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The map label for this gene is ispH [H]

Identifier: 161869384

GI number: 161869384

Start: 397578

End: 398546

Strand: Direct

Name: ispH [H]

Synonym: NMCC_0391

Alternate gene names: 161869384

Gene position: 397578-398546 (Clockwise)

Preceding gene: 161869383

Following gene: 161869392

Centisome position: 18.46

GC content: 57.38

Gene sequence:

>969_bases
ATGAACGGAAAAACCATCATCCTTGCCAATCCGCGCGGCTTCTGCGCCGGCGTGGATCGGGCAATCAGTATTGTCGAGCG
TGCTTTGGAAGAATTCGGCGCGCCGATTTATGTGCGCCACGAAGTCGTCCACAACAAATTCGTCGTCGATAACCTGCGTG
AAAAAGGCGCGGTGTTTATCGAAGACTTGGCGGAAGTGCCGCCGGGCGCGACGCTGATTTATTCGGCACACGGTGTATCG
AAGGCGGTGCAGCAGGAAGCGGCGGAGCGCGGTTTCCGCGTGTTTGATGCGACTTGCCCGCTGGTTACGAAAGTGCATAA
GGAAGTCGCCCGACTGGATGCCCAAGACTGTGAAATCATCATGATCGGGCATAAGGGGCACGTTGAGGTCGAAGGAACGA
TGGGGCAGCTTGCGCCGGGCAAAATGCTTTTGGTCGAAACGGTCGGAGATGTGGCAAAACTCGAAGTCAGAAACCCCGAC
AAACTCGCCTATGTCAGCCAAACCACGCTCTCGGTCGATGAAACCAAAGACATCATTGCCGCGCTGAACGCGCGTTTCCC
CAATATCCGCAATCCGCACAAGGAAGACATCTGCTATGCGACGACCAACCGGCAAACCGCCGTCAAAGAGCTGGCGGAAC
AGTGCGACATCGTGATTGTGGTCGGTTCGCCCAATTCGTCCAACAGCAATCGCCTGCGCGAAGTGGCGGCAGGCATCGGG
ACCGATGCGTATATGGTGGACAACGCGTCCTACCTGCAACGCGCGTGGTTTGAGGGCAAAAACAAAGTCGGCGTAACGGC
AGGCGCGTCCGCGCCCGAAGTGTTGGTGCAGGAAGTACTGGCAACCATACGCAGATGGGGGCACGAAACCGTACGCGAAG
GGGAGGGCGCGGAAGAAAGCATTGTGTTCGTCCTGCCCAAAGAGCTGCGCCGCGAGGGCGAAACCAAACCCGATTTGTGC
AAACGTTGA

Upstream 100 bases:

>100_bases
TTATCTGCGTCGGTGCGGTGTTGGCGGTGTTGGACAATATCGTCCATCGCAAAGATGGCAAAAAAACGTGAATGCCGTCT
GAACACGGAATGTAAAACTT

Downstream 100 bases:

>100_bases
GCAAGCGTCGGATGTTTGGGCAACACAAATGCCGTCTGAACAGGCTTCAGACGGCATTTTTGCCGCGTGCCGGATGCGGA
AACCGATCAGGCGTAATGTC

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFIEDLAEVPPGATLIYSAHGVS
KAVQQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEIIMIGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPD
KLAYVSQTTLSVDETKDIIAALNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAAGIG
TDAYMVDNASYLQRAWFEGKNKVGVTAGASAPEVLVQEVLATIRRWGHETVREGEGAEESIVFVLPKELRREGETKPDLC
KR

Sequences:

>Translated_322_residues
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFIEDLAEVPPGATLIYSAHGVS
KAVQQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEIIMIGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPD
KLAYVSQTTLSVDETKDIIAALNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAAGIG
TDAYMVDNASYLQRAWFEGKNKVGVTAGASAPEVLVQEVLATIRRWGHETVREGEGAEESIVFVLPKELRREGETKPDLC
KR
>Mature_322_residues
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFIEDLAEVPPGATLIYSAHGVS
KAVQQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEIIMIGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPD
KLAYVSQTTLSVDETKDIIAALNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAAGIG
TDAYMVDNASYLQRAWFEGKNKVGVTAGASAPEVLVQEVLATIRRWGHETVREGEGAEESIVFVLPKELRREGETKPDLC
KR

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=307, Percent_Identity=62.5407166123778, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35253; Mature: 35253

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFI
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCHH
EDLAEVPPGATLIYSAHGVSKAVQQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEII
HHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCEE
MIGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPDKLAYVSQTTLSVDETKDIIA
EECCCCCEEECCCCCCCCCCCEEEEEHHCCCEEEEECCCCCEEEEECCEECHHHHHHHHH
ALNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAAGIG
HHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCC
TDAYMVDNASYLQRAWFEGKNKVGVTAGASAPEVLVQEVLATIRRWGHETVREGEGAEES
CCEEEECCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCC
IVFVLPKELRREGETKPDLCKR
EEEEECHHHHHCCCCCCHHHCC
>Mature Secondary Structure
MNGKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFI
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCHH
EDLAEVPPGATLIYSAHGVSKAVQQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEII
HHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCEE
MIGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPDKLAYVSQTTLSVDETKDIIA
EECCCCCEEECCCCCCCCCCCEEEEEHHCCCEEEEECCCCCEEEEECCEECHHHHHHHHH
ALNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAAGIG
HHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHCC
TDAYMVDNASYLQRAWFEGKNKVGVTAGASAPEVLVQEVLATIRRWGHETVREGEGAEES
CCEEEECCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCC
IVFVLPKELRREGETKPDLCKR
EEEEECHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA