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The map label for this gene is gltA

Identifier: 161723238

GI number: 161723238

Start: 667208

End: 668506

Strand: Direct

Name: gltA

Synonym: L67186

Alternate gene names: 161723238

Gene position: 667208-668506 (Clockwise)

Preceding gene: 15672651

Following gene: 15672653

Centisome position: 28.2

GC content: 32.79

Gene sequence:

>1299_bases
ATGATTAAAAATTCACAAATTCCTAGTGAATTTTACAAAAAGTACAATGTTAAAAAAGGTTTAAGAGACATTAATGGGAA
AGGAGTTTTAGCGGGTTTAACCAATATTTCGGCGATACATTCTTTTGATAAAGAAGGAAACCAAATTCCCGGTATTTTAG
AGTATAGAGCTTATAATATTAAAGATATTATTAATGATTTAAGAAAAGAAAATCGTTTTGGTTTTGAAGAGATGACTTAT
CTATTGTTATTTGGAGAACTTCCCACGGCAAATGAACTTCAGGAATTTCAAAACCTTTTAGCCAGTAGGAGAACTCTACC
AGAATTTTTTATCCGTGAAACTATTTTAACCAACCCTTCAAGTGACGTGATGAATTCGATGAGCCGTTGTATACTAGCTC
TTGCTAGTTACGATGAGAAAGTTTCAGATATCTCGATTGAAAATGTTTTAGAACAATCTTTTGGACTTATTGCTGATTTT
CCACTTCTTGCGATTTACAGTTACCAATCTTATGTTCATTATTTTAAAAAAGAAAGTCTTTATATCCATTATCCTGATCC
AAAAATGACGACCGCTGAGAATATTTTACGAATGCTTCGCCCAGACTGCCATTACACAGAGGTAGAGGCTAAAGTATTAG
ATATTGCCTTGATTCTTCATATGGAACATGGTGGAGGTAACAATTCGACTTTTACGACTCATGTGGTCACCTCAAGTGGA
ACAGATACTTATGCTACAATTGCTGCTGCCCTCTCCAGTTTGAAAGGGCCTAAACACGGTGGAGCTAATATTAAGGCAGC
AAAAATGTTGGAAAATATAAAAGAAAATATTTCTAATTATGAAGATGACGCTGAAATAGAAAAGTATCTCCATAAAATCT
TAAATAAAGAAGTTTTTGATAAGCAAGGATTAATTTATGGTATTGGTCACGCCATTTATAGTTTAAGCGACCCACGATTT
GAGGTTTTTAAATCCTATGTAGAGACTTTAGTAAAAGAAAAAGGATTGGAAGAGGAATTCAAATTATATGAAAAAGTTGC
AAGGCTAGCTCCTAAAGTAATATCGGAAAATCGGAAAATATATAAAACAATTTGTCCAAATGTTGATTTCTACTCTGGCT
TTGTCTATAGAATATTGGAAATTCCACAAGAATTATTTACTCCATTATTTGCGATTGCTAGAATTGTAGGTTGGTTAGCA
CATCGTATAGAAGAACTAATTAATATGAATAAGATTATCCGTCCAGCCTATGAAAGTGTCTTAGAATCAAAAAATTATAT
AAAGTTGGGGGAAAGATGA

Upstream 100 bases:

>100_bases
ATATTTAAATTTTCAGAAAATATATAATTTTCGGAATAAAAAGTGTATAATAATGAAATAGATGGAGGCGTTTATGAATT
TATTGAGTAAAGAAGAAAAA

Downstream 100 bases:

>100_bases
AAAAAATAAGTATTTCTAAAAAAATATACCATTATTATGATATCTCAGAAACTGAAAGAATTGAAGATTTTCCATATAGT
TTACGAGTTCTTTTAGAAAG

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGILEYRAYNIKDIINDLRKENRFGFEEMTY
LLLFGELPTANELQEFQNLLASRRTLPEFFIRETILTNPSSDVMNSMSRCILALASYDEKVSDISIENVLEQSFGLIADF
PLLAIYSYQSYVHYFKKESLYIHYPDPKMTTAENILRMLRPDCHYTEVEAKVLDIALILHMEHGGGNNSTFTTHVVTSSG
TDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISNYEDDAEIEKYLHKILNKEVFDKQGLIYGIGHAIYSLSDPRF
EVFKSYVETLVKEKGLEEEFKLYEKVARLAPKVISENRKIYKTICPNVDFYSGFVYRILEIPQELFTPLFAIARIVGWLA
HRIEELINMNKIIRPAYESVLESKNYIKLGER

