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The map label for this gene is fsr [H]

Identifier: 161525043

GI number: 161525043

Start: 2042142

End: 2043383

Strand: Direct

Name: fsr [H]

Synonym: Bmul_1871

Alternate gene names: 161525043

Gene position: 2042142-2043383 (Clockwise)

Preceding gene: 161525041

Following gene: 161525046

Centisome position: 59.22

GC content: 67.23

Gene sequence:

>1242_bases
ATGGAAACCAGCCTCGACACGGGCACGGCCGGCGCAGCCGCCGCGGCCCAGACGTCTGCTCCGCCTGCGCCGCGCACCGT
CTATCCGGTGCTCGGCGCGATCAGCTTCTCGCACATGCTCAACGACATGATCCAGTCGTTGATCCTCGCGATCTATCCGA
TGCTCAAGAGCCAGTTCGCGCTGTCGTTCGCGCAGATCGGGCTGATCACGCTCACCTACCAGATCACCGCGTCGCTGCTG
CAGCCGCTCGTCGGCCTCTACACGGACAAGCGGCCGAAGCCGTACTCGCTGCCGGTCGGGATGGGCTTCACGCTGTCGGG
CCTGCTGCTGATGTCGGTCGCGCCGAACTTCCCGATGCTGCTCGTCGCGGCCGCGCTCGTCGGCTGCGGCTCGTCGGTGT
TCCATCCGGAATCGTCGCGCGTCGCGCGCATGGCATCGGGCGGCCGGCACGGCCTCGCGCAGTCGCTGTTCCAGGTCGGC
GGCAATGCGGGCTCGGCGCTCGGGCCGCTGCTCGCCGCGCTCGTGATCATTCCGCACGGCCAGCACAGCATCGCGTGGTT
CTCGGCCGCCGCGCTCGTCGCGATGGTCGTGCTGACGCAGATCGGCCACTGGTACAAGAAGCATCCGTCGATGAAGAAGA
AGGCGGCGGCCGCCGGCCATCCGACGCTGTCGCGCGGCCGCGTGCTCGGCGCGATCGGCGTGCTCGTGCTGCTCGTGTTC
TCGAAGTATTTCTATCTGGCGAGCATCAACAGCTACTTCACGTTCTATCTGATCGACAAGTTCCATCTGTCGGTGCAGGC
CGCGCAGATCCACCTGTTCGTGTTCCTCGCGGCCGTCGCGGCCGGCACGCTGATCGGCGGGCCGGTCGGCGACCGGATCG
GCCGCAAGTACGTGATCTGGGTCTCGATTCTCGGCGTCGCGCCGTTCACGCTGCTGCTGCCGTACGCGAACCTGTTCTGG
ACCGGCGTGCTGAGCGTGATCATCGGCGTCGTGCTCGCGTCGGCGTTCGCGGCGATTCTCGTCTATGCGACCGAGCTGAT
GCCCGGCAAGGTCGGGATGGTCGCGGGGCTGTTCTTCGGCTTCGCGTTCGGTCTTGGCGGCGTGGGCGCGGCCGTGCTCG
GTCAGCTCGCCGATGCGACCAGCATCCCGTTCGTCTACAAGGTGTGCTCGTTCCTGCCGCTGATCGGCGTGCTGACGGTG
TTCCTGCCGAATCTCGAAGGCAGCCGCCGCAAGACGGCCTGA

Upstream 100 bases:

>100_bases
ATTCTCGATGCGCCACATTACACTCCTTTGACGCAACAACGATTCGAACGCGCGGATCCCCGTCCAAGCGCGCCCTGCTA
CCTCAATTCGCTCAGCTCAC

Downstream 100 bases:

>100_bases
CGATGCGGCCGCCGCCCGCGCGCGGCGGCCGGGCCGATGAAAAAAACCGGAAACGACGGCGGCTTCAGGCCGCCGTCGTC
GCGTGCAGCGTCAGGAAGCG

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
METSLDTGTAGAAAAAQTSAPPAPRTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPKPYSLPVGMGFTLSGLLLMSVAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVG
GNAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMVVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVLGAIGVLVLLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFW
TGVLSVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTV
FLPNLEGSRRKTA

Sequences:

>Translated_413_residues
METSLDTGTAGAAAAAQTSAPPAPRTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPKPYSLPVGMGFTLSGLLLMSVAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVG
GNAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMVVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVLGAIGVLVLLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFW
TGVLSVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTV
FLPNLEGSRRKTA
>Mature_413_residues
METSLDTGTAGAAAAAQTSAPPAPRTVYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLL
QPLVGLYTDKRPKPYSLPVGMGFTLSGLLLMSVAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVG
GNAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMVVLTQIGHWYKKHPSMKKKAAAAGHPTLSRGRVLGAIGVLVLLVF
SKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTLLLPYANLFW
TGVLSVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTV
FLPNLEGSRRKTA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=413, Percent_Identity=65.8595641646489, Blast_Score=499, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43343; Mature: 43343

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]