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The map label for this gene is acoA [H]

Identifier: 161524607

GI number: 161524607

Start: 1578196

End: 1579179

Strand: Direct

Name: acoA [H]

Synonym: Bmul_1434

Alternate gene names: 161524607

Gene position: 1578196-1579179 (Clockwise)

Preceding gene: 161524606

Following gene: 161524608

Centisome position: 45.77

GC content: 67.89

Gene sequence:

>984_bases
ATGTCCGTTTCGACACAGCTCAGCAGGGACACGCTGCTGGAGGCATACCGGCTGATGCGCACGATTCGCGAATTCGAGGA
GCGCCTGCACGTCGAGTTCGCGACCGGCGAGATTCCCGGCTTCGTTCACCTGTATGCGGGCGAGGAGGCGTCCGCGGTCG
GCACGATGCTGCACCTCGGCGTTGCCGACTACGTCGCGACGACGCACCGCGGCCACGGCCACTGCATCGCGAAGGGCGTC
GACGTGCGCGGGATGATGGCCGAGATCTACGGGAAGAAGACCGGCGTCTGTCACGGCAAGGGCGGCTCGATGCACATCGC
CGACCTGTCGATGGGGATGCTCGGCGCGAACGGGATCGTCGGGGCGGGCGGGCCGCTCGTCTGCGGCGCGGCGCTCGCGG
CCAAGCAGAAGAAGACAGGCGGCGTCGGCGTCTGCTTCTTCGGCGACGGCGCATCGAACCAGGGCGTGATCTTCGAATCG
ATGAACCTCGCGTCGGTGTGGCGGCTGCCCGCGATCTTCGTCGCCGAGAACAACGGCTACGCGGAAGCGACCTCGTCGAG
CTGGTCGGTCGCGACCGACAACATCGCCGATCGCGCGAACGGCTTCGGCATGCCGGGCGTGATCGTCGACGGCTTCGACT
TCTTCGCCGTGCACGAGGCGCTCGGCGAAGCCGTCGAGCGCGCGCGCAACGGCGGCGGCCCGACGCTCGTCGAGGTGAAG
TTCTCGCGCTACTTCGGCCACTTCGAAGGCGACGCGCAAACCTATCGCGCGCCCGGCGAAGTACAGAAGCTGCGCGACGA
GAAGGACTGCCTGAAGCATTTCGAAGCGCGCGTCGTGCGCGCCGAAGTGCTGACGACGGACGAGCTGCGTGCGGTCGACG
CGCAGGTGAAGGCGCTGATCGACGACGCGGTGGCCGAAGCGAAGGCCGCGCCGCTGCCGGATGCGGCCGACCTGCTGACC
GACGTCTACGTGTCGTATCCGTGA

Upstream 100 bases:

>100_bases
TGACGGCCGCAACCGGCACGCGCGGGCCGCAGTCGCGCAATCCGTTGCCGCGGCAGCGCCGCGGCGGCATTCGCAGTCAG
ACCAACCCAAGGAGACACAC

Downstream 100 bases:

>100_bases
GCGCGGCCGAACCGCGCGCAATGCAACGGCCGACACGGCGAACCGAACATTCCAGGAGACAGACATGGCAAGGAAGATCA
CTTATTCGCAGGCGATCAAC

Product: dehydrogenase E1 component

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSVSTQLSRDTLLEAYRLMRTIREFEERLHVEFATGEIPGFVHLYAGEEASAVGTMLHLGVADYVATTHRGHGHCIAKGV
DVRGMMAEIYGKKTGVCHGKGGSMHIADLSMGMLGANGIVGAGGPLVCGAALAAKQKKTGGVGVCFFGDGASNQGVIFES
MNLASVWRLPAIFVAENNGYAEATSSSWSVATDNIADRANGFGMPGVIVDGFDFFAVHEALGEAVERARNGGGPTLVEVK
FSRYFGHFEGDAQTYRAPGEVQKLRDEKDCLKHFEARVVRAEVLTTDELRAVDAQVKALIDDAVAEAKAAPLPDAADLLT
DVYVSYP

Sequences:

>Translated_327_residues
MSVSTQLSRDTLLEAYRLMRTIREFEERLHVEFATGEIPGFVHLYAGEEASAVGTMLHLGVADYVATTHRGHGHCIAKGV
DVRGMMAEIYGKKTGVCHGKGGSMHIADLSMGMLGANGIVGAGGPLVCGAALAAKQKKTGGVGVCFFGDGASNQGVIFES
MNLASVWRLPAIFVAENNGYAEATSSSWSVATDNIADRANGFGMPGVIVDGFDFFAVHEALGEAVERARNGGGPTLVEVK
FSRYFGHFEGDAQTYRAPGEVQKLRDEKDCLKHFEARVVRAEVLTTDELRAVDAQVKALIDDAVAEAKAAPLPDAADLLT
DVYVSYP
>Mature_326_residues
SVSTQLSRDTLLEAYRLMRTIREFEERLHVEFATGEIPGFVHLYAGEEASAVGTMLHLGVADYVATTHRGHGHCIAKGVD
VRGMMAEIYGKKTGVCHGKGGSMHIADLSMGMLGANGIVGAGGPLVCGAALAAKQKKTGGVGVCFFGDGASNQGVIFESM
NLASVWRLPAIFVAENNGYAEATSSSWSVATDNIADRANGFGMPGVIVDGFDFFAVHEALGEAVERARNGGGPTLVEVKF
SRYFGHFEGDAQTYRAPGEVQKLRDEKDCLKHFEARVVRAEVLTTDELRAVDAQVKALIDDAVAEAKAAPLPDAADLLTD
VYVSYP

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=324, Percent_Identity=38.8888888888889, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI291084742, Length=326, Percent_Identity=38.6503067484663, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=38.6503067484663, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI291084744, Length=333, Percent_Identity=37.8378378378378, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI291084757, Length=326, Percent_Identity=34.6625766871166, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=27.7439024390244, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI258645172, Length=328, Percent_Identity=27.7439024390244, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17536047, Length=327, Percent_Identity=38.5321100917431, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI32564172, Length=327, Percent_Identity=38.5321100917431, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI86563355, Length=328, Percent_Identity=26.8292682926829, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI86563357, Length=328, Percent_Identity=26.8292682926829, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321026, Length=325, Percent_Identity=37.8461538461538, Blast_Score=211, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=38.6996904024768, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=38.6996904024768, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=38.6996904024768, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=39.5424836601307, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24639748, Length=323, Percent_Identity=38.390092879257, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=26.605504587156, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 34775; Mature: 34644

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTQLSRDTLLEAYRLMRTIREFEERLHVEFATGEIPGFVHLYAGEEASAVGTMLHLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCHHHHHHHHHHH
VADYVATTHRGHGHCIAKGVDVRGMMAEIYGKKTGVCHGKGGSMHIADLSMGMLGANGIV
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCEEECCCCCEEEEEHHHHHCCCCCCC
GAGGPLVCGAALAAKQKKTGGVGVCFFGDGASNQGVIFESMNLASVWRLPAIFVAENNGY
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCHHHHHCCCEEEEECCCCC
AEATSSSWSVATDNIADRANGFGMPGVIVDGFDFFAVHEALGEAVERARNGGGPTLVEVK
EEECCCCCCEECCCHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
FSRYFGHFEGDAQTYRAPGEVQKLRDEKDCLKHFEARVVRAEVLTTDELRAVDAQVKALI
EHHHCCCCCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DDAVAEAKAAPLPDAADLLTDVYVSYP
HHHHHHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SVSTQLSRDTLLEAYRLMRTIREFEERLHVEFATGEIPGFVHLYAGEEASAVGTMLHLG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCCHHHHHHHHHHH
VADYVATTHRGHGHCIAKGVDVRGMMAEIYGKKTGVCHGKGGSMHIADLSMGMLGANGIV
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCEEECCCCCEEEEEHHHHHCCCCCCC
GAGGPLVCGAALAAKQKKTGGVGVCFFGDGASNQGVIFESMNLASVWRLPAIFVAENNGY
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCHHHHHCCCEEEEECCCCC
AEATSSSWSVATDNIADRANGFGMPGVIVDGFDFFAVHEALGEAVERARNGGGPTLVEVK
EEECCCCCCEECCCHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
FSRYFGHFEGDAQTYRAPGEVQKLRDEKDCLKHFEARVVRAEVLTTDELRAVDAQVKALI
EHHHCCCCCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DDAVAEAKAAPLPDAADLLTDVYVSYP
HHHHHHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]