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The map label for this gene is cynR [H]

Identifier: 161723134

GI number: 161723134

Start: 1346675

End: 1347610

Strand: Direct

Name: cynR [H]

Synonym: BTH_I1200

Alternate gene names: 161723134

Gene position: 1346675-1347610 (Clockwise)

Preceding gene: 83720633

Following gene: 83718519

Centisome position: 35.35

GC content: 68.06

Gene sequence:

>936_bases
ATGCTGCTCCGACACATCCGCTATTTTCTCGCCGTCGCCGAGCAGGGCAACTTCACGCGCGCGGCCGAATCGTTGCACGT
GTCCCAACCGACACTGTCGCAGCAGATCCGGCAACTCGAGGGCGCGCTCGGCGTGCAACTGTTCGACCGCTCGGCTCGCG
CGGTGCGATTGACCGAATTCGGCGCCGCGTACGCGCGGCACGCGCGCGCCGCGTTGCAGCAGCTCGAGGCCGGGCGGCGC
GCGGTGCACGACGTCGAGAATCTGCAAAGCGGCTCGTTGCGGCTCGCGATGACGCCGACTTTCTCCGCGTATCTGATCGG
CTGGTTGATCGACGGCTTCAACGCGCGCTATCCGAACCTGAAGCTGACGATCCGCGAGATGCCGCAGGAGCAGATCGAGC
CGCTTCTCGCCGACGACGAGCTCGACGTCGGGATCGCGTTCGATGCGATGCAGTCGCCGGAAATCGAAGCGACGCCGCTC
TGGGTCGAGACGCTTGCACTCGTTGTGGGCCGCGGCCATCGCCACGCGCGTCGACGCAAGCCGCTTTCGCCCGAGGCGGC
CGCCGACGAGCCGCTGATCCTGTTGAGCCGCGCATTCGCGACGCGCAGCAAGGTCGACGAGTACTTCCGCAGCAACGGCG
TGACGCCGCACGTCGCGATCGAGGTGAACTCGATCAGCACGATGCTCGAGATGGTGCGCGGCGGACGGGTTGCGACGGTG
CTGCCGTCGGCGATCGCCGAGCGTCGCGACGACTTGTGCGCGATCCGGCTCGAACCGCCGCTACCGCACCGCACGGCCGC
GCTGTTGATGCGCAAGGGCGGGTATCGAAGCGCGGCGATGCGGGCGTTCGTCGATCACGTGCTGGCGAGGCGGCACGAAA
TCGGAAATCGCGGCGGGGCGAGGGCGCGAGGCAGTATGCCGTCGAGCGGCGAGTAG

Upstream 100 bases:

>100_bases
GGCGGCGAGAGCCGACGACCGAAGAATGAGGCAAACGATTCATAGCGTCCAAGACCGGTTTATTATTGTTCGCATAGGCA
ACGCCAATATCTTGGACACG

Downstream 100 bases:

>100_bases
CCGCGAGGCGCGAGGCGGTCCGCGCCGCGGTGCGCGATCGTCCCGGCGGCGCACGACGTTCGGCGCTAGGCGGGGCGGCG
TCGACGCGCGCGGCGCATGT

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGALGVQLFDRSARAVRLTEFGAAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDAMQSPEIEATPL
WVETLALVVGRGHRHARRRKPLSPEAAADEPLILLSRAFATRSKVDEYFRSNGVTPHVAIEVNSISTMLEMVRGGRVATV
LPSAIAERRDDLCAIRLEPPLPHRTAALLMRKGGYRSAAMRAFVDHVLARRHEIGNRGGARARGSMPSSGE

Sequences:

>Translated_311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGALGVQLFDRSARAVRLTEFGAAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDAMQSPEIEATPL
WVETLALVVGRGHRHARRRKPLSPEAAADEPLILLSRAFATRSKVDEYFRSNGVTPHVAIEVNSISTMLEMVRGGRVATV
LPSAIAERRDDLCAIRLEPPLPHRTAALLMRKGGYRSAAMRAFVDHVLARRHEIGNRGGARARGSMPSSGE
>Mature_311_residues
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGALGVQLFDRSARAVRLTEFGAAYARHARAALQQLEAGRR
AVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNLKLTIREMPQEQIEPLLADDELDVGIAFDAMQSPEIEATPL
WVETLALVVGRGHRHARRRKPLSPEAAADEPLILLSRAFATRSKVDEYFRSNGVTPHVAIEVNSISTMLEMVRGGRVATV
LPSAIAERRDDLCAIRLEPPLPHRTAALLMRKGGYRSAAMRAFVDHVLARRHEIGNRGGARARGSMPSSGE

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=295, Percent_Identity=54.2372881355932, Blast_Score=304, Evalue=4e-84,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=30.6859205776173, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788297, Length=254, Percent_Identity=31.8897637795276, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=30.4054054054054, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787530, Length=291, Percent_Identity=28.8659793814433, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693105, Length=293, Percent_Identity=26.6211604095563, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1788748, Length=286, Percent_Identity=26.5734265734266, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787879, Length=296, Percent_Identity=30.4054054054054, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789204, Length=236, Percent_Identity=31.3559322033898, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87081904, Length=255, Percent_Identity=29.8039215686275, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI2367136, Length=246, Percent_Identity=30.8943089430894, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788481, Length=293, Percent_Identity=29.3515358361775, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788296, Length=206, Percent_Identity=30.0970873786408, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789173, Length=240, Percent_Identity=31.25, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786401, Length=154, Percent_Identity=33.7662337662338, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787601, Length=243, Percent_Identity=26.3374485596708, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=251, Percent_Identity=24.7011952191235, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082132, Length=295, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=28.4, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=150, Percent_Identity=31.3333333333333, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786713, Length=185, Percent_Identity=29.7297297297297, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34438; Mature: 34438

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGALGVQLFDRSARAVRLTEF
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHH
GAAYARHARAALQQLEAGRRAVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCE
KLTIREMPQEQIEPLLADDELDVGIAFDAMQSPEIEATPLWVETLALVVGRGHRHARRRK
EEEHHHCCHHHCCCHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
PLSPEAAADEPLILLSRAFATRSKVDEYFRSNGVTPHVAIEVNSISTMLEMVRGGRVATV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCEEHH
LPSAIAERRDDLCAIRLEPPLPHRTAALLMRKGGYRSAAMRAFVDHVLARRHEIGNRGGA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RARGSMPSSGE
CCCCCCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAESLHVSQPTLSQQIRQLEGALGVQLFDRSARAVRLTEF
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHH
GAAYARHARAALQQLEAGRRAVHDVENLQSGSLRLAMTPTFSAYLIGWLIDGFNARYPNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCE
KLTIREMPQEQIEPLLADDELDVGIAFDAMQSPEIEATPLWVETLALVVGRGHRHARRRK
EEEHHHCCHHHCCCHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
PLSPEAAADEPLILLSRAFATRSKVDEYFRSNGVTPHVAIEVNSISTMLEMVRGGRVATV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCEEHH
LPSAIAERRDDLCAIRLEPPLPHRTAALLMRKGGYRSAAMRAFVDHVLARRHEIGNRGGA
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
RARGSMPSSGE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]