Click here to switch to the map view.

The map label for this gene is trpB

Identifier: 161594051

GI number: 161594051

Start: 2998003

End: 2999205

Strand: Reverse

Name: trpB

Synonym: CV_2762

Alternate gene names: 161594051

Gene position: 2999205-2998003 (Counterclockwise)

Preceding gene: 34498218

Following gene: 34498216

Centisome position: 63.13

GC content: 65.59

Gene sequence:

>1203_bases
ATGGATCGGTATGATTTTCCGGATGCGCAGGGCCATTTCGGCCCTTACGGCGGGGTCTACGTCGCCGAAACCTTGATGGT
GGCGCTGGACCAGCTGAAAGAAGAGTACGCCCGAGTGAAGGCCGATCCGACGTTCTGGCAGGAGTTCCATCATGAACTCA
AGCACTATGTCGGCCGGCCCAGCCCGGTCTACCATGCCAAGCGCTGGTCCGAGCAGCTGGGCGGCGCGCAGATCTGGTTC
AAGCGCGAAGACCTGAACCACACCGGCGCCCACAAGATCAACAACGCCATCGGCCAGGCGCTGCTGGCCCGCCGCATGGG
CAAGAAGCGGGTGATCGCCGAGACCGGCGCCGGCCAGCACGGCGTGGCCACCGCCACCGTCGCCGCGCGCTACGGCATGG
AGTGCGTGGTGTACATGGGCGCGGAAGACGTGAAGCGCCAGTCGCCGAATGTGTTCCGCATGAAGCTCCTGGGCGCCACC
GTGGTGCCGGTGGAGTCCGGCTCCAAGACGCTGAAGGACGCGCTGAACGAAGCGATGCGCGACTGGGTGACGAATGTCGA
TTCCACCTTCTACATTCTCGGCACCGCCGCCGGCCCGCATCCTTATCCGATGCTGGTGCGCGATTTCGTATCGGTGATCG
GCGCGGAATCCAAGATCCAGATGCCGGAAGCGATAGGCCGCCAGCCCGATGTGGTGGTGGCTTGCGTGGGCGGCGGCTCC
AACGCGATCGGCATGTTCCATCCTTACATCGAGGTGCCGGGCGTGCGCATGGTGGGCGTGGAGGCGGGCGGCCACGGCGT
CGCCAGCGGCAAGCACGCCGCGCCGATTTCCTCCGGCGCGCCGGTGGGTGTGCTGCACGGCTCCAAGAGTTATCTGATGC
AGGACGCGGACGGCCAGATCGTGGAGACCCACTCGGTGTCCGCAGGCCTCGATTACCCCGGCGTGGGGCCCGAGCACTGC
CATCTGAAGGACATCGGCCGCGCGGAATACGTGTCGATCGACGATGACGAAGCGCTGCGCGCTTTCCACGACTGCTGTCA
TCTGGAAGGCATCATCCCGGCGCTGGAGTCCAGCCACGCGCTGGCCTGGGCCGCCAAGGTGGCGCCGAGCATGGGCAAGG
ATCAGGTGATCCTGGTCAATCTGTCCGGCCGCGGCGACAAGGACATCAATACCGTTGCCGGCTTGGCCGGCATCACGCTG
TGA

Upstream 100 bases:

>100_bases
CGGGTGAGGCCGGCCGCGGTTGACGTCTCCAGCGGAGTGGAGGCGGGCAAGGGAATCAAAGACGCCGCCAGGATGGCGGC
CTTCATATCAGGAGCAAGAC

Downstream 100 bases:

>100_bases
AGGGGGCGAGAATGTCACGCATTGCTAACTGTTTTGCCGAGCTCGCGGGCAAGAAAGCCCTGATCCCGTTCATCACCGCC
GGCGATCCGCATCCTGGCTT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MDRYDFPDAQGHFGPYGGVYVAETLMVALDQLKEEYARVKADPTFWQEFHHELKHYVGRPSPVYHAKRWSEQLGGAQIWF
KREDLNHTGAHKINNAIGQALLARRMGKKRVIAETGAGQHGVATATVAARYGMECVVYMGAEDVKRQSPNVFRMKLLGAT
VVPVESGSKTLKDALNEAMRDWVTNVDSTFYILGTAAGPHPYPMLVRDFVSVIGAESKIQMPEAIGRQPDVVVACVGGGS
NAIGMFHPYIEVPGVRMVGVEAGGHGVASGKHAAPISSGAPVGVLHGSKSYLMQDADGQIVETHSVSAGLDYPGVGPEHC
HLKDIGRAEYVSIDDDEALRAFHDCCHLEGIIPALESSHALAWAAKVAPSMGKDQVILVNLSGRGDKDINTVAGLAGITL

Sequences:

>Translated_400_residues
MDRYDFPDAQGHFGPYGGVYVAETLMVALDQLKEEYARVKADPTFWQEFHHELKHYVGRPSPVYHAKRWSEQLGGAQIWF
KREDLNHTGAHKINNAIGQALLARRMGKKRVIAETGAGQHGVATATVAARYGMECVVYMGAEDVKRQSPNVFRMKLLGAT
VVPVESGSKTLKDALNEAMRDWVTNVDSTFYILGTAAGPHPYPMLVRDFVSVIGAESKIQMPEAIGRQPDVVVACVGGGS
NAIGMFHPYIEVPGVRMVGVEAGGHGVASGKHAAPISSGAPVGVLHGSKSYLMQDADGQIVETHSVSAGLDYPGVGPEHC
HLKDIGRAEYVSIDDDEALRAFHDCCHLEGIIPALESSHALAWAAKVAPSMGKDQVILVNLSGRGDKDINTVAGLAGITL
>Mature_400_residues
MDRYDFPDAQGHFGPYGGVYVAETLMVALDQLKEEYARVKADPTFWQEFHHELKHYVGRPSPVYHAKRWSEQLGGAQIWF
KREDLNHTGAHKINNAIGQALLARRMGKKRVIAETGAGQHGVATATVAARYGMECVVYMGAEDVKRQSPNVFRMKLLGAT
VVPVESGSKTLKDALNEAMRDWVTNVDSTFYILGTAAGPHPYPMLVRDFVSVIGAESKIQMPEAIGRQPDVVVACVGGGS
NAIGMFHPYIEVPGVRMVGVEAGGHGVASGKHAAPISSGAPVGVLHGSKSYLMQDADGQIVETHSVSAGLDYPGVGPEHC
HLKDIGRAEYVSIDDDEALRAFHDCCHLEGIIPALESSHALAWAAKVAPSMGKDQVILVNLSGRGDKDINTVAGLAGITL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=382, Percent_Identity=56.8062827225131, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321412, Length=383, Percent_Identity=57.1801566579634, Blast_Score=457, Evalue=1e-129,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_CHRVO (Q7NUD8)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902432.2
- ProteinModelPortal:   Q7NUD8
- SMR:   Q7NUD8
- GeneID:   2548517
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2762
- NMPDR:   fig|243365.1.peg.2762
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   Q7NUD8
- ProtClustDB:   PRK04346
- BioCyc:   CVIO243365:CV_2762-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 42969; Mature: 42969

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRYDFPDAQGHFGPYGGVYVAETLMVALDQLKEEYARVKADPTFWQEFHHELKHYVGRP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
SPVYHAKRWSEQLGGAQIWFKREDLNHTGAHKINNAIGQALLARRMGKKRVIAETGAGQH
CCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVATATVAARYGMECVVYMGAEDVKRQSPNVFRMKLLGATVVPVESGSKTLKDALNEAMR
CCHHHHHHHHCCCEEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHH
DWVTNVDSTFYILGTAAGPHPYPMLVRDFVSVIGAESKIQMPEAIGRQPDVVVACVGGGS
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCC
NAIGMFHPYIEVPGVRMVGVEAGGHGVASGKHAAPISSGAPVGVLHGSKSYLMQDADGQI
CCEEEECCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHEEECCCCCE
VETHSVSAGLDYPGVGPEHCHLKDIGRAEYVSIDDDEALRAFHDCCHLEGIIPALESSHA
EEECCCCCCCCCCCCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
LAWAAKVAPSMGKDQVILVNLSGRGDKDINTVAGLAGITL
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDRYDFPDAQGHFGPYGGVYVAETLMVALDQLKEEYARVKADPTFWQEFHHELKHYVGRP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
SPVYHAKRWSEQLGGAQIWFKREDLNHTGAHKINNAIGQALLARRMGKKRVIAETGAGQH
CCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVATATVAARYGMECVVYMGAEDVKRQSPNVFRMKLLGATVVPVESGSKTLKDALNEAMR
CCHHHHHHHHCCCEEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHH
DWVTNVDSTFYILGTAAGPHPYPMLVRDFVSVIGAESKIQMPEAIGRQPDVVVACVGGGS
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCC
NAIGMFHPYIEVPGVRMVGVEAGGHGVASGKHAAPISSGAPVGVLHGSKSYLMQDADGQI
CCEEEECCCEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHEEECCCCCE
VETHSVSAGLDYPGVGPEHCHLKDIGRAEYVSIDDDEALRAFHDCCHLEGIIPALESSHA
EEECCCCCCCCCCCCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
LAWAAKVAPSMGKDQVILVNLSGRGDKDINTVAGLAGITL
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782