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The map label for this gene is map

Identifier: 161579048

GI number: 161579048

Start: 279359

End: 280234

Strand: Reverse

Name: map

Synonym: TC0240

Alternate gene names: 161579048

Gene position: 280234-279359 (Counterclockwise)

Preceding gene: 15834861

Following gene: 15834857

Centisome position: 26.12

GC content: 41.1

Gene sequence:

>876_bases
ATGAAAAGAAATGACCCTTGCTGGTGTGGCAGTCAGAAAAAATGGAAACACTGCCACTACCCTACAAAGCCAGAACGTCC
TAGTGACAATTTAAGACAGCTCTATGCTTCTCGTTACGATATTATCATCAAAACTCCTGATCAAATAGAGAAGATTCGTA
AAGCTTGCCAAGTTACAGCTCGAATTCTTGATGCTTTATGTAAAGCTGCTAAAGAGGGAGTAACTACAAATGAACTCGAT
CAACTCTCTTGTAATCTACATAAACAGTATAATGCCATTCCAGCTCCCCTAAATTACGGGCAGCCACCTTTTCCAAAAAC
TATTTGTACTTCTCTTAACGAAGTTATTTGCCATGGGATCCCCAATGATACCCCTTTACAAAATGGCGATATTATGAACA
TTGATGTCTCTTGCATTGTAGATGGATTTTATGGAGACTGTAGCCGAATGGTTATGATTGGAGAAGTACCAGAGATCAAA
AAAAAGGTCTGTGAAGCTTCTCTAGAAGCTCTTAACGCCGCTATTGCTATCTTAGAACCCAATCTTCCTCTTTACGAAAT
TGGCGAAGTGATTGAAAATTGTGCTGCCAGATATGGGTTCTCTGTTGTTGATCAATTTGTCGGACATGGAGTGGGAGTAA
GATTCCATGAAAATCCCTATGTTGCACACCATAGAAATTCGTGTAAGATTCCTTTGGCTCCTGGGATGACCTTTACTATC
GAACCTATGATCAATGTAGGGAAGAAGGAGGGATTCATTGACCCCACGAACCACTGGGAAGCAAGAACCTGTGACCACCA
GCCTAGCGCACAGTGGGAGCACACAGTGCTTATCACAGATTCTGGTTATGAAATACTAACTCTTCTAGATAATTGA

Upstream 100 bases:

>100_bases
AGCTTTCAATATAGGGTATTATGTTATGGCCTAGAGTATTCCCTCTATTTTCAATAGAAAGAAAAAAAACAATCAAAAAC
CACTTCTTTTGGTTCCTTGT

Downstream 100 bases:

>100_bases
TTTCTTCTTCTAGCGCCTCAATCTGTAATAAAAGGTTTTGAATAATAAAAAAACTATCCATCGTGGACGGATCTGAGGCT
TCTTCTTCCTCTTCCCGTTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTARILDALCKAAKEGVTTNELD
QLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGIPNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIK
KKVCEASLEALNAAIAILEPNLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTI
EPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN

Sequences:

>Translated_291_residues
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTARILDALCKAAKEGVTTNELD
QLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGIPNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIK
KKVCEASLEALNAAIAILEPNLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTI
EPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN
>Mature_291_residues
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTARILDALCKAAKEGVTTNELD
QLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGIPNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIK
KKVCEASLEALNAAIAILEPNLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTI
EPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=43.3734939759036, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI164420681, Length=307, Percent_Identity=38.1107491856677, Blast_Score=184, Evalue=6e-47,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=44.8412698412698, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788728, Length=287, Percent_Identity=22.9965156794425, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=274, Percent_Identity=40.1459854014599, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=42.8, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=43.5483870967742, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=39.5918367346939, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_CHLMU (Q9PL68)

Other databases:

- EMBL:   AE002160
- PIR:   G81724
- RefSeq:   NP_296619.2
- ProteinModelPortal:   Q9PL68
- SMR:   Q9PL68
- MEROPS:   M24.001
- GeneID:   1246409
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0240
- TIGR:   TC_0240
- HOGENOM:   HBG299384
- ProtClustDB:   PRK12318
- BioCyc:   CMUR243161:TC_0240-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804:SF13
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00500

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 32647; Mature: 32647

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00680 MAP_1

Important sites: BINDING 118-118 BINDING 216-216

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
RILDALCKAAKEGVTTNELDQLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIKKKVCEASLEALNAAIAILEP
CCCCCCCCCCEEEEEHEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEECC
NLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTI
CCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCEEECCCCCCEEECCCCEEEE
EPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
RILDALCKAAKEGVTTNELDQLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIKKKVCEASLEALNAAIAILEP
CCCCCCCCCCEEEEEHEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEECC
NLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTI
CCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCEEECCCCCCEEECCCCEEEE
EPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935