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The map label for this gene is gyrA [H]

Identifier: 161525434

GI number: 161525434

Start: 2478091

End: 2480694

Strand: Reverse

Name: gyrA [H]

Synonym: Bmul_2264

Alternate gene names: 161525434

Gene position: 2480694-2478091 (Counterclockwise)

Preceding gene: 161525438

Following gene: 161525433

Centisome position: 71.94

GC content: 64.82

Gene sequence:

>2604_bases
ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAG
CGTGATCGTCGGACGTGCCCTCCCGGATGTCCGCGATGGCCTGAAGCCCGTGCACCGGCGCGTACTGTTCGCGATGCACG
AACTGAACAACGACTGGAACCGGGCCTACAAGAAGTCGGCGCGTATCGTCGGCGACGTGATCGGTAAATACCACCCGCAC
GGCGACAGCGCGGTCTACGAAACGATCGTGCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGGTCGACGGGCAAGG
CAACTTCGGCTCGATCGACGGCGACAACGCCGCCGCGATGCGTTACACCGAAATTCGCATGGCGAAGATCGGTCACGAGC
TGCTTGCCGACATCGACAAGGAAACGGTCGACTTCGGCCCGAACTACGACGGCAGCGAAATGCAGCCGCTGATCCTGCCC
GCGCGGATCCCGAACCTGCTGATCAACGGTTCGTCGGGCATCGCGGTCGGCATGGCCACCAACATTCCGCCGCACAACCT
GAACGAAGTCGTCGATGCCTGCCAGCATCTGCTGAACAATCCCGACGCGACGATCGACGAGCTGATCGAGATCATCCCGG
CGCCCGATTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTACCGCACCGGGCGCGGCCGCGTC
GTGATGCGCGCGGCCACGCACTTCGAGGAAATCGACCGCGGCCAGCGCATGGCGATCATCGTCGACGAGCTGCCGTACCA
GGTCAACAAGCGCTCGCTGCTCGAGCGCATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAGGGCATCTCCGATATCCGCG
ACGAGTCCGACAAGAGCGGCATGCGCGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTC
TACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACGGCCAGCCGAAGCTGCTGAACCT
GAAGGAAATCCTTCAGTGCTTCCTGTCGCACCGCCGCGAAGTGCTGACGCGCCGCACGGTCTACGAACTGCGCAAGGCGC
GCGAACGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAATTCATCGCGATCATCAAGGCCGCG
CCGACGCCGCCGATCGCGAAGCAGGAACTGATGGCGAAGGCGTGGGATTCGTCGCTCGTGCGCGAGATGCTCACGCGCGC
CGAAGCCGAGAACGCGGCGGCCGGCGGCCGCGCGGCGTATCGTCCGGAAGGGCTGAACCCGGCGTTCGGGATGCAGGGCG
ACGGGCTCTACAAGCTGTCCGACACGCAGGCGCAGGAAATTCTGCAGATGCGTCTGCAGCGCCTGACGGGCCTCGAGCAG
GACAAGATCATCGGCGAGTATCGCGACGTGATGGCGCAGATCTCCGATCTGCTCGACATCCTCGCGCGTCCGGAGCGGAT
CACGACGATGATCGGCGAAGAGCTGACCACGGTGAAGGCCGAGTTCGGCGACGCGCGCCGCTCGAAGATCGAGCTGAACG
CGACCGAGCTCAACACCGAAGACCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCACGCGGGCTACGTGAAGTCG
CAGCCGCTGTCCGAGTACCGCGCGCAGAAGCGCGGCGGTCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGAT
CGAGACGCTGTTCATCGCGAACACGCACGATTACATGCTCTGCTTCTCGAACCGCGGCCGCGTGTACTGGATCAAGGTCT
ACGAGGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGACGGCGAGAAGATC
AACGTCGTGCTGCCGGTGAAGGAATTCTCGGCCGACAAGTTCGTGTTCATGGCGACGTCGCTCGGCACCGTGAAGAAGAC
GCCGCTCGAGGCATTCAGCCGACCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTACCTGATCGGCG
CGTCGATCACCGACGGTGCGCACGACGTGATGCTGTTCTCCGACGCCGGCAAGGCCGTGCGCTTCGACGAGAACGACGTG
CGGCCGATGGGGCGCGAAGCGCGCGGCGTGCGCGGCATGCAGCTCGACGAAGGGCAGCAGGTCATCGCGCTGCTGGTGGC
CGGCAGCGAAGACCAGTCGGTGCTCACCGCGACCGAGAACGGCTTCGGCAAGCGCACGCCGATCACCGAATACACGCGCC
ACGGCCGCGGCACGAAGGGTATGATCGCGATCCAGACGTCCGAGCGTAACGGCAAGGTCGTCGCGGCGACGCTCGTCGAC
GCCGAAGACCAGATCATGCTGATCACGACGGCCGGCGTGCTGATCCGCACGCGCGTGTCGGAGATCCGCGAGATGGGACG
CGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGTACGAAGCTCTCTGGCCTGCAGCAGATCGCCGAGGCCGAGG
ACGGTGACGGCGAAGCCGACGAGGCGTCGGACGGCGAAGCCTGA

Upstream 100 bases:

>100_bases
TTGGCGGCTGTTGGGCGCATGTTAGAATCTCACGTTGCGTTGCGCATGCATCGCTCACGCGAAAGGCGTTCCCGTCTTCG
CTCCGAAAAGATACGGATAC

Downstream 100 bases:

>100_bases
ACGGATGAGACTCTCGGGCCGCCGCACGCGTGCCGCGCAAGCGGGTGAGCGCAGCACGCTGCGATCGGCGAGAAAACATT
CATATTTCCAAGAGGGAGTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 867

Protein sequence:

>867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA

Sequences:

>Translated_867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA
>Mature_867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV
RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=378, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI19913406, Length=320, Percent_Identity=25.625, Blast_Score=91, Evalue=5e-18,
Organism=Escherichia coli, GI1788562, Length=870, Percent_Identity=60, Blast_Score=1047, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=725, Percent_Identity=36.2758620689655, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=493, Percent_Identity=25.7606490872211, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=379, Percent_Identity=25.5936675461741, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=171, Percent_Identity=31.5789473684211, Blast_Score=73, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.8011527377522, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.647564469914, Blast_Score=93, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96084; Mature: 96084

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKAWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYML
HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKFVFMATS
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC
LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEAEDGDGEADEASDGEA
CCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKAWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYML
HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKFVFMATS
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC
LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC
RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKG
CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC
MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQIAEAEDGDGEADEASDGEA
CCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]