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The map label for this gene is pcaK [H]

Identifier: 161523897

GI number: 161523897

Start: 789309

End: 790901

Strand: Direct

Name: pcaK [H]

Synonym: Bmul_0717

Alternate gene names: 161523897

Gene position: 789309-790901 (Clockwise)

Preceding gene: 161523896

Following gene: 161523901

Centisome position: 22.89

GC content: 72.0

Gene sequence:

>1593_bases
ATGGCCACGGCGCCGGATCGTCATCTCGCCTGGCACGAGGCTGGCGTGCGAGGCACAGGGTCCGCATCGGTGCCGCAGCG
CCGGCGCGGGCCGACCGGAAGCATCGGAGGGAGACAGGATGAAAGCACTCGATTGCCGCAGTTTCGCCGCGCATGGCCTG
CGCACGGTTGCGCCGCGCGCGGGATGGAGGCACGCATGAGCACGCGCGACGACGCCACCGCGCCCGCCGTCGACATCGGC
GCGACGCTCGACGACGGTCCGTTTACGATGATGCAGAAATGCGTGGTGCTGCTGGCCGCGCTCTCGATCGTGCTCGACGG
CTTCGACGGCCAGCTGATCGGCTTCGCGATTCCGGTGCTGATCAAGGAATGGGGCATCACGCGCGGCGCCTTCGCGCCGG
CCGTCGCGGCCGGGCTGATCGGGATGGGGATCGGCAGCGCCTGCGCGGGGCTCGTCGCCGACCGTTTCGGCCGGCGCGGC
GCGGTACTCGGCAGCGTGTTCCTGTTCGGCGCGGCGACCTGCGCGATCGGACTCGCGCACAACGTCGAGACGATCGCCGC
GCTGCGCTTCGTCGCCGGCCTCGGCATCGGCGGCGCATTGCCGACCGCGACCACGATGACCGCCGAATACACGCCCGCGC
GGCGCCGCACGATGATGGTCACCGCGACGATCGTCTGCGTGCCGCTCGGCGGCATGCTCGCCGGCCTGTTCGCGCACGAG
GTGCTGCCGCGCTACGGGTGGCGCACGCTGTTCTTCGCGGGCGGCGCGCTGCCGCTCGTGCTCGGCTTCGTGCTGGCGGC
GGCGTTGCCCGAATCGCCGCGCTACCTCGCGCGGCGTCCCGCACGCTGGGCCGAGCTCGGCGCGCTGCTGGCGCGCATGA
AGCGTCCGGTCGCGCCGGGCACCGTGTTCACCGATCTGAGGGACGCGCAGGCGCACGGCGGCAGCGGCGGGTTCCGCTCG
CTGTTCGCGGGCGGCCAGGCGCGCGACACGATCGCGCTGTGGTGCGCGTTCTTCATGTGTCTGCTCGCCGTGTATGCGGC
CTTCAGCTGGCTGCCGACGATGCTCGCCGCGAGCGGGCTCAGCGTGTCGGTCGCAGGCGCGGGGCTCACCGCATACAACC
TCGGCGGCGTGATCGGCGCGCTGCTGTGCGCATGGACGATCGCGCGTGTCGGTTCGCGCTGGCCGCTCGTACTGTGCAGC
GTCGGCGGCGCGGCGAGCGCGCTGTGGCTGATGAGTGTCGATGCGGGCAGCCATACGCGCTGGCTGATCGTCGGCCTCGG
CGCGCACGGCCTGTTCGTCAACGCGGTGCAGTCGACGATGTATGCGCTGTGCGCGTACATCTATCCGACGGCCGTGCGCG
CGACCGGCACCGCGAGCGCGCTCGCGTTCGGCCGGCTCGGTGCGATTCTCAGTGCGTTCGCCGGTGCGTTCGTGATCACG
ACGGGCGGCGCGACCGCGTATCTGACGATGCTGGCGGCCGCGATGGGCATCGTCTGCGTCGCGCTGCTGGTCGTGCGGCG
GCATATCCCTAAGCTGTCGCGCGAGCCGGCGCAGCCGCGCGAGCGGGAGGAGCTGGTTCGCACGTCGTCGTGA

Upstream 100 bases:

>100_bases
AACGATGCTGAGCCTGGTGCGCGTGATCGACGCGCAAGCAGGCTGAGCGTCATGCCGGCGGCCGGCTTGCGCCGCGCGAC
GAGACACAAGAGCGCCGGGC

Downstream 100 bases:

>100_bases
CGGCGCGTAGCGCGCATGCATTGCGCATTCGCGCTGCTTGCCCGATGCCGCAGGGTCCCGCCGGGCGGCGCGAGCTTCAC
GCGTTACAGCGTCGTGCGCA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MATAPDRHLAWHEAGVRGTGSASVPQRRRGPTGSIGGRQDESTRLPQFRRAWPAHGCAARGMEARMSTRDDATAPAVDIG
ATLDDGPFTMMQKCVVLLAALSIVLDGFDGQLIGFAIPVLIKEWGITRGAFAPAVAAGLIGMGIGSACAGLVADRFGRRG
AVLGSVFLFGAATCAIGLAHNVETIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHE
VLPRYGWRTLFFAGGALPLVLGFVLAAALPESPRYLARRPARWAELGALLARMKRPVAPGTVFTDLRDAQAHGGSGGFRS
LFAGGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGAGLTAYNLGGVIGALLCAWTIARVGSRWPLVLCS
VGGAASALWLMSVDAGSHTRWLIVGLGAHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAFVIT
TGGATAYLTMLAAAMGIVCVALLVVRRHIPKLSREPAQPREREELVRTSS

