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The map label for this gene is pycA

Identifier: 15672651

GI number: 15672651

Start: 663644

End: 667057

Strand: Direct

Name: pycA

Synonym: L63652

Alternate gene names: 15672651

Gene position: 663644-667057 (Clockwise)

Preceding gene: 15672650

Following gene: 161723238

Centisome position: 28.05

GC content: 38.14

Gene sequence:

>3414_bases
ATGAAAAAACTACTCGTCGCCAATCGTGGAGAAATCGCCGTTCGTGTCTTTCGTGCCTGTAATGAACTCGGACTTTCTAC
TGTAGCCGTCTATGCAAGAGAAGATGAATATTCTGTTCATCGCTTTAAAGCAGATGAATCTTATCTAATCGGTCAAGGAA
AAAAACCAATTGATGCCTATTTGGATATTGATGATATCATTCGTGTTGCCCTTGAATCAGGAGCAGATGCTATTCACCCA
GGTTATGGCCTCTTATCTGAAAATCTCGAATTTGCTACCAAAGTTCGCGCAGCAGGTTTAGTTTTTGTGGGTCCTGAACT
TCATCATTTGGATATTTTCGGTGATAAAATTAAAGCTAAAGCAGCTGCCGACGAAGCAAAAGTTCCAGGAATTCCCGGAA
CAAATGGAGCAGTAGATATCGACGGCGCTTTAGAATTTGCTAAAACTTACGGTTATCCAGTTATGATTAAGGCCGCTTTA
GGCGGTGGTGGTCGCGGAATGCGAGTTGCGAGTAATGATGCTGAAATGCATGATGGTTATGCTAGAGCAAAATCAGAAGC
AATTGGAGCTTTTGGTTCTGGCGAAATCTATGTTGAAAAATATATTGAAAATCCAAAACATATTGAAGTCCAAATTCTTG
GAGATAGTCATGGAAATATTATTCACCTCCATGAGCGTGACTGTTCAGTACAACGACGTAATCAAAAAGTCATTGAAATT
GCGCCAGCCGTGGGACTTTCACTGGACTTCCGTAACGAAATATGTGAAGCAGCAGTCAAACTTTGTAAAAATGTTGGCTA
TGTTAATGCTGGTACAGTTGAGTTTCTTGTTAAAGATGATAAATTTTATTTCATTGAAGTAAATCCACGTGTTCAAGTTG
AACATACAATTACGGAACTTATCACAGGTGTAGATATTGTCCAAGCTCAAATTTTGATTGCTCAAGGTAAAGACTTACAT
AGAGAAATTGGACTTCCAGCACAGTCTGAAATTCCACTTTTGGGTTCAGCAATTCAATGTCGAATCACAACAGAAGATCC
ACAAAATGGATTCTTGCCAGACACAGGTAAAATTGATACTTACCGTTCACCAGGTGGTTTTGGTGTACGTTTAGATGTCG
GAAATGCCTATGCTGGATATGAAGTAACTCCATATTTTGATTCACTTTTAGTAAAAGTTTGTACTTTTGCCAATGAATTT
AGTGACACCGTAAGAAAAATGGACCGCGTTCTCCATGAATTCCGTATTCGTGGTGTCAAAACAAATATTCCTTTCTTGAT
TAATGTTATTGCTAATGAAAACTTCACAAGTGGTCAAGCAACAACAACCTTTATTGATAATACACCAAGTCTGTTCAACT
TCCCACACTTACGTGACCGTGGAACAAAGACGCTGCATTATTTATCAATGATTACAGTCAATGGCTTCCCAGGGATTGAA
AATACTGAAAAACGTCATTTTGAAGAACCACGTCAACCCCTTCTTAATCTTGAAAAGAAAAAGACAGCCAAAAATATCTT
AGATGAACAAGGGGCTGATGCTGTTGTTGATTATGTTAAAAATACAAAAGAAGTATTATTAACAGATACAACTTTACGTG
ATGCTCACCAATCCTTGCTTGCTACTCGCTTACGTTTACAAGATATGAAAGGAATTGCCCAAGCGATTGACCAAGGGCTA
CCAGAACTTTTCTCAGCTGAGATGTGGGGTGGTGCAACCTTTGATGTGGCTTATCGTTTCTTGAATGAATCACCATGGTA
TCGTCTGCGTAAACTACGTAAACTCATGCCAAATACCATGTTCCAAATGCTCTTCCGTGGTTCAAATGCAGTTGGTTACC
AAAACTATCCAGATAATGTGATTGAAGAATTTATCCGAGTAGCGGCGCATGAAGGTATCGATGTTTTCCGTATCTTTGAT
AGTCTTAACTGGTTACCCCAAATGGAAAAATCCATTCAAGCCGTTCGCGATAATGGAAAAATTGCAGAAGCAACAATTTG
TTATACGGGAGATATCCTAGACCCAAGCCGACCAAAATATAATATTCAATACTATAAAGACTTAGCAAAAGAATTAGAAG
CAACAGGTGCTCATATCTTGGCAGTTAAAGATATGGCAGGTTTATTGAAACCTCAAGCTGCTTATCGTTTGATTTCAGAA
TTAAAAGATACCGTTGATTTGCCAATTCATTTGCATACACACGATACTTCAGGAAATGGAATTATTACATATTCTGGTGC
AACTCAAGCAGGTGTAGACATTATTGACGTAGCAACAGCGAGTCTTGCTGGCGGAACATCTCAACCATCAATGCAATCTA
TTTACTATGCACTTGAACATGGTCCTCGCCATGCTTCAATTAATGTAAAAAATGCTGAACAAATTGACCATTATTGGGAA
GATGTTCGTAAATATTATGCACCATTTGAAGCGGGTATTACAAGTCCTCAGACAGAAGTTTACATGCATGAAATGCCTGG
TGGTCAATACACTAACCTAAAATCTCAGGCAGCAGCAGTTGGTCTTGGACATCGTTTTGATGAAATCAAACAAATGTATC
GTAAAGTTAACATGATGTTTGGAGATATTATTAAAGTAACTCCTTCTTCAAAAGTAGTTGGAGATATGGCTCTCTTTATG
ATTCAAAATGATTTAACAGAAGAAGATGTTTATGCGCGTGGTAACGAACTTAATTTCCCAGAATCTGTAGTATCATTCTT
CCGTGGAGATTTAGGACAACCAGTGGGTGGCTTCCCAGAAGAATTACAAAAAATTATCGTGAAAGATAAAGCCGTAATTA
CTGACCGTCCAGGCTTACACGCAGAAAAAGTTGATTTTGAAACTGTTAAAGCAGACCTAGAACAAAAAATTGGCTATGAA
CCAGGAGATCACGAAGTTATCTCATATATCATGTATCCACAAGTTTTCCTTGATTATCAAAAAATGCAAAGAGAATTTGG
AGCAGTTACACTACTTGACACTCCTACTTTCTTACATGGAATGCGTCTCAATGAAAAAATTGAAGTACAAATTGAAAAAG
GTAAAACACTCAGCATTCGTTTAGATGAAATAGGAGAACCTGACCTAGCTGGAAATCGTGTTCTCTTCTTTAACCTAAAT
GGTCAACGTCGAGAAGTCGTAATTAATGACCAATCTGTACAAACTCAAGTTGTGGCTAAACGCAAAGCCGAAACAGGAAA
TCCAAACCAAATTGGAGCTACTATGCCAGGTTCTGTTCTTGAAATTTTAGTTAAAGCTGGTGACAAAGTTCAAAAAGGTC
AAGCCTTGATGGTTACTGAAGCCATGAAAATGGAAACAACTATTGAAGCACCATTTGATGGCGAGATTGTTGACCTTCAT
GTGGTTAAAGGTGAGGCAATTCAAACTCAAGACTTGTTAATCGAAATTAATTAA

Upstream 100 bases:

>100_bases
GTCAGTCGTTTAAAAGTGTATAAAAGATTTTTATAATATATGAAAGAGTGAAAGGTAATGACCAATTACCTTTCCAAGCA
AGCCTCATTAAGGAGTCAAA

Downstream 100 bases:

>100_bases
TATAAATTAAACCTACCTTTTGGGTAGGTTTTTTATTTTTCTTCAAAAAAATATTTAAATTTTCAGAAAATATATAATTT
TCGGAATAAAAAGTGTATAA

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1137; Mature: 1137

Protein sequence:

>1137_residues
MKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYLIGQGKKPIDAYLDIDDIIRVALESGADAIHP
GYGLLSENLEFATKVRAAGLVFVGPELHHLDIFGDKIKAKAAADEAKVPGIPGTNGAVDIDGALEFAKTYGYPVMIKAAL
GGGGRGMRVASNDAEMHDGYARAKSEAIGAFGSGEIYVEKYIENPKHIEVQILGDSHGNIIHLHERDCSVQRRNQKVIEI
APAVGLSLDFRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITELITGVDIVQAQILIAQGKDLH
REIGLPAQSEIPLLGSAIQCRITTEDPQNGFLPDTGKIDTYRSPGGFGVRLDVGNAYAGYEVTPYFDSLLVKVCTFANEF
SDTVRKMDRVLHEFRIRGVKTNIPFLINVIANENFTSGQATTTFIDNTPSLFNFPHLRDRGTKTLHYLSMITVNGFPGIE
NTEKRHFEEPRQPLLNLEKKKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLLATRLRLQDMKGIAQAIDQGL
PELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNTMFQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFD
SLNWLPQMEKSIQAVRDNGKIAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHILAVKDMAGLLKPQAAYRLISE
LKDTVDLPIHLHTHDTSGNGIITYSGATQAGVDIIDVATASLAGGTSQPSMQSIYYALEHGPRHASINVKNAEQIDHYWE
DVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAVGLGHRFDEIKQMYRKVNMMFGDIIKVTPSSKVVGDMALFM
IQNDLTEEDVYARGNELNFPESVVSFFRGDLGQPVGGFPEELQKIIVKDKAVITDRPGLHAEKVDFETVKADLEQKIGYE
PGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLHGMRLNEKIEVQIEKGKTLSIRLDEIGEPDLAGNRVLFFNLN
GQRREVVINDQSVQTQVVAKRKAETGNPNQIGATMPGSVLEILVKAGDKVQKGQALMVTEAMKMETTIEAPFDGEIVDLH
VVKGEAIQTQDLLIEIN

Sequences:

>Translated_1137_residues
MKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYLIGQGKKPIDAYLDIDDIIRVALESGADAIHP
GYGLLSENLEFATKVRAAGLVFVGPELHHLDIFGDKIKAKAAADEAKVPGIPGTNGAVDIDGALEFAKTYGYPVMIKAAL
GGGGRGMRVASNDAEMHDGYARAKSEAIGAFGSGEIYVEKYIENPKHIEVQILGDSHGNIIHLHERDCSVQRRNQKVIEI
APAVGLSLDFRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITELITGVDIVQAQILIAQGKDLH
REIGLPAQSEIPLLGSAIQCRITTEDPQNGFLPDTGKIDTYRSPGGFGVRLDVGNAYAGYEVTPYFDSLLVKVCTFANEF
SDTVRKMDRVLHEFRIRGVKTNIPFLINVIANENFTSGQATTTFIDNTPSLFNFPHLRDRGTKTLHYLSMITVNGFPGIE
NTEKRHFEEPRQPLLNLEKKKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLLATRLRLQDMKGIAQAIDQGL
PELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNTMFQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFD
SLNWLPQMEKSIQAVRDNGKIAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHILAVKDMAGLLKPQAAYRLISE
LKDTVDLPIHLHTHDTSGNGIITYSGATQAGVDIIDVATASLAGGTSQPSMQSIYYALEHGPRHASINVKNAEQIDHYWE
DVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAVGLGHRFDEIKQMYRKVNMMFGDIIKVTPSSKVVGDMALFM
IQNDLTEEDVYARGNELNFPESVVSFFRGDLGQPVGGFPEELQKIIVKDKAVITDRPGLHAEKVDFETVKADLEQKIGYE
PGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLHGMRLNEKIEVQIEKGKTLSIRLDEIGEPDLAGNRVLFFNLN
GQRREVVINDQSVQTQVVAKRKAETGNPNQIGATMPGSVLEILVKAGDKVQKGQALMVTEAMKMETTIEAPFDGEIVDLH
VVKGEAIQTQDLLIEIN
>Mature_1137_residues
MKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYLIGQGKKPIDAYLDIDDIIRVALESGADAIHP
GYGLLSENLEFATKVRAAGLVFVGPELHHLDIFGDKIKAKAAADEAKVPGIPGTNGAVDIDGALEFAKTYGYPVMIKAAL
GGGGRGMRVASNDAEMHDGYARAKSEAIGAFGSGEIYVEKYIENPKHIEVQILGDSHGNIIHLHERDCSVQRRNQKVIEI
APAVGLSLDFRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITELITGVDIVQAQILIAQGKDLH
REIGLPAQSEIPLLGSAIQCRITTEDPQNGFLPDTGKIDTYRSPGGFGVRLDVGNAYAGYEVTPYFDSLLVKVCTFANEF
SDTVRKMDRVLHEFRIRGVKTNIPFLINVIANENFTSGQATTTFIDNTPSLFNFPHLRDRGTKTLHYLSMITVNGFPGIE
NTEKRHFEEPRQPLLNLEKKKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLLATRLRLQDMKGIAQAIDQGL
PELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNTMFQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFD
SLNWLPQMEKSIQAVRDNGKIAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHILAVKDMAGLLKPQAAYRLISE
LKDTVDLPIHLHTHDTSGNGIITYSGATQAGVDIIDVATASLAGGTSQPSMQSIYYALEHGPRHASINVKNAEQIDHYWE
DVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAVGLGHRFDEIKQMYRKVNMMFGDIIKVTPSSKVVGDMALFM
IQNDLTEEDVYARGNELNFPESVVSFFRGDLGQPVGGFPEELQKIIVKDKAVITDRPGLHAEKVDFETVKADLEQKIGYE
PGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLHGMRLNEKIEVQIEKGKTLSIRLDEIGEPDLAGNRVLFFNLN
GQRREVVINDQSVQTQVVAKRKAETGNPNQIGATMPGSVLEILVKAGDKVQKGQALMVTEAMKMETTIEAPFDGEIVDLH
VVKGEAIQTQDLLIEIN

