Definition Methanocaldococcus jannaschii DSM 2661 chromosome, complete genome.
Accession NC_000909
Length 1,664,970

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The map label for this gene is hemL

Identifier: 161579526

GI number: 161579526

Start: 533791

End: 535059

Strand: Reverse

Name: hemL

Synonym: MJ0603

Alternate gene names: 161579526

Gene position: 535059-533791 (Counterclockwise)

Preceding gene: 15668784

Following gene: 15668782

Centisome position: 32.14

GC content: 35.93

Gene sequence:

>1269_bases
ATGGACAAGTCAAAGGAATTATTTGAAGAGGCTAAAAAATATTTGGTTGGAGGAGTTAATAGTCCAGTTAGATATTTTAA
ACCATATCCATTTTTTGTTGAGAAAGCTAAAGATTGCTATTTATTTGATGTTGATGGAAACTGCTATATTGATTACTGCT
TAGCTTACGGGCCGATGGTTTTAGGGCATGCAAATGATGCTGTGATTAAAGCAGTTAAAGAGCAACTTGAATTAGGAAGT
GCTTATGGATGCCCAACAGAGAAAGAGATTATTTTAGCTAAAGAGGTTGTTAAAAGAGTTCCATGTGCTGAGATGGTTAG
ATTTGTTAATTCTGGGACTGAGGCGACGATGTCAGCTATAAGATTGGCAAGAGGAGTTACTGGAAGGAAGAAGATTATTA
AGTTTGATGGAGCTTATCATGGAGCTCATGACTATGTTTTGGTTAAGAGTGGAAGTGGTGCTCTAACCCACGGACATCCA
AACTCTCCAGGAATCCCAGAAGAGACAACAAAAAATACTATCTTAATTCCGTTTAATGATGAAGATGCTGTAAAAAAAGC
AATAAATGAAAATAAAGATGAAATTGCCTGTATTATAGTTGAGCCAATTATGGGAAATGTTGGTTGTATATTACCAAAAG
AAGGTTATTTAGAGTTTTTAAGAGAGATAACTGAGGAAAATGATATTTTGTTGATATTTGATGAGGTTATAACTGGGTTT
AGATTAGCTAAGGGAGGAGCTCAGGAGTATTTTGGAGTAGTTCCAGATATAGCTACCTTAGGAAAGATATTGGGAGGAGG
ATTTCCAATCGGTGCTATTGTGGGGAGAAGAGAGCTTATGGAGCAGTTTTCTCCATTGGGAGCTATATATCAAGCAGGAA
CATTCAACGGAAATCCAATATCAATAACTGCTGGAATCGCCACTCTTAAGCAGTTGGATGATAGGTTTTATAAAGAAACA
GCAAGAACTGCTAAGATATTGGCAGATACTTTAAGAGAGTTGGCTGATAAACATAATATTAAAGCTAAGGTTTATAACAT
TGCTTCAATGTTCCAAATCTACTTCAATGATAAGGAAGTTGTGAATTATGAGATTGCCAAGCAGAGTGATACTGAGAAAT
TTATGAAATACTTCTGGAGATTGTTGGAGAAAGGGGTTTTTGTTCCTCCTTCACAGTTTGAATGTTGCTTTACCTCAATA
AAACATGATGATGAGGTTGTTGATAAGACAATAAAGGCTATGGAGGATGTGTTTGAGGGTTTAGAATAA

Upstream 100 bases:

>100_bases
AAGGAAGAGTGTTGTATTAAGAATAAAATCGATGGTTAATTCCTCTCCATTATGGAAGAAGTTAATGAGAAAATGTAAAG
GTGAAAATATGGCCTTAAAA

Downstream 100 bases:

>100_bases
TTTTAACTTATTTTTATAATTTTCTCTTAAGGGATTCAAATGCTGTTAGAAAAAAGCAAAATAGAGATTATTGAGCAATT
TATACATATTTTAGAAATTT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MDKSKELFEEAKKYLVGGVNSPVRYFKPYPFFVEKAKDCYLFDVDGNCYIDYCLAYGPMVLGHANDAVIKAVKEQLELGS
AYGCPTEKEIILAKEVVKRVPCAEMVRFVNSGTEATMSAIRLARGVTGRKKIIKFDGAYHGAHDYVLVKSGSGALTHGHP
NSPGIPEETTKNTILIPFNDEDAVKKAINENKDEIACIIVEPIMGNVGCILPKEGYLEFLREITEENDILLIFDEVITGF
RLAKGGAQEYFGVVPDIATLGKILGGGFPIGAIVGRRELMEQFSPLGAIYQAGTFNGNPISITAGIATLKQLDDRFYKET
ARTAKILADTLRELADKHNIKAKVYNIASMFQIYFNDKEVVNYEIAKQSDTEKFMKYFWRLLEKGVFVPPSQFECCFTSI
KHDDEVVDKTIKAMEDVFEGLE

Sequences:

