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The map label for this gene is atpA

Identifier: 161621777

GI number: 161621777

Start: 1531767

End: 1533278

Strand: Direct

Name: atpA

Synonym: LIC11241

Alternate gene names: 161621777

Gene position: 1531767-1533278 (Clockwise)

Preceding gene: 45657123

Following gene: 45657125

Centisome position: 35.81

GC content: 44.91

Gene sequence:

>1512_bases
ATGAAAATTAAAACAGACGAAATTACGTCCGTTCTCAAGCAGGAAATTTTAAATTATAAAAAAGATCTGGGCGTGGAAGA
AGTCGGAACGGTCCTCGAGATCGGAGACGGAATCGCTCGTGTATTTGGACTTAAAAACGTGATGTCCGGGGAGATGGTGG
AATTCCAAAACGGAATCTTTGGTCAGGCATTCAACCTCGAAGACAACTCCGTAGGTGTGGTAGTTTATGGAAACTACCTG
GATATTCAGGAAGGATTTTCCGTTAAAAGAACAAATCGAATTCTTGAAGTGCCCGTAGGTCCTGAACTTCTCGGTCGCGT
AGTGAATCCGTTAGGTGAACCCATCGACGGAAAAGGTCCGATCAACGCAAAACTTACCAGACCTGTGGAATCCCCCGCTC
CTGGAATTGCTATGAGACAACCCGTAGGTGAGCCGATGCAAACCGGAATCAAAGCAATCGACGCAATGATCCCGATAGGA
CGCGGACAAAGAGAGTTAATTATCGGAGATCGTGGAACCGGTAAAACTTCTATTGCACTGGATACTATTCTCAACCAAAA
AGGAACGGGTGTTATCTGCGTCTATGTAGCGATCGGTCAAAAGGCTTCTACAGTGGCTTCTACGGTAGAGATGCTTCGTA
ACAAAGGTGCTCTTGAATATACGATCGTAGTTTCCGCTACCGCCGCGGACCCGGCTCCTCTGCAATACATTGCTCCTTAT
TCCGGATGTAGTATGGCAGAATATTTTATGTATAACGAAAAGAAAGCGACTCTTGTAGTTTACGATGACCTTTCTAAACA
AGCGGTTGCATATCGTCAGATGTCTCTTCTGCTTCGTCGCCCTCCTGGTCGGGAAGCATATCCTGGAGACGTATTTTATC
TTCACTCCAGACTTCTTGAAAGAGCAGCTAAACTGGATGACAAATATGGTGCGGGTTCTTTGACCGCGCTTCCGATCATC
GAGACTCAAGAAGGTGAGGTTTCGGCTTATATTCCAACGAACGTGATTTCGATCACGGACGGACAGATTTATCTTCAGTC
TAACTTGTTTGCATCTGGGAATCGTCCTGCGGTAGATGTGGGAATTTCGGTTTCTCGAGTAGGATCCGCTGCACAGATCA
AAGCGATGAAACAAGTCGCCGGTAAGATGAAATTAGAACTCGCACAGTTCCGTGACCTCGAAGCATTTGCTCAACTCGGA
ACCGAATTGGATCCTGCTACACAGGCGCAGTTGGATCGTGGAAATAGAATTGTTCAGATGCTCAAACAGCCAGTTTCTTC
TCCTTATCCGGTCGAAGAACAAGTAGTGGAAATTTTTGCGGTAACTCGCGGATTTATGGATAAGATTCCAGTAGCAAAAG
TTCAAGAATACGGAAAATATCTTTTGAATACGATCAAGGAACAATATTCCGAAGTTCTGGATTCGATCCGCAAAGAAAAG
AAAATCTCCGACGAAGAAAAACTTGGAGAAGTTCTTTCTAAGGTCGCGGAAGAATTTTTAAGAAAGCACTGA

Upstream 100 bases:

>100_bases
GTACAATTCAATGACTTAAAAATCGAAAAGTCAATCGCTTCCCAGCTGGGGGAAATCAAGAAGTCCATGCTGGAAAAGAA
ATTACCGGTTGGAGCCATCT

Downstream 100 bases:

>100_bases
GATAGAGGTTCGCTTTGGCAACTCCCAGAGAAATCAAAAAAAGAATCAACTCGGTAAAGAATACTAGAAAGATCACTCGT
ACGATGGAAATGGTTTCTAC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKIKTDEITSVLKQEILNYKKDLGVEEVGTVLEIGDGIARVFGLKNVMSGEMVEFQNGIFGQAFNLEDNSVGVVVYGNYL
DIQEGFSVKRTNRILEVPVGPELLGRVVNPLGEPIDGKGPINAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIALDTILNQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAADPAPLQYIAPY
SGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKYGAGSLTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDVGISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLG
TELDPATQAQLDRGNRIVQMLKQPVSSPYPVEEQVVEIFAVTRGFMDKIPVAKVQEYGKYLLNTIKEQYSEVLDSIRKEK
KISDEEKLGEVLSKVAEEFLRKH

Sequences:

>Translated_503_residues
MKIKTDEITSVLKQEILNYKKDLGVEEVGTVLEIGDGIARVFGLKNVMSGEMVEFQNGIFGQAFNLEDNSVGVVVYGNYL
DIQEGFSVKRTNRILEVPVGPELLGRVVNPLGEPIDGKGPINAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIALDTILNQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAADPAPLQYIAPY
SGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKYGAGSLTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDVGISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLG
TELDPATQAQLDRGNRIVQMLKQPVSSPYPVEEQVVEIFAVTRGFMDKIPVAKVQEYGKYLLNTIKEQYSEVLDSIRKEK
KISDEEKLGEVLSKVAEEFLRKH
>Mature_503_residues
MKIKTDEITSVLKQEILNYKKDLGVEEVGTVLEIGDGIARVFGLKNVMSGEMVEFQNGIFGQAFNLEDNSVGVVVYGNYL
DIQEGFSVKRTNRILEVPVGPELLGRVVNPLGEPIDGKGPINAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIG
RGQRELIIGDRGTGKTSIALDTILNQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAADPAPLQYIAPY
SGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKYGAGSLTALPII
ETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDVGISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLG
TELDPATQAQLDRGNRIVQMLKQPVSSPYPVEEQVVEIFAVTRGFMDKIPVAKVQEYGKYLLNTIKEQYSEVLDSIRKEK
KISDEEKLGEVLSKVAEEFLRKH

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=508, Percent_Identity=61.2204724409449, Blast_Score=607, Evalue=1e-174,
Organism=Homo sapiens, GI4757810, Length=508, Percent_Identity=61.2204724409449, Blast_Score=607, Evalue=1e-174,
Organism=Homo sapiens, GI19913428, Length=305, Percent_Identity=29.8360655737705, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI19913426, Length=306, Percent_Identity=28.7581699346405, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI32189394, Length=397, Percent_Identity=25.6926952141058, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1790172, Length=496, Percent_Identity=52.8225806451613, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1788251, Length=319, Percent_Identity=29.153605015674, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790170, Length=350, Percent_Identity=25.4285714285714, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988063, Length=486, Percent_Identity=60.9053497942387, Blast_Score=583, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71988080, Length=486, Percent_Identity=60.9053497942387, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI71988074, Length=486, Percent_Identity=56.7901234567901, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17510931, Length=366, Percent_Identity=28.6885245901639, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=323, Percent_Identity=29.7213622291022, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144756, Length=390, Percent_Identity=25.8974358974359, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988068, Length=72, Percent_Identity=54.1666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509265, Length=51, Percent_Identity=60.7843137254902, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=492, Percent_Identity=57.520325203252, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6322581, Length=424, Percent_Identity=26.6509433962264, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=299, Percent_Identity=29.7658862876254, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658560, Length=506, Percent_Identity=59.2885375494071, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI281361666, Length=294, Percent_Identity=29.9319727891156, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646341, Length=294, Percent_Identity=29.9319727891156, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136796, Length=294, Percent_Identity=29.9319727891156, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24638766, Length=439, Percent_Identity=25.5125284738041, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574560, Length=412, Percent_Identity=25.7281553398058, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24583988, Length=412, Percent_Identity=23.0582524271845, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583986, Length=412, Percent_Identity=23.0582524271845, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583984, Length=412, Percent_Identity=23.0582524271845, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583992, Length=402, Percent_Identity=23.8805970149254, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55014; Mature: 55014

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTDEITSVLKQEILNYKKDLGVEEVGTVLEIGDGIARVFGLKNVMSGEMVEFQNGIF
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
GQAFNLEDNSVGVVVYGNYLDIQEGFSVKRTNRILEVPVGPELLGRVVNPLGEPIDGKGP
CEEECCCCCCEEEEEECCEEECCCCCCEECCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
INAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIAL
CCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHH
DTILNQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAADPAPLQYIAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEECCC
SGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCHHHHHEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLDDKYGAGSLTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEECEEECCCCCEEEE
GISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLGTELDPATQAQLDRGNRIVQM
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHH
LKQPVSSPYPVEEQVVEIFAVTRGFMDKIPVAKVQEYGKYLLNTIKEQYSEVLDSIRKEK
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KISDEEKLGEVLSKVAEEFLRKH
CCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIKTDEITSVLKQEILNYKKDLGVEEVGTVLEIGDGIARVFGLKNVMSGEMVEFQNGIF
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
GQAFNLEDNSVGVVVYGNYLDIQEGFSVKRTNRILEVPVGPELLGRVVNPLGEPIDGKGP
CEEECCCCCCEEEEEECCEEECCCCCCEECCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
INAKLTRPVESPAPGIAMRQPVGEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIAL
CCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHH
DTILNQKGTGVICVYVAIGQKASTVASTVEMLRNKGALEYTIVVSATAADPAPLQYIAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEECCC
SGCSMAEYFMYNEKKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCHHHHHEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAAKLDDKYGAGSLTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGNRPAVDV
HHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEECEEECCCCCEEEE
GISVSRVGSAAQIKAMKQVAGKMKLELAQFRDLEAFAQLGTELDPATQAQLDRGNRIVQM
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHH
LKQPVSSPYPVEEQVVEIFAVTRGFMDKIPVAKVQEYGKYLLNTIKEQYSEVLDSIRKEK
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KISDEEKLGEVLSKVAEEFLRKH
CCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA