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The map label for this gene is lspA [H]

Identifier: 161869383

GI number: 161869383

Start: 397054

End: 397548

Strand: Direct

Name: lspA [H]

Synonym: NMCC_0390

Alternate gene names: 161869383

Gene position: 397054-397548 (Clockwise)

Preceding gene: 161869382

Following gene: 161869384

Centisome position: 18.44

GC content: 51.52

Gene sequence:

>495_bases
ATGTCTTCATCTGTTTCAAGTAAAACGCGCTATTGGGTATTGGCACTTGCCGCCATCGTGCTGGACCAGTGGTCGAAGTG
GGCGGTGCTGTCGTCGTTTCAGTATCGGGAACGCGTCAATGTCATTCCTTCGTTTTTCGATCTGACCTTGGTGTACAACC
CGGGCGCGGCGTTCAGCTTCCTTGCCGATCAGGGCGGCTGGCAAAAATACTTTTTTTTGGTGCTGGCGGTGGCGGTGAGC
GCGTATTTGGTACGCGCCATCTTGCGCGATGAGTTTGCAACCCTCGGCAAAACGGGTGCGGCGATGATTATCGGCGGTGC
GTTAGGCAATGTCATCGATCGCCTGATACACGGTCATGTCGTCGATTTCTTATTGTTTTATTGGCAAAATTGGTTTTATC
CCGCCTTTAATATTGCCGACAGCTTTATCTGCGTCGGTGCGGTGTTGGCGGTGTTGGACAATATCGTCCATCGCAAAGAT
GGCAAAAAAACGTGA

Upstream 100 bases:

>100_bases
TCGGGAATGACGGGTTTCAAGATTCCGGCATTTGCCGTTTCGGGTACAGGCAGGGGGTTTTCGGGTAAAATGGCACTCTT
TTATCCGGCTGTTGAAAAAT

Downstream 100 bases:

>100_bases
ATGCCGTCTGAACACGGAATGTAAAACTTATGAACGGAAAAACCATCATCCTTGCCAATCCGCGCGGCTTCTGCGCCGGC
GTGGATCGGGCAATCAGTAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLVLAVAVS
AYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKD
GKKT

Sequences:

>Translated_164_residues
MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLVLAVAVS
AYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKD
GKKT
>Mature_163_residues
SSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLVLAVAVSA
YLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKDG
KKT

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=165, Percent_Identity=41.8181818181818, Blast_Score=120, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18350; Mature: 18219

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSF
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCHHHH
LADQGGWQKYFFLVLAVAVSAYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKDGKKT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSF
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCHHHH
LADQGGWQKYFFLVLAVAVSAYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKDGKKT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]