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1143, Percent_Identity=49.1688538932633, Blast_Score=1081, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1143, Percent_Identity=49.1688538932633, Blast_Score=1081, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1143, Percent_Identity=49.1688538932633, Blast_Score=1081, Evalue=0.0,
Organism=Homo sapiens, GI189095269, Length=499, Percent_Identity=42.685370741483, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI65506442, Length=499, Percent_Identity=42.685370741483, Blast_Score=375, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=499, Percent_Identity=42.685370741483, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI116805327, Length=449, Percent_Identity=42.9844097995546, Blast_Score=350, Evalue=3e-96,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=30.952380952381, Blast_Score=228, Evalue=4e-59,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=30.952380952381, Blast_Score=227, Evalue=4e-59,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=30.952380952381, Blast_Score=227, Evalue=4e-59,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=30.952380952381, Blast_Score=227, Evalue=4e-59,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=30.952380952381, Blast_Score=227, Evalue=5e-59,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=30.6930693069307, Blast_Score=226, Evalue=8e-59,
Organism=Escherichia coli, GI1789654, Length=453, Percent_Identity=45.6953642384106, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1786216, Length=313, Percent_Identity=22.3642172523962, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562816, Length=1142, Percent_Identity=49.4746059544659, Blast_Score=1101, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=44.4196428571429, Blast_Score=359, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI71987519, Length=541, Percent_Identity=40.6654343807763, Blast_Score=358, Evalue=7e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.8568507157464, Blast_Score=211, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=438, Percent_Identity=29.9086757990868, Blast_Score=202, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=438, Percent_Identity=29.9086757990868, Blast_Score=202, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1151, Percent_Identity=48.1320590790617, Blast_Score=1075, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1151, Percent_Identity=48.4795829713293, Blast_Score=1062, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=36.5470852017937, Blast_Score=286, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323863, Length=436, Percent_Identity=36.0091743119266, Blast_Score=239, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=32.4902723735409, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24652212, Length=1146, Percent_Identity=49.3019197207679, Blast_Score=1104, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1146, Percent_Identity=49.3019197207679, Blast_Score=1104, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1146, Percent_Identity=49.3019197207679, Blast_Score=1104, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1146, Percent_Identity=49.3019197207679, Blast_Score=1104, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1146, Percent_Identity=49.3019197207679, Blast_Score=1104, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1162, Percent_Identity=48.6230636833046, Blast_Score=1098, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1162, Percent_Identity=48.6230636833046, Blast_Score=1098, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1162, Percent_Identity=48.6230636833046, Blast_Score=1098, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1162, Percent_Identity=48.6230636833046, Blast_Score=1098, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1162, Percent_Identity=48.6230636833046, Blast_Score=1098, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=450, Percent_Identity=42.6666666666667, Blast_Score=345, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24651759, Length=412, Percent_Identity=41.747572815534, Blast_Score=305, Evalue=1e-82,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=30, Blast_Score=213, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=30, Blast_Score=213, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=30, Blast_Score=213, Evalue=7e-55,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=30, Blast_Score=213, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 126408; Mature: 126408

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYLIGQGKKPIDAY
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCEEECCCCCCHHHH
LDIDDIIRVALESGADAIHPGYGLLSENLEFATKVRAAGLVFVGPELHHLDIFGDKIKAK
CCHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHCCEEEECCCEEEEEEECCHHHHH
AAADEAKVPGIPGTNGAVDIDGALEFAKTYGYPVMIKAALGGGGRGMRVASNDAEMHDGY
HCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHCHH
ARAKSEAIGAFGSGEIYVEKYIENPKHIEVQILGDSHGNIIHLHERDCSVQRRNQKVIEI
HHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCHHHCCCEEEEE
APAVGLSLDFRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITEL
ECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCEEEHHHHHHH
ITGVDIVQAQILIAQGKDLHREIGLPAQSEIPLLGSAIQCRITTEDPQNGFLPDTGKIDT
HHCHHHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
YRSPGGFGVRLDVGNAYAGYEVTPYFDSLLVKVCTFANEFSDTVRKMDRVLHEFRIRGVK
CCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
TNIPFLINVIANENFTSGQATTTFIDNTPSLFNFPHLRDRGTKTLHYLSMITVNGFPGIE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCC
NTEKRHFEEPRQPLLNLEKKKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLL
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHH
ATRLRLQDMKGIAQAIDQGLPELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNTM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFDSLNWLPQMEKSIQAVRDNGK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
IAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHILAVKDMAGLLKPQAAYRLISE
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHCHHHHHHHHHH
LKDTVDLPIHLHTHDTSGNGIITYSGATQAGVDIIDVATASLAGGTSQPSMQSIYYALEH
HHHHCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHHHHHC
GPRHASINVKNAEQIDHYWEDVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAV
CCCEEEEECCCHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
GLGHRFDEIKQMYRKVNMMFGDIIKVTPSSKVVGDMALFMIQNDLTEEDVYARGNELNFP
HCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCH
ESVVSFFRGDLGQPVGGFPEELQKIIVKDKAVITDRPGLHAEKVDFETVKADLEQKIGYE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
PGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLHGMRLNEKIEVQIEKGKTLSIR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCEEEEEEECCCEEEEE
LDEIGEPDLAGNRVLFFNLNGQRREVVINDQSVQTQVVAKRKAETGNPNQIGATMPGSVL
ECCCCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
EILVKAGDKVQKGQALMVTEAMKMETTIEAPFDGEIVDLHVVKGEAIQTQDLLIEIN
HHHHHCCCCCCCCCEEEEEHHHHHCEEECCCCCCCEEEEEEECCCCEEEEEEEEEEC
>Mature Secondary Structure
MKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYLIGQGKKPIDAY
CCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCEEECCCCCCHHHH
LDIDDIIRVALESGADAIHPGYGLLSENLEFATKVRAAGLVFVGPELHHLDIFGDKIKAK
CCHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHCCEEEECCCEEEEEEECCHHHHH
AAADEAKVPGIPGTNGAVDIDGALEFAKTYGYPVMIKAALGGGGRGMRVASNDAEMHDGY
HCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHCHH
ARAKSEAIGAFGSGEIYVEKYIENPKHIEVQILGDSHGNIIHLHERDCSVQRRNQKVIEI
HHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEECCCCCHHHCCCEEEEE
APAVGLSLDFRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITEL
ECCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCCEEEHHHHHHH
ITGVDIVQAQILIAQGKDLHREIGLPAQSEIPLLGSAIQCRITTEDPQNGFLPDTGKIDT
HHCHHHHHHEEEEECCCHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
YRSPGGFGVRLDVGNAYAGYEVTPYFDSLLVKVCTFANEFSDTVRKMDRVLHEFRIRGVK
CCCCCCEEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
TNIPFLINVIANENFTSGQATTTFIDNTPSLFNFPHLRDRGTKTLHYLSMITVNGFPGIE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCC
NTEKRHFEEPRQPLLNLEKKKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLL
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECCHHHHHHHHHH
ATRLRLQDMKGIAQAIDQGLPELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNTM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFDSLNWLPQMEKSIQAVRDNGK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
IAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHILAVKDMAGLLKPQAAYRLISE
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHCHHHHHHHHHH
LKDTVDLPIHLHTHDTSGNGIITYSGATQAGVDIIDVATASLAGGTSQPSMQSIYYALEH
HHHHCCCEEEEEEECCCCCEEEEECCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHHHHHC
GPRHASINVKNAEQIDHYWEDVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAV
CCCEEEEECCCHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
GLGHRFDEIKQMYRKVNMMFGDIIKVTPSSKVVGDMALFMIQNDLTEEDVYARGNELNFP
HCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCH
ESVVSFFRGDLGQPVGGFPEELQKIIVKDKAVITDRPGLHAEKVDFETVKADLEQKIGYE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCC
PGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLHGMRLNEKIEVQIEKGKTLSIR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCEEEEEEECCCEEEEE
LDEIGEPDLAGNRVLFFNLNGQRREVVINDQSVQTQVVAKRKAETGNPNQIGATMPGSVL
ECCCCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
EILVKAGDKVQKGQALMVTEAMKMETTIEAPFDGEIVDLHVVKGEAIQTQDLLIEIN
HHHHHCCCCCCCCCEEEEEHHHHHCEEECCCCCCCEEEEEEECCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]