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The map label for this gene is ppiB [H]

Identifier: 161869737

GI number: 161869737

Start: 763478

End: 763987

Strand: Reverse

Name: ppiB [H]

Synonym: NMCC_0757

Alternate gene names: 161869737

Gene position: 763987-763478 (Counterclockwise)

Preceding gene: 161869738

Following gene: 161869736

Centisome position: 35.48

GC content: 50.39

Gene sequence:

>510_bases
ATGATTATCCTGCACACCAACAAAGGCGACATCAAAATCGAACTCGATTTCGACAAAGCCCCCGTTACTGCTAAAAACTT
CGAGCAATACGTTAAAGACGGCTTCTACGACGGCGTAATCTTCCACCGCGTTATCAAAGGCTTCATGATTCAAGGCGGCG
GCATGGATGAAAACATGAACGAAAAAGAAACCCGCGATCCGATTCAAAACGAAGCGTCCAACGGCCTGCCCAACGATAAA
TACACCATCGCCATGGCACGCACTTCCGACCCCCATTCCGCCAGCGCGCAATTCTTCATCAACACTGCCGACAACGCTTT
CCTGAACTTCCGTTCTAAAGAGCTGTACGGCAAAACCGTCGTCCAAGACTGGGGCTATGCAGTATTCGGTAAAGTCGTTG
ACGGTTTTGACGTTGTCGATGCCATCGAAGGCGTATCCACCAAACGCCACGGCTACCATGACGACGTACCGAGCGAACCT
GTCGTCATCATTAAAGCCGAAGCGGTATAA

Upstream 100 bases:

>100_bases
AAGACCGTCTGAAAGAATATTTTTCAGACGACCTTGAAGTTTGTCGTTCAGACACAATTTGTCGAATCATTCAAAACCGG
ATTCTAACGAAAGGAAACCC

Downstream 100 bases:

>100_bases
ACCGGCAATCCGAAAGCAGCCTGCACAAAGGCTGCTTTTTTTGTTTCAGGCGGCATAAAATCCAAGCACATATGCCGTCT
GAACACCTCCCGCAAGCCTT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MIILHTNKGDIKIELDFDKAPVTAKNFEQYVKDGFYDGVIFHRVIKGFMIQGGGMDENMNEKETRDPIQNEASNGLPNDK
YTIAMARTSDPHSASAQFFINTADNAFLNFRSKELYGKTVVQDWGYAVFGKVVDGFDVVDAIEGVSTKRHGYHDDVPSEP
VVIIKAEAV

Sequences:

>Translated_169_residues
MIILHTNKGDIKIELDFDKAPVTAKNFEQYVKDGFYDGVIFHRVIKGFMIQGGGMDENMNEKETRDPIQNEASNGLPNDK
YTIAMARTSDPHSASAQFFINTADNAFLNFRSKELYGKTVVQDWGYAVFGKVVDGFDVVDAIEGVSTKRHGYHDDVPSEP
VVIIKAEAV
>Mature_169_residues
MIILHTNKGDIKIELDFDKAPVTAKNFEQYVKDGFYDGVIFHRVIKGFMIQGGGMDENMNEKETRDPIQNEASNGLPNDK
YTIAMARTSDPHSASAQFFINTADNAFLNFRSKELYGKTVVQDWGYAVFGKVVDGFDVVDAIEGVSTKRHGYHDDVPSEP
VVIIKAEAV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=148, Percent_Identity=36.4864864864865, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI7657473, Length=148, Percent_Identity=36.4864864864865, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=35.8024691358025, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI19557636, Length=154, Percent_Identity=33.1168831168831, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=31.7647058823529, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI5454154, Length=169, Percent_Identity=34.9112426035503, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=58.8957055214724, Blast_Score=197, Evalue=4e-52,
Organism=Escherichia coli, GI1789763, Length=168, Percent_Identity=54.1666666666667, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=35.6164383561644, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=35.6164383561644, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=31.1377245508982, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=166, Percent_Identity=33.7349397590361, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17986117, Length=171, Percent_Identity=32.7485380116959, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19922912, Length=141, Percent_Identity=35.4609929078014, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652460, Length=171, Percent_Identity=29.2397660818713, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922376, Length=173, Percent_Identity=30.0578034682081, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18852; Mature: 18852

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILHTNKGDIKIELDFDKAPVTAKNFEQYVKDGFYDGVIFHRVIKGFMIQGGGMDENMN
CEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
EKETRDPIQNEASNGLPNDKYTIAMARTSDPHSASAQFFINTADNAFLNFRSKELYGKTV
CHHHCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEECCHHHHCHHH
VQDWGYAVFGKVVDGFDVVDAIEGVSTKRHGYHDDVPSEPVVIIKAEAV
HHHCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIILHTNKGDIKIELDFDKAPVTAKNFEQYVKDGFYDGVIFHRVIKGFMIQGGGMDENMN
CEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCC
EKETRDPIQNEASNGLPNDKYTIAMARTSDPHSASAQFFINTADNAFLNFRSKELYGKTV
CHHHCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEECCHHHHCHHH
VQDWGYAVFGKVVDGFDVVDAIEGVSTKRHGYHDDVPSEPVVIIKAEAV
HHHCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]