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The map label for this gene is aphA [H]

Identifier: 161525232

GI number: 161525232

Start: 2254888

End: 2255910

Strand: Reverse

Name: aphA [H]

Synonym: Bmul_2062

Alternate gene names: 161525232

Gene position: 2255910-2254888 (Counterclockwise)

Preceding gene: 161525233

Following gene: 161525228

Centisome position: 65.42

GC content: 70.09

Gene sequence:

>1023_bases
ATGAAGACGTATTTCCATCCCGAGCAATTGCTGCACCATCCGCGCACCTATCTGTCGCGCGGGCAGATGCGCGCGCCGCA
GGAAGTGCCGGAGCGCGCGGCGCGCCTGGTCGCGGCCGTGCGCGCACTCGACTTCGACGTGCGCGAGCCGGCCGACCGCG
GCACGGCGCCGATCGCGGCCGTGCACGACATGAATTACCTGCGCTTTCTCGAGGACGCGCACCGCGACTGGAAGAAGATG
CCCGACGACTGGGGCGACGAAGTGATGTCGAACATCTTCGTGCGCGATCCGAATCCGCTGCGCGGCGTGCTCGCGAAAGC
CGCGCGCTATCTCGCGGACGGCAGCTGCCCGATCGGTGCGAATACGTGGCGGGCCGCCTACTGGTCCGCGCAGAGCGCGC
TCGCGGCTGCGGCCGACGTGAACGACGGCGCGCGCGACGCGTATGCGCTGTGCCGGCCGCCCGGCCATCACGCGCGCCGC
GATGCGGCGGGCGGCTTCTGCTATCTGAACAACGCGGCGATTGCCGCGCAGGCGCTGCTCGGCCGCCATCGGCGCGTCGC
GATCCTCGACACCGACATGCATCACGGGCAGGGCGTGCAGGAAATCTTCTACGGCCGCGACGACGTGCTCTACGTGTCGA
TTCACGGCGATCCGACCGACTTCTATCCGGTCGTCGCGGGCTACGAGGACGAAACGGGCGCCGGTGCCGGCGCGGGCTAC
AACCTGAACCTGCCGATGCCGCACGGTTCGCAGGAGCCGGTGTTCTTCGAGCGCCTCGACGACGCACTGCGCGCGCTCGC
GCGCTTCGAGCCCGACGCGCTCGTGCTCGCGCTCGGCTTCGACATCTACAAGGACGATCCGCAGTCGCAGGTCGCGGTGA
CGACCGACGGCTTCGGCCGGCTCGGCAGCGCGATCGGCGCGCTCGGTCTGCCGACCGTGATCGTGCAGGAAGGCGGCTAT
CACCTCGCCAGCCTCGACGCGAACGCGCGCGCGTTCTTCGGCGGCTTCGGCGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
CTGCTGCACGCGGTGCTTGCGCGGGCGGGCGTCGCGGCGTGTGCGGACGCCGCGGCAGCCGCGCCGCGCGCATGACGATG
CATTTCGACGAGGACGATCG

Downstream 100 bases:

>100_bases
GCGTGCAGGCGGCCGGTGCGTGAAGCAGGCGCGGGGCCGATGACGACGCGACACGGGCCGGATGACCGACCCGTGTGCGT
TGGTGCGCCTGATCGAATTC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKTYFHPEQLLHHPRTYLSRGQMRAPQEVPERAARLVAAVRALDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKKM
PDDWGDEVMSNIFVRDPNPLRGVLAKAARYLADGSCPIGANTWRAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTDFYPVVAGYEDETGAGAGAGY
NLNLPMPHGSQEPVFFERLDDALRALARFEPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGSAIGALGLPTVIVQEGGY
HLASLDANARAFFGGFGAAR

Sequences:

