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The map label for this gene is mucB [H]

Identifier: 161525345

GI number: 161525345

Start: 2392452

End: 2393504

Strand: Reverse

Name: mucB [H]

Synonym: Bmul_2175

Alternate gene names: 161525345

Gene position: 2393504-2392452 (Counterclockwise)

Preceding gene: 161525346

Following gene: 161525344

Centisome position: 69.41

GC content: 67.05

Gene sequence:

>1053_bases
ATGCGGACATTGCGGTTGAATCACGCCATCTCCGGATGGAAGCGGCTGCCGGCCCTCCTGCTTTGCGCAGCCGCGCTGTT
GTCCGTTCAATCCCTTCCTGCCAGCGCCCAGCAACCGGACGATCCCGTCGCGACCCGCAAGGGCGCCGCGGAATGGCTCG
ACCGCATCCAGCAGGCGGCGCGGCAGCAGACCTACGAAGGCACGTTCGTCTATCAGCGCGGCGGCTACGTCCAGTCGTCG
CGCATCGCGCACATCGCGTCGCGCGACGGCGAGTTCGAACGGATCGAAACGCTCGACGGCAAGCCGCGCAAGCTGCTGCG
CCATAACGACGAACTCTATACCTTCGTGCCCGAGCGCAAGCTCTGCGTGGTCGAACGCCGGCAAACGCGCGATTCGTTCC
CCGCGTTGCTCGGCGCGAGCGGCGAGCACGTGATGTCCGTCTACGACGCGAAGCTGCTCGGCAAGGATCGCGTCGCCGGC
ATCGACGCGCAGGTCGTCGAACTCGTCCCGAAGGACGCCTATCGTTTTACGTACAAGCTGTGGGTCGATGCGCGCACGGG
CCTGCTGTTGCGCTCGCAGACGCTCGACGCGAACGATCGCGTGCTCGAGCAGATCGCGTTCTCACAGCTGCAGACGGGCG
CGGCCGGCGGCGACAAGGCCGCGATCGCGGCCGGCATGCGTAACCTCGGCGGCTGGACGGTCGTCCGTCCGCCGGTGGCG
ACGGTCGACATGGAGGCGCAGGGCTGGCAGATCGCACCGGGCGTCGCGGGCTTCCAGAAGATCCGCGAGGTACGCCGGCC
GATGGCTGCGCGCGATGCGGGCGATCCGCCGATCGCGGTCGATCAGGCCGTGTTCACCGACGGGCTCGCGACGATCTCGG
TCTTCATCGAACCAGCCGAAAAGAATACGCGCAAGGAAGGCGCGGGCAGCACCGGCGCGACGCACGTGCTCGTCAAGCGC
CGCGGCGACTACTGGATCACCGTGCTCGGCGAAGTGCCGCCGGCAACGTTGCAGCAGTTCGCGTCTGCCATAGAATACAA
GGCTTCCAAGTAA

Upstream 100 bases:

>100_bases
ACCTTGAAGCGCACCAGCAATTCGCGCAGCAGCCCGTCGTCACGGGCTCGATGCCGCTGATCCGCGCTGCCGTGTCCACC
ACGCCAGGCCAATAAACTCG

Downstream 100 bases:

>100_bases
CGCTACGGCTTCCGACATGATGAAAATCACGCTGCGCAAATGGCTTGCGGCGGCGGCGCTGTCCGCCTGCCTGCCGCTCG
TGCCGCACACCGCGGCCGCC

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRTLRLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAARQQTYEGTFVYQRGGYVQSS
RIAHIASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKLLGKDRVAG
IDAQVVELVPKDAYRFTYKLWVDARTGLLLRSQTLDANDRVLEQIAFSQLQTGAAGGDKAAIAAGMRNLGGWTVVRPPVA
TVDMEAQGWQIAPGVAGFQKIREVRRPMAARDAGDPPIAVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Sequences:

>Translated_350_residues
MRTLRLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAARQQTYEGTFVYQRGGYVQSS
RIAHIASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKLLGKDRVAG
IDAQVVELVPKDAYRFTYKLWVDARTGLLLRSQTLDANDRVLEQIAFSQLQTGAAGGDKAAIAAGMRNLGGWTVVRPPVA
TVDMEAQGWQIAPGVAGFQKIREVRRPMAARDAGDPPIAVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK
>Mature_350_residues
MRTLRLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAARQQTYEGTFVYQRGGYVQSS
RIAHIASRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKLLGKDRVAG
IDAQVVELVPKDAYRFTYKLWVDARTGLLLRSQTLDANDRVLEQIAFSQLQTGAAGGDKAAIAAGMRNLGGWTVVRPPVA
TVDMEAQGWQIAPGVAGFQKIREVRRPMAARDAGDPPIAVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=304, Percent_Identity=24.6710526315789, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 38390; Mature: 38390

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLRLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHH
RQQTYEGTFVYQRGGYVQSSRIAHIASRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHHCCCCEEEEECCCEECCCHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKLLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEE
WVDARTGLLLRSQTLDANDRVLEQIAFSQLQTGAAGGDKAAIAAGMRNLGGWTVVRPPVA
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCE
TVDMEAQGWQIAPGVAGFQKIREVRRPMAARDAGDPPIAVDQAVFTDGLATISVFIEPAE
EEEECCCCCEECCCHHHHHHHHHHHCCHHHCCCCCCCCEECHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLRLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHH
RQQTYEGTFVYQRGGYVQSSRIAHIASRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHHCCCCEEEEECCCEECCCHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKLLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEE
WVDARTGLLLRSQTLDANDRVLEQIAFSQLQTGAAGGDKAAIAAGMRNLGGWTVVRPPVA
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCE
TVDMEAQGWQIAPGVAGFQKIREVRRPMAARDAGDPPIAVDQAVFTDGLATISVFIEPAE
EEEECCCCCEECCCHHHHHHHHHHHCCHHHCCCCCCCCEECHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]