Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 161525334

GI number: 161525334

Start: 2380703

End: 2382088

Strand: Direct

Name: atoC [H]

Synonym: Bmul_2164

Alternate gene names: 161525334

Gene position: 2380703-2382088 (Clockwise)

Preceding gene: 161525333

Following gene: 161525357

Centisome position: 69.04

GC content: 69.55

Gene sequence:

>1386_bases
ATGCCACACGCCCTGATTGTCGAAGACGATCCCAACAGCCTGTCCGGCCTCACCGCGCTGCTCGCCGCGGACGGTTTCTC
CGTCGACACGGCCACGTCGCTCGCCGAAGCGCGCACCGCGCTCGGCCGATCGATCCCCGACGTCGTCCTGGTCGATCTGA
ACCTGCCGGACGGCAGCGGGTTCGACCTGCTCCAGCACCTGCCGCAACAGCAACCGAACGGGTCCTTACCCGTGATCGTG
CTGACCGGCAACGCGACGGTCGAAAGCGCGATCGAGGGTCTGCGTCACGGCATCTGGGACTATCTGCTCAAGCCGATCAA
CATCCCGCGCCTGCGCAGCCTGCTCGCGCGGATTCCGCGCCCGTACGAACTGATCGACGAAGTGCAGTCGCTGCGCACGT
CGCTGCGTCAGCTCGGCCGCTTCGGCGCGCTGGTCGGGCGCAGCGAGGCGATGCAGCACGTGTACGACATGATCGAGCAC
AACGCGCGCACCGAAACGGCCGTGCTGTTCTCCGGCGAAGCGGGCACCGGCAAGAAGCTCGCCGCGCGCACGCTGCACGA
TCTGAGCCGCCGCCGCAAGGGGCCGTTCGTCTCGTTCGACTGCCGCACGCTCGCCCAGGCCGGCCGCCACGGCGCGTCGC
TCGACAGCGTGCTGTTCGGCCACGAGCGCGGCGCGTTCGACGGCGCCGACCGGCGCGAGGTGGGCCTGTTCGAACAGGCG
GGCGGCGGCACGCTGTTCCTCGACGAAATCACCGCGCTGCCGCTGGTGCTGCAGGAAGCGCTGCTGCACGCGCTCGACTC
GCAGAACTTCATGCGGATCGGCGGCACGAGCACGATCGCGAGCGATTTCCGGCTGATCGCGGCGACGCGCCGCCCGGCAC
GCGAAGCGGTCGCGAACGGCACGCTGCGCGAGGATCTGTGGCTGCGTCTCGATGCGGCGTCGATCACGATGCCGCCGCTG
CGCGAACGCGACGGCGACGCGCTCGCGATCGCCGACGCGCTGATCGACCAGTTGAACCGCGACGCGCATGCGACGGGCCG
CGGCACGACCGACAAGCGCGCGGCGCCCGGTTTCGTGCGCGAATGTCTGTCGTACGAATGGCCCGGCAACGTGCGCGAGC
TGCAGGAGCGCGTGCGCTTCGCCTACGACGCGTCCGGCGATTTCATCGAAACGCTGCGCGCCGGCGAAGCGAGCTTTGCG
GCCGGCGCCGCGCTGAACGGCAGCAGCGTGCAGATCAAGGTCGGCACGCCGCTGTCGGACGTCGAGGACCTGCTGATCCG
CGCGACGCTCGATGCGGTCGGCGGCACGCGCCACCGCGCGGCGACGCTGCTCGGCATCAGCCCGAAGACGCTGTACAACA
AGCTGCAGCGAATGAAGGTGAATTGA

Upstream 100 bases:

>100_bases
TGACGCGTGCAGCGGGGCATAAAATCGGCTTTTAATCTCATCTCGAAATGCGGCTGCGGATTGACGGCCCGCCTCTCTTG
AACCGACTCTCGCGTCCACC

Downstream 100 bases:

>100_bases
GTTGAACCGGCGTTCCTTTTGGGCGCCGGCGGGGCTGGCCGTTAGTTGCAAACACAGCCGATTCAGTTGCTCTCATTGAA
AGAGCGCTTTGAGCGAAAAG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRTSLRQLGRFGALVGRSEAMQHVYDMIEH
NARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRTLAQAGRHGASLDSVLFGHERGAFDGADRREVGLFEQA
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSTIASDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPL
RERDGDALAIADALIDQLNRDAHATGRGTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFA
AGAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN

