Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 161525341

GI number: 161525341

Start: 2387763

End: 2388656

Strand: Reverse

Name: lepB [H]

Synonym: Bmul_2171

Alternate gene names: 161525341

Gene position: 2388656-2387763 (Counterclockwise)

Preceding gene: 161525342

Following gene: 161525340

Centisome position: 69.27

GC content: 61.74

Gene sequence:

>894_bases
ATGAATTTTGCGCTGATTCTTTTTGTGCTCGTCATCGTGACGGGCGTGGCGTGGGTGCTCGACAAACTGGTGTTCCTGCC
GCGCCGCCGCAAGGCGGCCGAGGCGGCGGTCGAAGAGTTCGACCGCCAGCAGTCGCGGATCGACAAGCGTTTCGCGGACG
AAAACGCGGTGCAGACGCGCTCGAAGCTGCGCGACGAGAAGCTGCGTCAGCCGTGGTGGCTCGAATACACGGCGAGCTTT
TTCCCGGTGATTCTCGCGGTGTTCGTCGTGCGTTCGTTCATCGTCGAGCCGTTCAAGATTCCGTCGGGCTCGATGGTGCC
GACGCTGCTCGTCGGCGACTTCATCCTCGTGAACAAGTTCGAGTACGGGCTGCGCATGCCGATCACGAACACGAAGATCA
CGCAGGGCAGCCCGCTCGCGCGCGGCGACGTCGTCGTGTTCCGCTACCCGAAGGACGAATCGGTCGACTACATCAAGCGC
GTGATCGGTCTGCCGGGCGATACGGTCGCGTATCAGGACAAGCAGCTGACGATCAACGGCCAGCCGGTGCCCGAAACGCC
GCTGCCCGATTACTTCGACGACGAGCGGCAGAACTACGCGAAGCAGTTCGAGGAGACGATCGGCAACAAGAAGAACGCGA
TCCTCAACAACCCGGCCGTGCCGCCGTTCGTGATGGGCGCATACGACTATCCGTATCGCGACAACTGCACGTACAACAGC
CGCGGCGTGATCTGCAAGGTGCCGCCGGGCCACTACTTCATGATGGGCGACAACCGCGACAACAGCGCGGACAGCCGCTA
CTGGGGCTTCGTGCCTGACAAGAACATCGTGGGCCGCGCCTTCTTCATCTGGATGAACTTCAGCGACCTCAAGCGCATCG
GTTCCTTCAACTGA

Upstream 100 bases:

>100_bases
GGCAAGAAACGAATGAAGCAGGTGGGTTCGGTCGAGATCCCGCAGGAGGCGTTCCTCGCGATCTTGCGCGTCGAAGACAA
ATAACAGGACTGATCCTTTT

Downstream 100 bases:

>100_bases
TCGCGCTCGGCTCGCATGCAATACGCGGCGCACGGGCCGCGCCGCGTATTGCCGAACTACTTTAAAAACCGGCGGTAACA
CCGCTTCGTCACGCCTTTTC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNFALILFVLVIVTGVAWVLDKLVFLPRRRKAAEAAVEEFDRQQSRIDKRFADENAVQTRSKLRDEKLRQPWWLEYTASF
FPVILAVFVVRSFIVEPFKIPSGSMVPTLLVGDFILVNKFEYGLRMPITNTKITQGSPLARGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKQLTINGQPVPETPLPDYFDDERQNYAKQFEETIGNKKNAILNNPAVPPFVMGAYDYPYRDNCTYNS
RGVICKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN

Sequences:

>Translated_297_residues
MNFALILFVLVIVTGVAWVLDKLVFLPRRRKAAEAAVEEFDRQQSRIDKRFADENAVQTRSKLRDEKLRQPWWLEYTASF
FPVILAVFVVRSFIVEPFKIPSGSMVPTLLVGDFILVNKFEYGLRMPITNTKITQGSPLARGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKQLTINGQPVPETPLPDYFDDERQNYAKQFEETIGNKKNAILNNPAVPPFVMGAYDYPYRDNCTYNS
RGVICKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
>Mature_297_residues
MNFALILFVLVIVTGVAWVLDKLVFLPRRRKAAEAAVEEFDRQQSRIDKRFADENAVQTRSKLRDEKLRQPWWLEYTASF
FPVILAVFVVRSFIVEPFKIPSGSMVPTLLVGDFILVNKFEYGLRMPITNTKITQGSPLARGDVVVFRYPKDESVDYIKR
VIGLPGDTVAYQDKQLTINGQPVPETPLPDYFDDERQNYAKQFEETIGNKKNAILNNPAVPPFVMGAYDYPYRDNCTYNS
RGVICKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=323, Percent_Identity=42.1052631578947, Blast_Score=220, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34155; Mature: 34155

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLVIVTGVAWVLDKLVFLPRRRKAAEAAVEEFDRQQSRIDKRFADENAVQTR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SKLRDEKLRQPWWLEYTASFFPVILAVFVVRSFIVEPFKIPSGSMVPTLLVGDFILVNKF
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEEC
EYGLRMPITNTKITQGSPLARGDVVVFRYPKDESVDYIKRVIGLPGDTVAYQDKQLTING
CCCEECCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPVPETPLPDYFDDERQNYAKQFEETIGNKKNAILNNPAVPPFVMGAYDYPYRDNCTYNS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCCCCCCCC
RGVICKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
CCEEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHCCCC
>Mature Secondary Structure
MNFALILFVLVIVTGVAWVLDKLVFLPRRRKAAEAAVEEFDRQQSRIDKRFADENAVQTR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SKLRDEKLRQPWWLEYTASFFPVILAVFVVRSFIVEPFKIPSGSMVPTLLVGDFILVNKF
HHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEEC
EYGLRMPITNTKITQGSPLARGDVVVFRYPKDESVDYIKRVIGLPGDTVAYQDKQLTING
CCCEECCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPVPETPLPDYFDDERQNYAKQFEETIGNKKNAILNNPAVPPFVMGAYDYPYRDNCTYNS
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCCCCCCCCCCCCCC
RGVICKVPPGHYFMMGDNRDNSADSRYWGFVPDKNIVGRAFFIWMNFSDLKRIGSFN
CCEEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]