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The map label for this gene is ghrB [H]

Identifier: 161524701

GI number: 161524701

Start: 1685447

End: 1686412

Strand: Direct

Name: ghrB [H]

Synonym: Bmul_1528

Alternate gene names: 161524701

Gene position: 1685447-1686412 (Clockwise)

Preceding gene: 161524700

Following gene: 161524702

Centisome position: 48.88

GC content: 70.39

Gene sequence:

>966_bases
ATGAAGCCTCGTATCGTCGCGTACAAGCCGCTGCCCGATGACGTCCTCGCGTATCTGCGCGAGCATGCGGACGTCGTGCA
GGCCGACGGCGCCGACGCGCTGGCCGATGCGCTCGGCGATGCCGACGGCGCAATCGGCGCGAGCCTGAAGATCACGCCGC
AGATGCTCGATCGCGCGCCGCGCCTGAAGGCGTGGTCGACGATTTCGGTCGGCTACGACAACTTCGACGTCGCCGATCTG
ACGCGGCGCGGCATCGTGCTCGCGCACACGCCCGACGTGCTGACTGAGTCGACCGCCGATACCGTGTTCTCGCTGATCCT
GGCCTCCGCGCGGCGCGTCGTCGAACTCGCCGAGTGGGTGAAGGCCGGCCACTGGCATCGCAGCATCGGCCCCGAGCTCT
ACGGCACCGACGTGCAGGGCAAGACGCTCGGCATCGTCGGGCTCGGGCGCATCGGCGGCGCCGTCGCGCGGCGTGCGGCG
CTCGGCTTCCGGATGCAGGTGCTGTACACGAACCGCGCCGCGCATCCGGAAGCGGAGACGCAATACGGCGCGCGGCGCGT
GACGCTCGACACGCTGCTCGCGCAGTCGGATTTCGTCTGCCTGCAGGTGCCGCTGTCGCCGGAGACGCGTCACCTGATCG
GCGCCGCCGAATTCGCGAAGATGAAGCGCAGCGCGATCCTGATCAACGCGTCGCGCGGGCCGGTCGTCGACGAGGCCGCG
CTGATCGACGCGCTGCGCGCCGGCACGATCCGCGGCGCAGGGCTCGACGTGTTCGAGAAGGAACCGCTGTCGGCCGATTC
GCCGCTGCTGCAGATGCGCAACGTCGTCGCGCTGCCGCACATCGGTTCGGCGACGCACGAGACGCGTCATGCGATGGCGC
GCTGCGCGGCGGAAAACCTGGTCGGCGCGCTGGCCGGCACGCTGCGCTCGAACCTTGTCAATCCGGACGCGCTCGCGCCG
CGCTGA

Upstream 100 bases:

>100_bases
GAGCGCCGCGCTCGTCGCCGCCGTGATCCTGACGCTGTCCGTCAAACCCCAGCCGCGCGACGCCCATTCGCTCGCGGCGC
CGCTGCAAGGAAAATGAAAG

Downstream 100 bases:

>100_bases
GGCGCCAAGGCGCTGAGGCACGGCCGCGCCGGGGGCGGCTGGCCGGCCGCATGCCTGCCGTTAGAATCGACGGTCTTGGT
GCCGGTGGGCGGCGTGCGTT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKPRIVAYKPLPDDVLAYLREHADVVQADGADALADALGDADGAIGASLKITPQMLDRAPRLKAWSTISVGYDNFDVADL
TRRGIVLAHTPDVLTESTADTVFSLILASARRVVELAEWVKAGHWHRSIGPELYGTDVQGKTLGIVGLGRIGGAVARRAA
LGFRMQVLYTNRAAHPEAETQYGARRVTLDTLLAQSDFVCLQVPLSPETRHLIGAAEFAKMKRSAILINASRGPVVDEAA
LIDALRAGTIRGAGLDVFEKEPLSADSPLLQMRNVVALPHIGSATHETRHAMARCAAENLVGALAGTLRSNLVNPDALAP
R

Sequences:

