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The map label for this gene is proY [H]

Identifier: 161525261

GI number: 161525261

Start: 2295813

End: 2297180

Strand: Direct

Name: proY [H]

Synonym: Bmul_2091

Alternate gene names: 161525261

Gene position: 2295813-2297180 (Clockwise)

Preceding gene: 161525260

Following gene: 161525263

Centisome position: 66.57

GC content: 66.45

Gene sequence:

>1368_bases
ATGAAGAATCTGCAGCGCCACCTGAGCGCGCGGCACATCCGCTTTCTCGCGCTGGGTTCGGCGATCGGCACCGGTCTGTT
CTACGGCTCGGCGTCCGCGATCCAGCTCGCGGGCCCGGCCGTGATCCTGGCGTACATCCTCGGCGGCGCGGCCGTCTACA
TGGTGATGCGCGCGCTCGGCGAGATGGCCGTGCGCGACCCGGTCGCCGGATCGTTCGGCCACTACGCGACCGAGAATCTC
GGGCCGTTTGCAGGCTTCGTCACCGGCTGGACCTACACGCTCGAAATGGTGATCGTCGCAATCGCCGACATCACCGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCCGGCGTCCCGCAGTGGATCTGGGTGCTCGGCGTCGTGGCCGTGATCTGCGGGC
TGAACCTCTGCCACGTGAAGGTATTCGGCGAACTCGAATTCTGGCTGTCGATCATCAAGGTCGGTGCGATCGTCGCGATG
ATCGGCGGCGGCGTCGCGATCCTGCTCGCCGGCATGCATTTCGGCCATTCGGCCGACGCGCCGAGCTTCGCGAATCTGTG
GAACCACGGCGGCTTCCTGCCGAACGGCATCGGCGGGTTGATCGCGTCGCTGTCGGTCGTGATCTTCGCGTACGGCGGCA
TCGAGGTGATCGGCATGAGCGCCGGCGAGGCCAAGGATCCGGAGCGCGTGATCCCGCGCGCGATCAACGCTGTGCCCGCG
CGGATCCTGCTGTTCTACGTGCTGACGATGGTCGTGCTGATGTCGATCAGCCCGTGGACCGGCGTCGGCAGCGAAGGCAG
CCCGTTCGTGCAGATCTTCTCGACGCTCGGCGTGAAGTCGGCCGCGACGATCCTCAACCTCGTCGTGATCAGCGCGGCGA
TCTCGGCGATCAACAGCGACATCTTCGGCGCGGGCCGGATGATGTTCGGCATGGCGCGGCAAGGCCAGGCGCCGCGCGTG
CTGACGAAGACGTCGCGGCACGGCGTGCCGTGGGTCACGGTGCTCGTGATGGCCGGTGCCTTGCTGATCGGCGTGCTGCT
CAACTACCTGATGCCGAAGGACGTGTTTCTGATGGTGGCCGCGATCGCGACGTTCGCGACCGTATGGGTCTGGCTCATGA
TCCTGCTGTCGCAGGTCGCGATGCGCCGTCGCCTGTCGGCCGCGGAAGTCGCGGCGCTGAAGTTCAAGGTGCCGCTGTGG
CCGGTCGCGCCCGCGCTGACGATCGCCTTCATGGCCTTCGTGATCGTGATGCTCGGCTGGTTCGACGATACGCGCGTGGC
GCTCTACGTCGGCGCGATCTGGCTCGCGTTGCTCGCGGCCGTGTTCTACGTGCGGATTCGTCCGCGTTTCGCGGCCGCGT
CACGTTGA

Upstream 100 bases:

>100_bases
GTCCACGCTTGTTATCATTCGTTCACATTCAAGTTGTATATACAACTCGACCTGGCGAGCCACCGCGCCCGCTCGGTCGG
ACAACGATTTCGGAGACTCG

Downstream 100 bases:

>100_bases
CGCACCGCTGATACCGCCATGCGGCGCGCCGGTTCCGGCGCCCCGCCCGCGCGGTGCCGCATCGCCCGAGCGGCGTTGCG
GCACCGCCGCTCCTCTTCTT

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPGVPQWIWVLGVVAVICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLAGMHFGHSADAPSFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSEGSPFVQIFSTLGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LTKTSRHGVPWVTVLVMAGALLIGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAEVAALKFKVPLW
PVAPALTIAFMAFVIVMLGWFDDTRVALYVGAIWLALLAAVFYVRIRPRFAAASR

Sequences:

>Translated_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPGVPQWIWVLGVVAVICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLAGMHFGHSADAPSFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSEGSPFVQIFSTLGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LTKTSRHGVPWVTVLVMAGALLIGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAEVAALKFKVPLW
PVAPALTIAFMAFVIVMLGWFDDTRVALYVGAIWLALLAAVFYVRIRPRFAAASR
>Mature_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPGVPQWIWVLGVVAVICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLAGMHFGHSADAPSFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSEGSPFVQIFSTLGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LTKTSRHGVPWVTVLVMAGALLIGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSAAEVAALKFKVPLW
PVAPALTIAFMAFVIVMLGWFDDTRVALYVGAIWLALLAAVFYVRIRPRFAAASR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=358, Percent_Identity=25.9776536312849, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI110347453, Length=334, Percent_Identity=26.9461077844311, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786602, Length=438, Percent_Identity=60.958904109589, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=44.0449438202247, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=437, Percent_Identity=43.9359267734554, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790653, Length=437, Percent_Identity=40.7322654462243, Blast_Score=354, Evalue=7e-99,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=41.978021978022, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=38.3084577114428, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI87081708, Length=451, Percent_Identity=34.8115299334812, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=36.319612590799, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=34.7222222222222, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=25.7731958762887, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082023, Length=193, Percent_Identity=27.979274611399, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=418, Percent_Identity=25.1196172248804, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=362, Percent_Identity=25.9668508287293, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532491, Length=423, Percent_Identity=24.3498817966903, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324061, Length=464, Percent_Identity=31.6810344827586, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=31.0502283105023, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=34.0966921119593, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=411, Percent_Identity=31.8734793187348, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=425, Percent_Identity=30.5882352941176, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=29.5454545454545, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=29.683698296837, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=27.8325123152709, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=434, Percent_Identity=25.8064516129032, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=25.9615384615385, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=26.448362720403, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=396, Percent_Identity=27.2727272727273, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=27.4809160305344, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=25.9953161592506, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=407, Percent_Identity=26.5356265356265, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=28.1012658227848, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=356, Percent_Identity=28.9325842696629, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=500, Percent_Identity=22.4, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667468, Length=332, Percent_Identity=26.5060240963855, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077963, Length=353, Percent_Identity=24.0793201133144, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48579; Mature: 48579

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPGVPQ
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WIWVLGVVAVICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLAGMHFGHSADA
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
PSFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGSEGSPFVQIFSTLGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLTKTSRHGVPWVTVLVMAGALLIGVLLNYLMPKDVFLMVA
HHHCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSAAEVAALKFKVPLWPVAPALTIAFMAFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHC
FDDTRVALYVGAIWLALLAAVFYVRIRPRFAAASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
>Mature Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPGVPQ
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WIWVLGVVAVICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLAGMHFGHSADA
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
PSFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGSEGSPFVQIFSTLGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLTKTSRHGVPWVTVLVMAGALLIGVLLNYLMPKDVFLMVA
HHHCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSAAEVAALKFKVPLWPVAPALTIAFMAFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHC
FDDTRVALYVGAIWLALLAAVFYVRIRPRFAAASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]