Sequences:

>Translated_461_residues
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIV
LTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRTSLRQLGRFGALVGRSEAMQHVYDMIEH
NARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRTLAQAGRHGASLDSVLFGHERGAFDGADRREVGLFEQA
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSTIASDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPL
RERDGDALAIADALIDQLNRDAHATGRGTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFA
AGAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
>Mature_460_residues
PHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSGFDLLQHLPQQQPNGSLPVIVL
TGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPRPYELIDEVQSLRTSLRQLGRFGALVGRSEAMQHVYDMIEHN
ARTETAVLFSGEAGTGKKLAARTLHDLSRRRKGPFVSFDCRTLAQAGRHGASLDSVLFGHERGAFDGADRREVGLFEQAG
GGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSTIASDFRLIAATRRPAREAVANGTLREDLWLRLDAASITMPPLR
ERDGDALAIADALIDQLNRDAHATGRGTTDKRAAPGFVRECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFAA
GAALNGSSVQIKVGTPLSDVEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=35.2813852813853, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=35.589519650655, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1790299, Length=477, Percent_Identity=32.4947589098532, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1788905, Length=373, Percent_Identity=34.5844504021448, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1789087, Length=259, Percent_Identity=41.6988416988417, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789233, Length=334, Percent_Identity=33.2335329341317, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87082117, Length=339, Percent_Identity=35.693215339233, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081872, Length=331, Percent_Identity=33.8368580060423, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1786524, Length=343, Percent_Identity=33.5276967930029, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87082152, Length=238, Percent_Identity=37.8151260504202, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787583, Length=238, Percent_Identity=31.0924369747899, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1789828, Length=236, Percent_Identity=37.2881355932203, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI87081858, Length=301, Percent_Identity=27.906976744186, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786599, Length=132, Percent_Identity=31.0606060606061, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786838, Length=132, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790552, Length=117, Percent_Identity=36.7521367521368, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787229, Length=249, Percent_Identity=28.9156626506024, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49886; Mature: 49755

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSG
CCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
FDLLQHLPQQQPNGSLPVIVLTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIDEVQSLRTSLRQLGRFGALVGRSEAMQHVYDMIEHNARTETAVLFSGEAGTGKKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHDLSRRRKGPFVSFDCRTLAQAGRHGASLDSVLFGHERGAFDGADRREVGLFEQA
HHHHHHHHHHHCCCCEEEECHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEC
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSTIASDFRLIAATRRPAREAVANG
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHCC
TLREDLWLRLDAASITMPPLRERDGDALAIADALIDQLNRDAHATGRGTTDKRAAPGFVR
CHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
ECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFAAGAALNGSSVQIKVGTPLSD
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCCEECCCEEEEEECCCHHH
VEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
HHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHALIVEDDPNSLSGLTALLAADGFSVDTATSLAEARTALGRSIPDVVLVDLNLPDGSG
CCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
FDLLQHLPQQQPNGSLPVIVLTGNATVESAIEGLRHGIWDYLLKPINIPRLRSLLARIPR
HHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELIDEVQSLRTSLRQLGRFGALVGRSEAMQHVYDMIEHNARTETAVLFSGEAGTGKKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHH
AARTLHDLSRRRKGPFVSFDCRTLAQAGRHGASLDSVLFGHERGAFDGADRREVGLFEQA
HHHHHHHHHHHCCCCEEEECHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEC
GGGTLFLDEITALPLVLQEALLHALDSQNFMRIGGTSTIASDFRLIAATRRPAREAVANG
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHCC
TLREDLWLRLDAASITMPPLRERDGDALAIADALIDQLNRDAHATGRGTTDKRAAPGFVR
CHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
ECLSYEWPGNVRELQERVRFAYDASGDFIETLRAGEASFAAGAALNGSSVQIKVGTPLSD
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCCEECCCEEEEEECCCHHH
VEDLLIRATLDAVGGTRHRAATLLGISPKTLYNKLQRMKVN
HHHHHHHHHHHHHCCCHHHHEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]