>Translated_340_residues
MKTYFHPEQLLHHPRTYLSRGQMRAPQEVPERAARLVAAVRALDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKKM
PDDWGDEVMSNIFVRDPNPLRGVLAKAARYLADGSCPIGANTWRAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTDFYPVVAGYEDETGAGAGAGY
NLNLPMPHGSQEPVFFERLDDALRALARFEPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGSAIGALGLPTVIVQEGGY
HLASLDANARAFFGGFGAAR
>Mature_340_residues
MKTYFHPEQLLHHPRTYLSRGQMRAPQEVPERAARLVAAVRALDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKKM
PDDWGDEVMSNIFVRDPNPLRGVLAKAARYLADGSCPIGANTWRAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTDFYPVVAGYEDETGAGAGAGY
NLNLPMPHGSQEPVFFERLDDALRALARFEPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGSAIGALGLPTVIVQEGGY
HLASLDANARAFFGGFGAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI8923769, Length=311, Percent_Identity=26.6881028938907, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI13128864, Length=240, Percent_Identity=33.75, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI30795204, Length=213, Percent_Identity=32.8638497652582, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI30795202, Length=213, Percent_Identity=32.8638497652582, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI17158039, Length=227, Percent_Identity=32.15859030837, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI20070354, Length=213, Percent_Identity=37.0892018779343, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13128860, Length=233, Percent_Identity=28.755364806867, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI148539870, Length=213, Percent_Identity=34.2723004694836, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI169234807, Length=213, Percent_Identity=34.2723004694836, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI262073088, Length=180, Percent_Identity=35, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI153085395, Length=263, Percent_Identity=30.7984790874525, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI13128862, Length=225, Percent_Identity=28.4444444444444, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI62750347, Length=192, Percent_Identity=35.4166666666667, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI62750349, Length=192, Percent_Identity=35.4166666666667, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI293336691, Length=232, Percent_Identity=26.7241379310345, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI226529806, Length=216, Percent_Identity=34.2592592592593, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073092, Length=259, Percent_Identity=24.7104247104247, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=199, Percent_Identity=40.2010050251256, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17540332, Length=199, Percent_Identity=40.2010050251256, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206283, Length=199, Percent_Identity=40.2010050251256, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=311, Percent_Identity=28.6173633440514, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17561978, Length=236, Percent_Identity=30.5084745762712, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17534739, Length=212, Percent_Identity=30.6603773584906, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537347, Length=226, Percent_Identity=32.3008849557522, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193209491, Length=222, Percent_Identity=31.5315315315315, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25154022, Length=198, Percent_Identity=28.2828282828283, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=198, Percent_Identity=28.2828282828283, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=206, Percent_Identity=37.8640776699029, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323999, Length=241, Percent_Identity=27.3858921161826, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321244, Length=208, Percent_Identity=29.3269230769231, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=149, Percent_Identity=26.8456375838926, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644244, Length=272, Percent_Identity=30.1470588235294, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI281360799, Length=259, Percent_Identity=33.5907335907336, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281360899, Length=241, Percent_Identity=34.8547717842324, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281360801, Length=259, Percent_Identity=33.5907335907336, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24641720, Length=259, Percent_Identity=33.5907335907336, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24642146, Length=241, Percent_Identity=34.8547717842324, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24642142, Length=241, Percent_Identity=34.8547717842324, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24642144, Length=243, Percent_Identity=34.5679012345679, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24657891, Length=236, Percent_Identity=30.0847457627119, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37058; Mature: 37058

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYFHPEQLLHHPRTYLSRGQMRAPQEVPERAARLVAAVRALDFDVREPADRGTAPIAA
CCCCCCHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEH
VHDMNYLRFLEDAHRDWKKMPDDWGDEVMSNIFVRDPNPLRGVLAKAARYLADGSCPIGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTDFYPVVAGYEDETGAGAGAGY
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCE
NLNLPMPHGSQEPVFFERLDDALRALARFEPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCHHH
LGSAIGALGLPTVIVQEGGYHLASLDANARAFFGGFGAAR
HHHHHHHCCCCEEEEECCCEEEEECCCCCCEEECCCCCCC
>Mature Secondary Structure
MKTYFHPEQLLHHPRTYLSRGQMRAPQEVPERAARLVAAVRALDFDVREPADRGTAPIAA
CCCCCCHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEH
VHDMNYLRFLEDAHRDWKKMPDDWGDEVMSNIFVRDPNPLRGVLAKAARYLADGSCPIGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTDFYPVVAGYEDETGAGAGAGY
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCE
NLNLPMPHGSQEPVFFERLDDALRALARFEPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCHHH
LGSAIGALGLPTVIVQEGGYHLASLDANARAFFGGFGAAR
HHHHHHHCCCCEEEEECCCEEEEECCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]