>Translated_321_residues
MKPRIVAYKPLPDDVLAYLREHADVVQADGADALADALGDADGAIGASLKITPQMLDRAPRLKAWSTISVGYDNFDVADL
TRRGIVLAHTPDVLTESTADTVFSLILASARRVVELAEWVKAGHWHRSIGPELYGTDVQGKTLGIVGLGRIGGAVARRAA
LGFRMQVLYTNRAAHPEAETQYGARRVTLDTLLAQSDFVCLQVPLSPETRHLIGAAEFAKMKRSAILINASRGPVVDEAA
LIDALRAGTIRGAGLDVFEKEPLSADSPLLQMRNVVALPHIGSATHETRHAMARCAAENLVGALAGTLRSNLVNPDALAP
R
>Mature_321_residues
MKPRIVAYKPLPDDVLAYLREHADVVQADGADALADALGDADGAIGASLKITPQMLDRAPRLKAWSTISVGYDNFDVADL
TRRGIVLAHTPDVLTESTADTVFSLILASARRVVELAEWVKAGHWHRSIGPELYGTDVQGKTLGIVGLGRIGGAVARRAA
LGFRMQVLYTNRAAHPEAETQYGARRVTLDTLLAQSDFVCLQVPLSPETRHLIGAAEFAKMKRSAILINASRGPVVDEAA
LIDALRAGTIRGAGLDVFEKEPLSADSPLLQMRNVVALPHIGSATHETRHAMARCAAENLVGALAGTLRSNLVNPDALAP
R

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=45.3061224489796, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=34.020618556701, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI145580578, Length=285, Percent_Identity=35.4385964912281, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557499, Length=285, Percent_Identity=35.4385964912281, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI61743967, Length=290, Percent_Identity=35.8620689655172, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI4557497, Length=290, Percent_Identity=35.8620689655172, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=35.4609929078014, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=59.375, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=32.1705426356589, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787645, Length=192, Percent_Identity=31.25, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081824, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=308, Percent_Identity=31.8181818181818, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=284, Percent_Identity=28.5211267605634, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=41.2017167381974, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=262, Percent_Identity=35.4961832061069, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=277, Percent_Identity=34.6570397111913, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=178, Percent_Identity=30.8988764044944, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=178, Percent_Identity=29.7752808988764, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=179, Percent_Identity=30.1675977653631, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551003, Length=310, Percent_Identity=39.6774193548387, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24585514, Length=310, Percent_Identity=39.6774193548387, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574282, Length=310, Percent_Identity=39.6774193548387, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI45552429, Length=310, Percent_Identity=39.6774193548387, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574284, Length=310, Percent_Identity=39.6774193548387, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28571528, Length=278, Percent_Identity=43.1654676258993, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI28574286, Length=311, Percent_Identity=36.6559485530547, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=35.1778656126482, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921140, Length=299, Percent_Identity=34.4481605351171, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646446, Length=294, Percent_Identity=36.3945578231293, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=294, Percent_Identity=36.3945578231293, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=294, Percent_Identity=36.3945578231293, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=294, Percent_Identity=36.3945578231293, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=291, Percent_Identity=36.426116838488, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34280; Mature: 34280

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRIVAYKPLPDDVLAYLREHADVVQADGADALADALGDADGAIGASLKITPQMLDRAP
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECHHHHCCCC
RLKAWSTISVGYDNFDVADLTRRGIVLAHTPDVLTESTADTVFSLILASARRVVELAEWV
CCCCCEEEEECCCCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGHWHRSIGPELYGTDVQGKTLGIVGLGRIGGAVARRAALGFRMQVLYTNRAAHPEAET
HHCCCHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHH
QYGARRVTLDTLLAQSDFVCLQVPLSPETRHLIGAAEFAKMKRSAILINASRGPVVDEAA
HHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
LIDALRAGTIRGAGLDVFEKEPLSADSPLLQMRNVVALPHIGSATHETRHAMARCAAENL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHH
VGALAGTLRSNLVNPDALAPR
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKPRIVAYKPLPDDVLAYLREHADVVQADGADALADALGDADGAIGASLKITPQMLDRAP
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECHHHHCCCC
RLKAWSTISVGYDNFDVADLTRRGIVLAHTPDVLTESTADTVFSLILASARRVVELAEWV
CCCCCEEEEECCCCCCHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGHWHRSIGPELYGTDVQGKTLGIVGLGRIGGAVARRAALGFRMQVLYTNRAAHPEAET
HHCCCHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCEEEEEEEECCCCCCCHHH
QYGARRVTLDTLLAQSDFVCLQVPLSPETRHLIGAAEFAKMKRSAILINASRGPVVDEAA
HHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
LIDALRAGTIRGAGLDVFEKEPLSADSPLLQMRNVVALPHIGSATHETRHAMARCAAENL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHH
VGALAGTLRSNLVNPDALAPR
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA