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The map label for this gene is phbA [H]

Identifier: 161524657

GI number: 161524657

Start: 1635811

End: 1636992

Strand: Direct

Name: phbA [H]

Synonym: Bmul_1484

Alternate gene names: 161524657

Gene position: 1635811-1636992 (Clockwise)

Preceding gene: 161524656

Following gene: 161524658

Centisome position: 47.44

GC content: 69.37

Gene sequence:

>1182_bases
ATGACGGACGTAGTGATCGTATCGGCCGCGCGGACCGCGGTCGGCAAATTCGGCGGCTCGCTGGCGAAGGTGGCGGCGCC
CGAACTGGGCGCGACGGTGGTCCGCGCGGTGCTGGAGCGCGCGGGCGTGAAGCCGGACCAGGTCAGCGAAGTGATCATGG
GGCAGGTGCTGACGGCGGGTTCGGGCCAGAACCCGGCACGCCAGTCGCTGATCAAGGCCGGATTGCCGAGCGCGGTGCCG
GGGATGACGATCAACAAGGTGTGCGGCTCGGGGCTGAAGGCCGTGATGCTGGCCGCGAACGCGATCGTCGCGGGCGACGC
GGAGATCGTCGTGGCGGGCGGGCAGGAAAACATGAGCGCGGCGCCGCACGTGCTGCCGGGCTCGCGCGACGGGTTCCGGA
TGGGCGACGCGAAGCTGGTCGACACGATGATCGTCGACGGCCTCTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCGGAGAACGTCGCGAAGGAATACGGCATCACGCGCGAAGAGCAGGACGCGTTCGCGGCGCTGTCGCAGAACAAGGCCGA
AGCGGCGCAGAAGGCAGGGCGCTTCAATGACGAGATCGTGCCGGTGTCGATTCCGCAGCGCAAGGGCGAGCCGCTGCAGT
TCGCGACCGACGAGTTCGTGCGTCACGGCGTGACGGCGGAGTCGCTCGCGGGGCTGAAGCCGGCGTTCGCGAAGGACGGC
ACGGTGACGGCGGCCAACGCGTCGGGCATCAACGACGGCGCGGCGGCGGTGCTCGTGATGTCGGCGCAGAAGGCCCAGGC
GCTGGGCCTGACGCCGCTCGCGCGGATCAAGGCCTATGCGAACGCGGGCGTGGATCCGAGCGTGATGGGGATGGGCCCGG
TGCCGGCATCGCGTCGATGCCTGGAGCGTGCGGGCTGGACGCCAGGCGATCTGGATCTGATGGAGATCAACGAGGCGTTT
GCGGCGCAGGCGCTGGCGGTGCACAAGCAGATGGGCTGGGACACGTCGAAGGTGAACGTGAACGGCGGCGCGATCGCGAT
CGGTCATCCGATCGGCGCGTCGGGCTGCCGGATCCTGGTGACGCTGCTGCACGAGATGGTCAAGCGCGATGCGAAGCGCG
GGCTCGCGTCGCTCTGCATCGGCGGCGGGATGGGCGTCGCGCTGGCGGTCGAACGTCCGTAA

Upstream 100 bases:

>100_bases
CGAAAGCCGGACAGCGGCGCACGCTGTCCGACTGCACCGCAGTTTTTTTAACAGGGTCGGCAGCGACGCGCCGTGTCGCG
CGGGCTCGGAGGAATGGAAA

Downstream 100 bases:

>100_bases
CGGGCGAACCGTATCCCGGTGCCGGCCAGCCCAGCATCGGCCGGCGCCGTGTGAAGTCGGAGGGCGCTTCGGCGGCCCTC
GAAACCCAAAAATGGAGTGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVVRAVLERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVVRAVLERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKVAAPELGATVVRAVLERAGVKPDQVSEVIMGQVLTAGSGQNPARQSLIKAGLPSAVPG
MTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDGT
VTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWTPGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMVKRDAKRGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.5217391304348, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.6153846153846, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.2748091603053, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=42.713567839196, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.1320754716981, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=31.6455696202532, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=63.265306122449, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=61.0687022900763, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.5445544554455, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.6065162907268, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=33.7408312958435, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.9230769230769, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.3772609819121, Blast_Score=301, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.4141414141414, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.6530612244898, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.3084112149533, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=42.3173803526448, Blast_Score=288, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=40.6565656565657, Blast_Score=237, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.8877551020408, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.0559796437659, Blast_Score=324, Evalue=6e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=44.8717948717949, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=181, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40435; Mature: 40304

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKVAAPELGATVVRAVLERAGVKPDQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMVKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKVAAPELGATVVRAVLERAGVKPDQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPSAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFAKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVLVMSAQKAQALGLTPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMVKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]