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The map label for this gene is rnc [H]

Identifier: 161525340

GI number: 161525340

Start: 2386389

End: 2387609

Strand: Reverse

Name: rnc [H]

Synonym: Bmul_2170

Alternate gene names: 161525340

Gene position: 2387609-2386389 (Counterclockwise)

Preceding gene: 161525341

Following gene: 161525339

Centisome position: 69.24

GC content: 70.02

Gene sequence:

>1221_bases
ATGCCCCTATCCCAGTTGGAAAGCCGGCTGCGCTACGAATTTCGCAATGCGGAATTGTTGCGCCAGGCTTTGACCCATCG
CAGTCACAGTGCCACGCACAACGAGCGGCTCGAGTTTCTCGGCGATTCCGTTCTGAATTGCGCGGTGGCCGCCCTTTTGT
TCCAGCGTTTCGGCAAGCTCGACGAAGGGGACCTGTCGCGCGTGCGCGCGAATCTCGTCAAGCAGCAGTCGCTGTACGAA
ATCGCTCAGGCCCTCAATATCTCCGAAGGCTTGCGGCTCGGTGAAGGCGAGCTGCGCAGCGGCGGCTTCCGCCGCCCGTC
GATCCTCGCGGACGCATTCGAAGCCATCATCGGGGCCGTGTTCCTCGATGGCGGCTTCGAAGCCGCCCAAGGGGTCATCA
AGCGCCTTTACGTGCCGATCCTCGACCACATCGATCCGCGCACGCTCGGCAAGGACGCCAAGACGCTGCTGCAGGAATAC
CTGCAGGGCCACAAGATCGCGCTGCCGACGTATACCGTCGTCGCGACGCATGGTGCGGCGCACAATCAGCAGTTCGAAGT
GGAATGCACGGTGCCGAAGCTCGACGTGAAGGTGTCGGGTTCCGGCGCGAGCCGCCGCGCGGCCGAGCAGGCCGCCGCGA
AGAAGGCGCTCGACGAGGTGATGGCGGCCGCGCCGATGCTGGCGGCGAAGCCGAAGCGCTCGAAGAGCGCGCGCGCGGCC
AAGCAGGCCGAGCCCGAGATCGTGCCGGGCGTGAAGGGCGTGCAGGAAGCGCTCGATCTGCGTTCGCCGGAGCGCAAGGA
GCGCGCGGCTGCGCGCGACGCGAAGGCTGCAGCGGCAGCTGCCGCTGCGGGCGCGGAGCCGGCCGAGCGGCCGGCCGTCG
CTCCCGTTGCCGCGATTCGCGCGGCGCATGTCGAAACCGCGGCCGACAAGGGCGAGCGCGCCGCAAAATCCGCGGCGGAC
AAGCCGGCGGCCGAAAAAGCGCCCGATCGCGCCGACGGCGCATCGCGTGCGGCCGACAAGCCTGCCGACAAGCCGGCCGG
CGCCGCGTCGGACGCCTCGACGGCTTCCGGCGATACGGCATCGCGCCCCGACAAGTCGGCGGCCGCCGATGCCCGCACCG
CGGCGCGCGTGCCAGACGTCGCCGCTGCCGGCCCCGATACGTCGGCCGGCGCCGCGAGCGTGGCCGCCGCGCCGGCGCGC
GTCGCCGATGCCGACCACTGA

Upstream 100 bases:

>100_bases
GAACTACTTTAAAAACCGGCGGTAACACCGCTTCGTCACGCCTTTTCGCGTCCGGCCGCGCCGTTTCGGCCCGAACGGCG
CCCGCGTTATACTCCTGCAC

Downstream 100 bases:

>100_bases
ATTGCCCATCGATCGCGCCGCGCACCGCGCGGCCGGTTCCGAACCTGTCTCCCAATCGATATGAACGCTCCCGCTCCTAC
TGGTTTCCGCTGCGGCATGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISEGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKSARAA
KQAEPEIVPGVKGVQEALDLRSPERKERAAARDAKAAAAAAAAGAEPAERPAVAPVAAIRAAHVETAADKGERAAKSAAD
KPAAEKAPDRADGASRAADKPADKPAGAASDASTASGDTASRPDKSAAADARTAARVPDVAAAGPDTSAGAASVAAAPAR
VADADH

Sequences:

>Translated_406_residues
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISEGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKSARAA
KQAEPEIVPGVKGVQEALDLRSPERKERAAARDAKAAAAAAAAGAEPAERPAVAPVAAIRAAHVETAADKGERAAKSAAD
KPAAEKAPDRADGASRAADKPADKPAGAASDASTASGDTASRPDKSAAADARTAARVPDVAAAGPDTSAGAASVAAAPAR
VADADH
>Mature_405_residues
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYEI
AQALNISEGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKSARAAK
QAEPEIVPGVKGVQEALDLRSPERKERAAARDAKAAAAAAAAGAEPAERPAVAPVAAIRAAHVETAADKGERAAKSAADK
PAAEKAPDRADGASRAADKPADKPAGAASDASTASGDTASRPDKSAAADARTAARVPDVAAAGPDTSAGAASVAAAPARV
ADADH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=27.3127753303965, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=27.3127753303965, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788920, Length=204, Percent_Identity=52.9411764705882, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=31.9796954314721, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=31.9796954314721, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=35.0515463917526, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137682, Length=256, Percent_Identity=27.734375, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 42246; Mature: 42115

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCCEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKSARAA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KQAEPEIVPGVKGVQEALDLRSPERKERAAARDAKAAAAAAAAGAEPAERPAVAPVAAIR
HHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AAHVETAADKGERAAKSAADKPAAEKAPDRADGASRAADKPADKPAGAASDASTASGDTA
HHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCC
SRPDKSAAADARTAARVPDVAAAGPDTSAGAASVAAAPARVADADH
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHCCCCC
>Mature Secondary Structure 
PLSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISEGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYVPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCCEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKSARAA
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KQAEPEIVPGVKGVQEALDLRSPERKERAAARDAKAAAAAAAAGAEPAERPAVAPVAAIR
HHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
AAHVETAADKGERAAKSAADKPAAEKAPDRADGASRAADKPADKPAGAASDASTASGDTA
HHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCC
SRPDKSAAADARTAARVPDVAAAGPDTSAGAASVAAAPARVADADH
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]