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The map label for this gene is msrA [H]

Identifier: 161523905

GI number: 161523905

Start: 797708

End: 798268

Strand: Direct

Name: msrA [H]

Synonym: Bmul_0725

Alternate gene names: 161523905

Gene position: 797708-798268 (Clockwise)

Preceding gene: 161523901

Following gene: 161523909

Centisome position: 23.13

GC content: 65.24

Gene sequence:

>561_bases
ATGGCGAACGAGATGCTTGAAACGGCGACGCTCGGAGGCGGGTGCTTCTGGTGCACGGAGGCCGTGTTTCTCGACGTGGA
CGGCGTGACGGCCGTGCAGTCCGGCTATGCGGGCGGTCATACGCGCAATCCGGGCTATCGCGACGTCTGCGACGGCGACA
CCGGTCACGCGGAAGTCGTCAACGTGACGTTCGACCCGTCGCGTATCGGCTACCGCGAGATTCTGGAAATCTTCTTCGCG
ACGCACGATCCGACGCAGCTGAACCGGCAGGGCAACGATGTCGGTACGCAGTACCGCTCGGTCGTGTTCACGCATTCGGA
CGCGCAGCGCGAGATCGCGCTCGACGTGATCCGCGAGCTCGAGCGCGAGCAGGTGTTCGGGCAGCCGATCGTCACCGAGG
TCGTGCCGCTCGACGGCAACTACTGGCCGGCCGAGGACTATCACCAGAACTATTACGCGCGCAATCCGGGGCAGGGCTAT
TGCGCGGTCGTGATCGGGCCGAAGCTCGCGAAGTTCCGCCAGAAGTTCGCGCACCGGCTGAAGTCGCAGCGCGGCGCGTA
A

Upstream 100 bases:

>100_bases
GCCGCAGCGGCCGTTGCGGACGGAAAGGGTCCGGAACGGCGAAACCGATCGGACGAGCCGGCGCGCATGCCGGCTGCGTT
CACTGACAGGAGTGGATTCG

Downstream 100 bases:

>100_bases
GCGGCGCCGCGCTCCGTTGTCGCGCGGCGCGCTCGCGCTACGCGGCTTCGCTGCGCCAGCGCGCGCAGGCCGCCGCGATC
TCGCGCGCGAGCGCGATGCA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MANEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDVCDGDTGHAEVVNVTFDPSRIGYREILEIFFA
THDPTQLNRQGNDVGTQYRSVVFTHSDAQREIALDVIRELEREQVFGQPIVTEVVPLDGNYWPAEDYHQNYYARNPGQGY
CAVVIGPKLAKFRQKFAHRLKSQRGA

Sequences:

>Translated_186_residues
MANEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDVCDGDTGHAEVVNVTFDPSRIGYREILEIFFA
THDPTQLNRQGNDVGTQYRSVVFTHSDAQREIALDVIRELEREQVFGQPIVTEVVPLDGNYWPAEDYHQNYYARNPGQGY
CAVVIGPKLAKFRQKFAHRLKSQRGA
>Mature_185_residues
ANEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDVCDGDTGHAEVVNVTFDPSRIGYREILEIFFAT
HDPTQLNRQGNDVGTQYRSVVFTHSDAQREIALDVIRELEREQVFGQPIVTEVVPLDGNYWPAEDYHQNYYARNPGQGYC
AVVIGPKLAKFRQKFAHRLKSQRGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=45.398773006135, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=45.398773006135, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=45.6140350877193, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=42.2077922077922, Blast_Score=130, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=32.8859060402685, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=43.125, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24664627, Length=167, Percent_Identity=31.7365269461078, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664631, Length=167, Percent_Identity=31.1377245508982, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=30.4347826086957, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20761; Mature: 20630

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDVCDGDTGHAEVV
CCCHHHHHHHCCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
NVTFDPSRIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSDAQREIALDVIREL
EEEECCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHH
EREQVFGQPIVTEVVPLDGNYWPAEDYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRL
HHHHHCCCCCHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
KSQRGA
HHHCCC
>Mature Secondary Structure 
ANEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDVCDGDTGHAEVV
CCHHHHHHHCCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
NVTFDPSRIGYREILEIFFATHDPTQLNRQGNDVGTQYRSVVFTHSDAQREIALDVIREL
EEEECCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHH
EREQVFGQPIVTEVVPLDGNYWPAEDYHQNYYARNPGQGYCAVVIGPKLAKFRQKFAHRL
HHHHHCCCCCHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
KSQRGA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]