGCCTCGCCTTAGCTCAAAGAGAACGATTCTCTAAGGTGCTGAAGCACCAAGTG
AATCGGTTCCGTACTATTTG

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MLAPELEQILQQLYREARKAHYEFISLEHLLLVLIEEDASVPNVLKLCGADLKVVSEQLAASVAENTPLIPEHLLDTVET
RPTLGFQRVMQRAMVHTQSAGKAAVEPLDVLVALMSETDSHTVYFLKLQSVTRFEVLRCIAHGSPDDEDGNDSDGLGREG
EEAEQKTGSLSDYTVNLNAEVKAGRIDPLIGRKHEMERLVQILCRRRKNNPLLVGEAGVGKTALAEGLAHQIVNSDIPDA
LKDTEVYALDMGSLLAGTKYRGDFEARVKSVLKQLEKIPHAILFIDEIHTIIGAGSTSGGTMDASNLLKPALAKGSLRCI
GATTYDEYRTIFDKDHALSRRFQKIDVVEPTVSETVQILRGLKPMFEAFHQVRYTQGALEAAAELSARYINERFLPDKAI
DVMDEAGAAQRILPKSKQKKVIGKAQIETVIAKVSRIPEKTVSHDDKQVLQFLGRDLKNMVYGQENAIDALVAAVKMSRS
GLALPDKPIGSFLFSGPTGVGKTEAAKQLAYSLGVPLQRFDMSEYMERHAVSRLIGAPPGYVGFEQGGLLTEAVNKQPHC
VLLLDEIEKAHPDIFNVLLQVMDAGKLTDNNGKSADFRNVILIMTTNAGAESLSRPSLGFTAKRERGDEMQAINKLFTPE
FRNRLDAIIPFAPLSEPIIVKVVDKFLLQLEHQLLDKKVEAEFTSALHKYLAEKGFDPQMGARPMHRLIQEKIRKPLADE
LLFGKLADGGFVRIDWDTAKEEAVLKFKKSKVKM

Sequences:

>Translated_754_residues
MLAPELEQILQQLYREARKAHYEFISLEHLLLVLIEEDASVPNVLKLCGADLKVVSEQLAASVAENTPLIPEHLLDTVET
RPTLGFQRVMQRAMVHTQSAGKAAVEPLDVLVALMSETDSHTVYFLKLQSVTRFEVLRCIAHGSPDDEDGNDSDGLGREG
EEAEQKTGSLSDYTVNLNAEVKAGRIDPLIGRKHEMERLVQILCRRRKNNPLLVGEAGVGKTALAEGLAHQIVNSDIPDA
LKDTEVYALDMGSLLAGTKYRGDFEARVKSVLKQLEKIPHAILFIDEIHTIIGAGSTSGGTMDASNLLKPALAKGSLRCI
GATTYDEYRTIFDKDHALSRRFQKIDVVEPTVSETVQILRGLKPMFEAFHQVRYTQGALEAAAELSARYINERFLPDKAI
DVMDEAGAAQRILPKSKQKKVIGKAQIETVIAKVSRIPEKTVSHDDKQVLQFLGRDLKNMVYGQENAIDALVAAVKMSRS
GLALPDKPIGSFLFSGPTGVGKTEAAKQLAYSLGVPLQRFDMSEYMERHAVSRLIGAPPGYVGFEQGGLLTEAVNKQPHC
VLLLDEIEKAHPDIFNVLLQVMDAGKLTDNNGKSADFRNVILIMTTNAGAESLSRPSLGFTAKRERGDEMQAINKLFTPE
FRNRLDAIIPFAPLSEPIIVKVVDKFLLQLEHQLLDKKVEAEFTSALHKYLAEKGFDPQMGARPMHRLIQEKIRKPLADE
LLFGKLADGGFVRIDWDTAKEEAVLKFKKSKVKM
>Mature_754_residues
MLAPELEQILQQLYREARKAHYEFISLEHLLLVLIEEDASVPNVLKLCGADLKVVSEQLAASVAENTPLIPEHLLDTVET
RPTLGFQRVMQRAMVHTQSAGKAAVEPLDVLVALMSETDSHTVYFLKLQSVTRFEVLRCIAHGSPDDEDGNDSDGLGREG
EEAEQKTGSLSDYTVNLNAEVKAGRIDPLIGRKHEMERLVQILCRRRKNNPLLVGEAGVGKTALAEGLAHQIVNSDIPDA
LKDTEVYALDMGSLLAGTKYRGDFEARVKSVLKQLEKIPHAILFIDEIHTIIGAGSTSGGTMDASNLLKPALAKGSLRCI
GATTYDEYRTIFDKDHALSRRFQKIDVVEPTVSETVQILRGLKPMFEAFHQVRYTQGALEAAAELSARYINERFLPDKAI
DVMDEAGAAQRILPKSKQKKVIGKAQIETVIAKVSRIPEKTVSHDDKQVLQFLGRDLKNMVYGQENAIDALVAAVKMSRS
GLALPDKPIGSFLFSGPTGVGKTEAAKQLAYSLGVPLQRFDMSEYMERHAVSRLIGAPPGYVGFEQGGLLTEAVNKQPHC
VLLLDEIEKAHPDIFNVLLQVMDAGKLTDNNGKSADFRNVILIMTTNAGAESLSRPSLGFTAKRERGDEMQAINKLFTPE
FRNRLDAIIPFAPLSEPIIVKVVDKFLLQLEHQLLDKKVEAEFTSALHKYLAEKGFDPQMGARPMHRLIQEKIRKPLADE
LLFGKLADGGFVRIDWDTAKEEAVLKFKKSKVKM

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=297, Percent_Identity=32.6599326599327, Blast_Score=153, Evalue=5e-37,
Organism=Escherichia coli, GI1787109, Length=753, Percent_Identity=56.0424966799469, Blast_Score=862, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=398, Percent_Identity=42.964824120603, Blast_Score=285, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=267, Percent_Identity=55.4307116104869, Blast_Score=276, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=402, Percent_Identity=36.81592039801, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83378; Mature: 83378

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAPELEQILQQLYREARKAHYEFISLEHLLLVLIEEDASVPNVLKLCGADLKVVSEQLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHH
ASVAENTPLIPEHLLDTVETRPTLGFQRVMQRAMVHTQSAGKAAVEPLDVLVALMSETDS
HHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
HTVYFLKLQSVTRFEVLRCIAHGSPDDEDGNDSDGLGREGEEAEQKTGSLSDYTVNLNAE
CEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCE
VKAGRIDPLIGRKHEMERLVQILCRRRKNNPLLVGEAGVGKTALAEGLAHQIVNSDIPDA
EECCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCH
LKDTEVYALDMGSLLAGTKYRGDFEARVKSVLKQLEKIPHAILFIDEIHTIIGAGSTSGG
HHCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
TMDASNLLKPALAKGSLRCIGATTYDEYRTIFDKDHALSRRFQKIDVVEPTVSETVQILR
CCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKPMFEAFHQVRYTQGALEAAAELSARYINERFLPDKAIDVMDEAGAAQRILPKSKQKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCHHHHH
VIGKAQIETVIAKVSRIPEKTVSHDDKQVLQFLGRDLKNMVYGQENAIDALVAAVKMSRS
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GLALPDKPIGSFLFSGPTGVGKTEAAKQLAYSLGVPLQRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCC
YVGFEQGGLLTEAVNKQPHCVLLLDEIEKAHPDIFNVLLQVMDAGKLTDNNGKSADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
ILIMTTNAGAESLSRPSLGFTAKRERGDEMQAINKLFTPEFRNRLDAIIPFAPLSEPIIV
EEEEECCCCHHHCCCCCCCCCCCHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH
KVVDKFLLQLEHQLLDKKVEAEFTSALHKYLAEKGFDPQMGARPMHRLIQEKIRKPLADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHH
LLFGKLADGGFVRIDWDTAKEEAVLKFKKSKVKM
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLAPELEQILQQLYREARKAHYEFISLEHLLLVLIEEDASVPNVLKLCGADLKVVSEQLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHH
ASVAENTPLIPEHLLDTVETRPTLGFQRVMQRAMVHTQSAGKAAVEPLDVLVALMSETDS
HHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
HTVYFLKLQSVTRFEVLRCIAHGSPDDEDGNDSDGLGREGEEAEQKTGSLSDYTVNLNAE
CEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEECCE
VKAGRIDPLIGRKHEMERLVQILCRRRKNNPLLVGEAGVGKTALAEGLAHQIVNSDIPDA
EECCCCCCHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCH
LKDTEVYALDMGSLLAGTKYRGDFEARVKSVLKQLEKIPHAILFIDEIHTIIGAGSTSGG
HHCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
TMDASNLLKPALAKGSLRCIGATTYDEYRTIFDKDHALSRRFQKIDVVEPTVSETVQILR
CCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKPMFEAFHQVRYTQGALEAAAELSARYINERFLPDKAIDVMDEAGAAQRILPKSKQKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCHHHHH
VIGKAQIETVIAKVSRIPEKTVSHDDKQVLQFLGRDLKNMVYGQENAIDALVAAVKMSRS
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GLALPDKPIGSFLFSGPTGVGKTEAAKQLAYSLGVPLQRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCC
YVGFEQGGLLTEAVNKQPHCVLLLDEIEKAHPDIFNVLLQVMDAGKLTDNNGKSADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
ILIMTTNAGAESLSRPSLGFTAKRERGDEMQAINKLFTPEFRNRLDAIIPFAPLSEPIIV
EEEEECCCCHHHCCCCCCCCCCCHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH
KVVDKFLLQLEHQLLDKKVEAEFTSALHKYLAEKGFDPQMGARPMHRLIQEKIRKPLADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHH
LLFGKLADGGFVRIDWDTAKEEAVLKFKKSKVKM
HHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]