Sequences:

>Translated_530_residues
MATAPDRHLAWHEAGVRGTGSASVPQRRRGPTGSIGGRQDESTRLPQFRRAWPAHGCAARGMEARMSTRDDATAPAVDIG
ATLDDGPFTMMQKCVVLLAALSIVLDGFDGQLIGFAIPVLIKEWGITRGAFAPAVAAGLIGMGIGSACAGLVADRFGRRG
AVLGSVFLFGAATCAIGLAHNVETIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHE
VLPRYGWRTLFFAGGALPLVLGFVLAAALPESPRYLARRPARWAELGALLARMKRPVAPGTVFTDLRDAQAHGGSGGFRS
LFAGGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGAGLTAYNLGGVIGALLCAWTIARVGSRWPLVLCS
VGGAASALWLMSVDAGSHTRWLIVGLGAHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAFVIT
TGGATAYLTMLAAAMGIVCVALLVVRRHIPKLSREPAQPREREELVRTSS
>Mature_529_residues
ATAPDRHLAWHEAGVRGTGSASVPQRRRGPTGSIGGRQDESTRLPQFRRAWPAHGCAARGMEARMSTRDDATAPAVDIGA
TLDDGPFTMMQKCVVLLAALSIVLDGFDGQLIGFAIPVLIKEWGITRGAFAPAVAAGLIGMGIGSACAGLVADRFGRRGA
VLGSVFLFGAATCAIGLAHNVETIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHEV
LPRYGWRTLFFAGGALPLVLGFVLAAALPESPRYLARRPARWAELGALLARMKRPVAPGTVFTDLRDAQAHGGSGGFRSL
FAGGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGAGLTAYNLGGVIGALLCAWTIARVGSRWPLVLCSV
GGAASALWLMSVDAGSHTRWLIVGLGAHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAFVITT
GGATAYLTMLAAAMGIVCVALLVVRRHIPKLSREPAQPREREELVRTSS

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=499, Percent_Identity=23.2464929859719, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI166064021, Length=367, Percent_Identity=28.0653950953678, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI203098995, Length=188, Percent_Identity=31.9148936170213, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081723, Length=334, Percent_Identity=32.0359281437126, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87082159, Length=392, Percent_Identity=27.0408163265306, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786229, Length=439, Percent_Identity=24.373576309795, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87082231, Length=184, Percent_Identity=31.5217391304348, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082404, Length=378, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788068, Length=453, Percent_Identity=22.7373068432671, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788074, Length=370, Percent_Identity=23.2432432432432, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789152, Length=401, Percent_Identity=22.6932668329177, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790463, Length=359, Percent_Identity=25.0696378830084, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789207, Length=189, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=427, Percent_Identity=24.3559718969555, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19922874, Length=416, Percent_Identity=25.2403846153846, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668456, Length=348, Percent_Identity=29.0229885057471, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24649622, Length=355, Percent_Identity=26.1971830985915, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55102; Mature: 54971

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAPDRHLAWHEAGVRGTGSASVPQRRRGPTGSIGGRQDESTRLPQFRRAWPAHGCAAR
CCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHC
GMEARMSTRDDATAPAVDIGATLDDGPFTMMQKCVVLLAALSIVLDGFDGQLIGFAIPVL
CCHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IKEWGITRGAFAPAVAAGLIGMGIGSACAGLVADRFGRRGAVLGSVFLFGAATCAIGLAH
HHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NVETIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHE
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEHEEHHHHHHHHHHHHHHHHHHH
VLPRYGWRTLFFAGGALPLVLGFVLAAALPESPRYLARRPARWAELGALLARMKRPVAPG
HHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCC
TVFTDLRDAQAHGGSGGFRSLFAGGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGL
HHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVSVAGAGLTAYNLGGVIGALLCAWTIARVGSRWPLVLCSVGGAASALWLMSVDAGSHTR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHEEEEEEECCCCCCE
WLIVGLGAHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAFVIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEE
TGGATAYLTMLAAAMGIVCVALLVVRRHIPKLSREPAQPREREELVRTSS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ATAPDRHLAWHEAGVRGTGSASVPQRRRGPTGSIGGRQDESTRLPQFRRAWPAHGCAAR
CCCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHC
GMEARMSTRDDATAPAVDIGATLDDGPFTMMQKCVVLLAALSIVLDGFDGQLIGFAIPVL
CCHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IKEWGITRGAFAPAVAAGLIGMGIGSACAGLVADRFGRRGAVLGSVFLFGAATCAIGLAH
HHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NVETIAALRFVAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHE
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEHEEHHHHHHHHHHHHHHHHHHH
VLPRYGWRTLFFAGGALPLVLGFVLAAALPESPRYLARRPARWAELGALLARMKRPVAPG
HHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCC
TVFTDLRDAQAHGGSGGFRSLFAGGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGL
HHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVSVAGAGLTAYNLGGVIGALLCAWTIARVGSRWPLVLCSVGGAASALWLMSVDAGSHTR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHEEEEEEECCCCCCE
WLIVGLGAHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAFVIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEE
TGGATAYLTMLAAAMGIVCVALLVVRRHIPKLSREPAQPREREELVRTSS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]