Sequences:

>Translated_432_residues
MIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGILEYRAYNIKDIINDLRKENRFGFEEMTY
LLLFGELPTANELQEFQNLLASRRTLPEFFIRETILTNPSSDVMNSMSRCILALASYDEKVSDISIENVLEQSFGLIADF
PLLAIYSYQSYVHYFKKESLYIHYPDPKMTTAENILRMLRPDCHYTEVEAKVLDIALILHMEHGGGNNSTFTTHVVTSSG
TDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISNYEDDAEIEKYLHKILNKEVFDKQGLIYGIGHAIYSLSDPRF
EVFKSYVETLVKEKGLEEEFKLYEKVARLAPKVISENRKIYKTICPNVDFYSGFVYRILEIPQELFTPLFAIARIVGWLA
HRIEELINMNKIIRPAYESVLESKNYIKLGER
>Mature_432_residues
MIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGILEYRAYNIKDIINDLRKENRFGFEEMTY
LLLFGELPTANELQEFQNLLASRRTLPEFFIRETILTNPSSDVMNSMSRCILALASYDEKVSDISIENVLEQSFGLIADF
PLLAIYSYQSYVHYFKKESLYIHYPDPKMTTAENILRMLRPDCHYTEVEAKVLDIALILHMEHGGGNNSTFTTHVVTSSG
TDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISNYEDDAEIEKYLHKILNKEVFDKQGLIYGIGHAIYSLSDPRF
EVFKSYVETLVKEKGLEEEFKLYEKVARLAPKVISENRKIYKTICPNVDFYSGFVYRILEIPQELFTPLFAIARIVGWLA
HRIEELINMNKIIRPAYESVLESKNYIKLGER

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=342, Percent_Identity=28.6549707602339, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786527, Length=407, Percent_Identity=32.1867321867322, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786939, Length=408, Percent_Identity=30.6372549019608, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555174, Length=370, Percent_Identity=27.5675675675676, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=390, Percent_Identity=28.7179487179487, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325257, Length=383, Percent_Identity=29.242819843342, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=364, Percent_Identity=29.3956043956044, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640124, Length=354, Percent_Identity=29.0960451977401, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24640126, Length=354, Percent_Identity=29.0960451977401, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356863, Length=456, Percent_Identity=25, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49454; Mature: 49454

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGILEYRAYNI
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHCCCH
KDIINDLRKENRFGFEEMTYLLLFGELPTANELQEFQNLLASRRTLPEFFIRETILTNPS
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDVMNSMSRCILALASYDEKVSDISIENVLEQSFGLIADFPLLAIYSYQSYVHYFKKESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCE
YIHYPDPKMTTAENILRMLRPDCHYTEVEAKVLDIALILHMEHGGGNNSTFTTHVVTSSG
EEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCC
TDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISNYEDDAEIEKYLHKILNKEVFD
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KQGLIYGIGHAIYSLSDPRFEVFKSYVETLVKEKGLEEEFKLYEKVARLAPKVISENRKI
CCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
YKTICPNVDFYSGFVYRILEIPQELFTPLFAIARIVGWLAHRIEELINMNKIIRPAYESV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESKNYIKLGER
HCCCCCEECCCC
>Mature Secondary Structure
MIKNSQIPSEFYKKYNVKKGLRDINGKGVLAGLTNISAIHSFDKEGNQIPGILEYRAYNI
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHCCCH
KDIINDLRKENRFGFEEMTYLLLFGELPTANELQEFQNLLASRRTLPEFFIRETILTNPS
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDVMNSMSRCILALASYDEKVSDISIENVLEQSFGLIADFPLLAIYSYQSYVHYFKKESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCE
YIHYPDPKMTTAENILRMLRPDCHYTEVEAKVLDIALILHMEHGGGNNSTFTTHVVTSSG
EEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCC
TDTYATIAAALSSLKGPKHGGANIKAAKMLENIKENISNYEDDAEIEKYLHKILNKEVFD
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KQGLIYGIGHAIYSLSDPRFEVFKSYVETLVKEKGLEEEFKLYEKVARLAPKVISENRKI
CCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
YKTICPNVDFYSGFVYRILEIPQELFTPLFAIARIVGWLAHRIEELINMNKIIRPAYESV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LESKNYIKLGER
HCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]