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The map label for this gene is dxs [H]

Identifier: 161869348

GI number: 161869348

Start: 354147

End: 356054

Strand: Direct

Name: dxs [H]

Synonym: NMCC_0354

Alternate gene names: 161869348

Gene position: 354147-356054 (Clockwise)

Preceding gene: 161869347

Following gene: 161869350

Centisome position: 16.45

GC content: 58.6

Gene sequence:

>1908_bases
ATGAACCCAAGCCCCCTACTCGACCTGATTGACAGCCCGCAAGATTTGCGCCGTCTGGACAAAAAACAGCTGCCGCGCCT
TGCCGGCGAGTTGCGCACCTTTCTGCTGGAATCTGTCGGGCAGACCGGCGGGCATTTCGCCAGCAATTTGGGCGCGGTCG
AACTGACCATCGCCCTGCACTATGTGTACGACACGCCCGAAGACAAGCTGGTGTGGGATGTCGGACACCAAAGCTATCCG
CACAAAATCCTGACAGGCAGGAAAAACCAGATGCACACCATGCGCCAATATGGCGGTTTGGCGGGTTTTCCGAAACGTTG
CGAGTCCGAGTACGACGCGTTCGGCGTGGGGCATTCCTCCACCTCCATCGGCGCGGCGTTGGGCATGGCGGCGGCAGACA
AACTCTTGGGCAGCGACCGCCGCAGCGTCGCCATCATCGGCGACGGCGCGATGACGGCGGGGCAGGCGTTTGAAGCCTTG
AATTGCGCAGGCGATATGGATGTGGATTTGCTGGTCGTCCTCAACGACAACGAAATGTCGATTTCCCCCAACGTCGGCGC
GCTGCCGAAATACCTTGCCAGCAACGTCGTGCGCGATATGCACGGCCTGTTGAGTACCGTCAAAGCGCAAACGGGCAAGG
TATTAGACAAAATACCCGGCGCGATGGAGTTTGCCCAAAAAGTCGAACACAAAATCAAAACCCTTGCCGAAGAAGCCGAA
CACGCCAAACAGTCGCTGTCTTTGTTTGAAAACTTCGGCTTCCGCTACACCGGCCCCGTGGACGGACACAACGTCGAAAA
TCTGGTGGACGTATTGAAAGACTTGCGCAGCCGCAAAGGCCCTCAACTGCTGCACGTCATCACCAAAAAGGGCAACGGCT
ACAAACTCGCCGAAAACGACCCCGTCAAATACCACGCCGTCGCCAACCTGCCCAAAGAAAGCGCGGCGCAAATGCCGTCT
GAAAACAAACCTGCCGCCAAACCGACCTATACCCAAGTGTTCGGCAAATGGCTGTGCGACCGGGCGGCGGCAGATTCCCG
ACTGGTTGCGATTACCCCCGCCATGCGCGAGGGCAGCGGCTTGGTTGAGTTTGAACAACGATTCCCCGACCGCTATTTCG
ACGTCGGCATTGCCGAGCAGCACGCCGTTACCTTTGCCGGCGGTTTGGCTTGCGAAGGGATGAAGCCCGTCGTGGCGATT
TATTCCACCTTTTTACAACGCGCCTACGACCAACTGGTGCACGACATCGCCCTGCAAAACCTGCCCGTTTTGTTTGCCGT
CGACCGCGCGGGCATCGTCGGCGCGGACGGCCCGACCCATGCCGGTTTGTACGATTTAAGCTTTTTGCGCTGCATTCCGA
ATATGATTGTCGCCGCGCCGAGCGATGAAAATGAATGCCGCCTGCTGCTTTCGACCTGCTATCAGGCAGACGCGCCCGCC
GCCGTCCGCTATCCGCGCGGCACGGGTACGGGCGTGCCGGTTTCAGACGGCATGGAAACCGTGGAAATCGGCAAGGGCAT
TATCCGCCGCGAAGGTGAGAAAACCGCCTTCATTGCCTTCGGCAGTATGGTCGCCCCCGCATTGGCGGTTGCCGAAAAAC
TGAACGCCACCGTCGCCGATATGCGCTTTGTCAAACCGATAGACGAAGAGTTGATTGTCCGCCTTGCCCGAAGCCACGAC
CGCATCGTTACCCTTGAAGAAAACGCCGAACAGGGCGGCGCAGGCGGCGCGGTGCTGGAAGTATTGGCGAAACACGGCAT
CTGCAAACCCGTTTTGCTTTTGGGCGTTGCCGATACCGTAACCGGACACGGCGATCCGAAAAAACTTTTAGACGATTTGG
GCTTGAGTGCCGAAGCGGTGGAACGGCGTGTGCGCGCGTGGTTGTCGGATCGGGATGCGGCAAATTAA

