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The map label for this gene is cysM [H]

Identifier: 161525419

GI number: 161525419

Start: 2462898

End: 2463800

Strand: Reverse

Name: cysM [H]

Synonym: Bmul_2249

Alternate gene names: 161525419

Gene position: 2463800-2462898 (Counterclockwise)

Preceding gene: 161525420

Following gene: 161525417

Centisome position: 71.45

GC content: 63.9

Gene sequence:

>903_bases
ATGGCTTACAAAACTATCGAAGACACGATCGGCAACACGCCGCTCGTGCAACTGGTCCGCCTGCCGGACGACGAGATTCG
CGCTCGCAACAACGTAATTCTCGCGAAGCTGGAGGGCAACAATCCGGCCGGGTCCGTGAAGGATCGCCCGGCGCTGTCGA
TGATCAGCAAGGCCGAGGCACGCGGCCGCATCAAGCCGGGCGATACGCTGATCGAAGCGACGAGCGGCAACACCGGCATC
GCGCTCGCGATGGCCGCCGCGATCCGCGGCTACAAGATGGTGTTGATCATGCCCGAGGATTTGTCGGTCGAGCGTCGGCA
AAGCATGGCCGCGTACGGCGCCGAGATCATCCTGACGCCGGTGAAGGGCGGGATGGAACTGGCGCGCGATCTCGCGGAGC
AGATGCAGCGTGAAGGCAAGGGCGTGATCCTCGATCAATTCGGCAATCCCGACAATCCGATCGCGCACTACGAAGGCACC
GGCCCGGAGATCTGGCGCGACACCGAAGGGCGCGTCACGCACTTCGTGTCCGCGATGGGCACGACGGGCACGATCATGGG
CACGTCGCGCTATCTGAAGGAACAGAATCCGGCGATCGAGATCATCGGTGCGCAGCCGGAAGACGGCTCGCGCATTCCGG
GCATTCGCAAGTGGCCGGAAGCCTATATGCCGACGATTTTCGATCGCAGCCGCGTCGACCGCGTCGAGAACGTGAGCCAG
GCCGCAGCCGAAACGATGGCGCGCCGGCTGGCATCGGTCGAAGGCATTTTTGCCGGCATTTCGTCGGGCGGCGCATGCGA
AGTCGCGATGCGCATCGCGCGTCAGGTCGAGAACGCGACGATCGTCTTCATCATCTGCGATCGCGGCGACCGCTATCTGT
CCACCGGCGTGTTTCCGGCGTGA

Upstream 100 bases:

>100_bases
CACGTCGCGTATTCCATCGTTGCAATGTGGGTTGCGGGCGCGGTGACGGGCGGTGGTTTACAATCGATCGATTGATCGGC
CTCGCACTCACGGTATCTCC

Downstream 100 bases:

>100_bases
CGCTGCGCGGCTCGCACGGGCCGCGCTTCAACAACAAAAAACGCCGCATGCAGCGGCGTTTTTTGTTGATGGCGGGCGGG
ATTACTGCGACGTCGACTGC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLAEQMQREGKGVILDQFGNPDNPIAHYEGT
GPEIWRDTEGRVTHFVSAMGTTGTIMGTSRYLKEQNPAIEIIGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIICDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLAEQMQREGKGVILDQFGNPDNPIAHYEGT
GPEIWRDTEGRVTHFVSAMGTTGTIMGTSRYLKEQNPAIEIIGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIICDRGDRYLSTGVFPA
>Mature_299_residues
AYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGIA
LAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLAEQMQREGKGVILDQFGNPDNPIAHYEGTG
PEIWRDTEGRVTHFVSAMGTTGTIMGTSRYLKEQNPAIEIIGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQA
AAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIICDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=38.4364820846906, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=38.4364820846906, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=38.4364820846906, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=62.3728813559322, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=43.217665615142, Blast_Score=203, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=42.6229508196721, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=44.0397350993377, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=44.7811447811448, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40.6666666666667, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.7218543046358, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=34.9056603773585, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=35.9621451104101, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=39.1509433962264, Blast_Score=143, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=39.873417721519, Blast_Score=185, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=31.4199395770393, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=38.961038961039, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=38.961038961039, Blast_Score=178, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32521; Mature: 32389

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMISKAEA
CCCCCHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMELARDLAEQMQREGKGVILDQFGNPDNPIAHYEGTGPEIWRDTEGRVTHFVSAMG
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCEECCCCHHHHHHHHCC
TTGTIMGTSRYLKEQNPAIEIIGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
CCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIICDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYKTIEDTIGNTPLVQLVRLPDDEIRARNNVILAKLEGNNPAGSVKDRPALSMISKAEA
CCCCHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMELARDLAEQMQREGKGVILDQFGNPDNPIAHYEGTGPEIWRDTEGRVTHFVSAMG
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCCCCEECCCCHHHHHHHHCC
TTGTIMGTSRYLKEQNPAIEIIGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
CCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIICDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]