>Translated_422_residues
MDKSKELFEEAKKYLVGGVNSPVRYFKPYPFFVEKAKDCYLFDVDGNCYIDYCLAYGPMVLGHANDAVIKAVKEQLELGS
AYGCPTEKEIILAKEVVKRVPCAEMVRFVNSGTEATMSAIRLARGVTGRKKIIKFDGAYHGAHDYVLVKSGSGALTHGHP
NSPGIPEETTKNTILIPFNDEDAVKKAINENKDEIACIIVEPIMGNVGCILPKEGYLEFLREITEENDILLIFDEVITGF
RLAKGGAQEYFGVVPDIATLGKILGGGFPIGAIVGRRELMEQFSPLGAIYQAGTFNGNPISITAGIATLKQLDDRFYKET
ARTAKILADTLRELADKHNIKAKVYNIASMFQIYFNDKEVVNYEIAKQSDTEKFMKYFWRLLEKGVFVPPSQFECCFTSI
KHDDEVVDKTIKAMEDVFEGLE
>Mature_422_residues
MDKSKELFEEAKKYLVGGVNSPVRYFKPYPFFVEKAKDCYLFDVDGNCYIDYCLAYGPMVLGHANDAVIKAVKEQLELGS
AYGCPTEKEIILAKEVVKRVPCAEMVRFVNSGTEATMSAIRLARGVTGRKKIIKFDGAYHGAHDYVLVKSGSGALTHGHP
NSPGIPEETTKNTILIPFNDEDAVKKAINENKDEIACIIVEPIMGNVGCILPKEGYLEFLREITEENDILLIFDEVITGF
RLAKGGAQEYFGVVPDIATLGKILGGGFPIGAIVGRRELMEQFSPLGAIYQAGTFNGNPISITAGIATLKQLDDRFYKET
ARTAKILADTLRELADKHNIKAKVYNIASMFQIYFNDKEVVNYEIAKQSDTEKFMKYFWRLLEKGVFVPPSQFECCFTSI
KHDDEVVDKTIKAMEDVFEGLE

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=431, Percent_Identity=26.4501160092807, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI37574042, Length=384, Percent_Identity=28.125, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI226442705, Length=384, Percent_Identity=27.0833333333333, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI226442709, Length=348, Percent_Identity=27.8735632183908, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24119277, Length=393, Percent_Identity=26.4631043256997, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=27.0769230769231, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI13994255, Length=341, Percent_Identity=27.5659824046921, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=49.2957746478873, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1789016, Length=367, Percent_Identity=29.9727520435967, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI145693181, Length=335, Percent_Identity=32.5373134328358, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789759, Length=287, Percent_Identity=31.7073170731707, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787560, Length=394, Percent_Identity=28.4263959390863, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788044, Length=285, Percent_Identity=30.5263157894737, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786991, Length=294, Percent_Identity=28.2312925170068, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25144271, Length=347, Percent_Identity=28.5302593659942, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=365, Percent_Identity=27.3972602739726, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=162, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=334, Percent_Identity=28.7425149700599, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=358, Percent_Identity=26.2569832402235, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21357415, Length=323, Percent_Identity=29.1021671826625, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161085790, Length=359, Percent_Identity=26.4623955431755, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574759, Length=359, Percent_Identity=26.4623955431755, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_METJA (Q58020)

Other databases:

- EMBL:   L77117
- PIR:   C64375
- RefSeq:   NP_247585.2
- ProteinModelPortal:   Q58020
- SMR:   Q58020
- GeneID:   1451468
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0603
- NMPDR:   fig|243232.1.peg.622
- TIGR:   MJ0603
- HOGENOM:   HBG725944
- OMA:   SFISSVH
- ProtClustDB:   PRK00062
- BioCyc:   MJAN243232:MJ_0603-MONOMER
- BRENDA:   5.4.3.8
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 47008; Mature: 47008

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSKELFEEAKKYLVGGVNSPVRYFKPYPFFVEKAKDCYLFDVDGNCYIDYCLAYGPMV
CCCHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHCCCCEEEEECCCCEEEHHHHHHCCEE
LGHANDAVIKAVKEQLELGSAYGCPTEKEIILAKEVVKRVPCAEMVRFVNSGTEATMSAI
EECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
RLARGVTGRKKIIKFDGAYHGAHDYVLVKSGSGALTHGHPNSPGIPEETTKNTILIPFND
HHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEEECC
EDAVKKAINENKDEIACIIVEPIMGNVGCILPKEGYLEFLREITEENDILLIFDEVITGF
HHHHHHHHCCCCCCEEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHH
RLAKGGAQEYFGVVPDIATLGKILGGGFPIGAIVGRRELMEQFSPLGAIYQAGTFNGNPI
HHCCCCHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCE
SITAGIATLKQLDDRFYKETARTAKILADTLRELADKHNIKAKVYNIASMFQIYFNDKEV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCE
VNYEIAKQSDTEKFMKYFWRLLEKGVFVPPSQFECCFTSIKHDDEVVDKTIKAMEDVFEG
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
LE
CC
>Mature Secondary Structure
MDKSKELFEEAKKYLVGGVNSPVRYFKPYPFFVEKAKDCYLFDVDGNCYIDYCLAYGPMV
CCCHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHCCCCEEEEECCCCEEEHHHHHHCCEE
LGHANDAVIKAVKEQLELGSAYGCPTEKEIILAKEVVKRVPCAEMVRFVNSGTEATMSAI
EECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHH
RLARGVTGRKKIIKFDGAYHGAHDYVLVKSGSGALTHGHPNSPGIPEETTKNTILIPFND
HHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEEECC
EDAVKKAINENKDEIACIIVEPIMGNVGCILPKEGYLEFLREITEENDILLIFDEVITGF
HHHHHHHHCCCCCCEEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEHHHHHHH
RLAKGGAQEYFGVVPDIATLGKILGGGFPIGAIVGRRELMEQFSPLGAIYQAGTFNGNPI
HHCCCCHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCE
SITAGIATLKQLDDRFYKETARTAKILADTLRELADKHNIKAKVYNIASMFQIYFNDKEV
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCE
VNYEIAKQSDTEKFMKYFWRLLEKGVFVPPSQFECCFTSIKHDDEVVDKTIKAMEDVFEG
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
LE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087