Upstream 100 bases:

>100_bases
GCGGCAGGACGAATGACATACGGCAAAATCAGCCGTCAGCCGCACGCTCTTGATATATAATTGGTCGTTGCACCTGGACG
ACACATAAAAAAGACACACC

Downstream 100 bases:

>100_bases
GCCGCCTGGCCGCGCCATCGTCTGCCGATACAAGGCAAAATGCCGTCTGAAACGCTTCAGACGGCATTTTTTCGGCGTAA
GGGTTTAGGCTTCGACAACT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTIALHYVYDTPEDKLVWDVGHQSYP
HKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSSTSIGAALGMAAADKLLGSDRRSVAIIGDGAMTAGQAFEAL
NCAGDMDVDLLVVLNDNEMSISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAE
HAKQSLSLFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVANLPKESAAQMPS
ENKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAI
YSTFLQRAYDQLVHDIALQNLPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPA
AVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVADMRFVKPIDEELIVRLARSHD
RIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN

Sequences:

>Translated_635_residues
MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTIALHYVYDTPEDKLVWDVGHQSYP
HKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSSTSIGAALGMAAADKLLGSDRRSVAIIGDGAMTAGQAFEAL
NCAGDMDVDLLVVLNDNEMSISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAE
HAKQSLSLFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVANLPKESAAQMPS
ENKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAI
YSTFLQRAYDQLVHDIALQNLPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPA
AVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVADMRFVKPIDEELIVRLARSHD
RIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN
>Mature_635_residues
MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTIALHYVYDTPEDKLVWDVGHQSYP
HKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSSTSIGAALGMAAADKLLGSDRRSVAIIGDGAMTAGQAFEAL
NCAGDMDVDLLVVLNDNEMSISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAE
HAKQSLSLFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAENDPVKYHAVANLPKESAAQMPS
ENKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAI
YSTFLQRAYDQLVHDIALQNLPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPA
AVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVADMRFVKPIDEELIVRLARSHD
RIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTVTGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=555, Percent_Identity=24.6846846846847, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4507521, Length=555, Percent_Identity=24.6846846846847, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=520, Percent_Identity=23.6538461538462, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637461, Length=520, Percent_Identity=23.6538461538462, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637459, Length=520, Percent_Identity=23.6538461538462, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI133778974, Length=548, Percent_Identity=23.3576642335766, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=55.591054313099, Blast_Score=704, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=675, Percent_Identity=24.4444444444444, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45551847, Length=567, Percent_Identity=25.7495590828924, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45550715, Length=567, Percent_Identity=25.7495590828924, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24645119, Length=567, Percent_Identity=25.7495590828924, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24666278, Length=299, Percent_Identity=29.0969899665552, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68552; Mature: 68552

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTIALH
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEEE
YVYDTPEDKLVWDVGHQSYPHKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSS
EEEECCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHHCCCHHHCCCCCCC
TSIGAALGMAAADKLLGSDRRSVAIIGDGAMTAGQAFEALNCAGDMDVDLLVVLNDNEMS
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEE
ISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
HAKQSLSLFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAEND
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCC
PVKYHAVANLPKESAAQMPSENKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSG
CEEEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCC
LVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQN
CCHHHHHCCHHHHCCCCCCHHHEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPA
CCEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCC
AVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVAD
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHH
MRFVKPIDEELIVRLARSHDRIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTV
HHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
TGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN
CCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTIALH
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEEE
YVYDTPEDKLVWDVGHQSYPHKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSS
EEEECCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHHCCCHHHCCCCCCC
TSIGAALGMAAADKLLGSDRRSVAIIGDGAMTAGQAFEALNCAGDMDVDLLVVLNDNEMS
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEE
ISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
HAKQSLSLFENFGFRYTGPVDGHNVENLVDVLKDLRSRKGPQLLHVITKKGNGYKLAEND
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCC
PVKYHAVANLPKESAAQMPSENKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSG
CEEEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCC
LVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQN
CCHHHHHCCHHHHCCCCCCHHHEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPA
CCEEEEECCCCEECCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCC
AVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAEKLNATVAD
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCHHHH
MRFVKPIDEELIVRLARSHDRIVTLEENAEQGGAGGAVLEVLAKHGICKPVLLLGVADTV
HHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
TGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN
CCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA