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The map label for this gene is apbA [H]

Identifier: 161523896

GI number: 161523896

Start: 788322

End: 789254

Strand: Direct

Name: apbA [H]

Synonym: Bmul_0716

Alternate gene names: 161523896

Gene position: 788322-789254 (Clockwise)

Preceding gene: 161523895

Following gene: 161523897

Centisome position: 22.86

GC content: 71.06

Gene sequence:

>933_bases
ATGAGAATCGCGATTCTGGGCGCGGGCGCGATGGGCTCGCTGTTCGGCGGCCTGCTTGCGGAAAGCGGCGAGGACGTCAC
GCTGATCGACGTCAACGACGCGCATCTCGACGCGATTCGTCGCGACGGGCTGCGCATCGACGACGACCGCGGCGAGCGCC
ACATCACGACCTTGCAGGCGCTGCGGCCCGAGGCCGCGAATGCGTCGGCCGACACACCGTCCGATCTGCTGATCGTCTTC
ACGAAGTCGCTGCATACGCGCGTCGCACTCGACGGCGTGCGCGCACTGCTGACGCCGCACACGCATGTGCTGACGCTGCA
GAACGGGCTCGGCAATGTCGAGACGCTCAACGCGTTCGTGCCGCTCGAGCGGATCCTCGTCGGCGTCACGACCTGGCCGG
CCGATCTGGCCGGGCCTGCGCACGTGCTCTCGCACGGCGCGGGCACGATCCGCATGATGACGGCCGACGGCGCGGCGAGC
CCGTTCGCGGCGGCGGTCGCCGACGCGCTGTCGCGCGCGGGGCTCGCCTGCACGCTCGATGCGGACGTGTGGGCCGCGAT
CTGGGAGAAGGTCGCGTTCAACGCGGCGCTCAACACGCTCTGCGCAGTGACGCGCCGCACCGTCGACCAGCTCGGCGAAC
ATCACGACGGGCCGCGCCTCGCGCACGCGATCGTCGCCGAGACGGCCGCCGTCGCGCGGGCGAAGGGCATCGCGGTCGAC
GCGGCGCGCATCGCACGCAACGTCGAGCATGCGATCCGCGAACATCGCGGTCATCGCCCGTCGATGCTGCAGGACGTACT
CGCGGGCCGCCGCACCGAGATCGACGCGATCGGCGGCAAGGTGGTCGCCGCCGCGCGCGAGGTCGGGCTGGCGGTCCCGC
ATACCGAAACGATGCTGAGCCTGGTGCGCGTGATCGACGCGCAAGCAGGCTGA

Upstream 100 bases:

>100_bases
CATTTCGGCGGCAAGGCCGGCATCGCGGCGTTCACGGACTTGCGCTGGATCACCGTGCAGACCGCGCCGCGTCACTATCC
GTTCTGAGAGGCCGCCGACC

Downstream 100 bases:

>100_bases
GCGTCATGCCGGCGGCCGGCTTGCGCCGCGCGACGAGACACAAGAGCGCCGGGCATGGCCACGGCGCCGGATCGTCATCT
CGCCTGGCACGAGGCTGGCG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRIAILGAGAMGSLFGGLLAESGEDVTLIDVNDAHLDAIRRDGLRIDDDRGERHITTLQALRPEAANASADTPSDLLIVF
TKSLHTRVALDGVRALLTPHTHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADLAGPAHVLSHGAGTIRMMTADGAAS
PFAAAVADALSRAGLACTLDADVWAAIWEKVAFNAALNTLCAVTRRTVDQLGEHHDGPRLAHAIVAETAAVARAKGIAVD
AARIARNVEHAIREHRGHRPSMLQDVLAGRRTEIDAIGGKVVAAAREVGLAVPHTETMLSLVRVIDAQAG

Sequences:

>Translated_310_residues
MRIAILGAGAMGSLFGGLLAESGEDVTLIDVNDAHLDAIRRDGLRIDDDRGERHITTLQALRPEAANASADTPSDLLIVF
TKSLHTRVALDGVRALLTPHTHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADLAGPAHVLSHGAGTIRMMTADGAAS
PFAAAVADALSRAGLACTLDADVWAAIWEKVAFNAALNTLCAVTRRTVDQLGEHHDGPRLAHAIVAETAAVARAKGIAVD
AARIARNVEHAIREHRGHRPSMLQDVLAGRRTEIDAIGGKVVAAAREVGLAVPHTETMLSLVRVIDAQAG
>Mature_310_residues
MRIAILGAGAMGSLFGGLLAESGEDVTLIDVNDAHLDAIRRDGLRIDDDRGERHITTLQALRPEAANASADTPSDLLIVF
TKSLHTRVALDGVRALLTPHTHVLTLQNGLGNVETLNAFVPLERILVGVTTWPADLAGPAHVLSHGAGTIRMMTADGAAS
PFAAAVADALSRAGLACTLDADVWAAIWEKVAFNAALNTLCAVTRRTVDQLGEHHDGPRLAHAIVAETAAVARAKGIAVD
AARIARNVEHAIREHRGHRPSMLQDVLAGRRTEIDAIGGKVVAAAREVGLAVPHTETMLSLVRVIDAQAG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=307, Percent_Identity=28.6644951140065, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32557; Mature: 32557

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAILGAGAMGSLFGGLLAESGEDVTLIDVNDAHLDAIRRDGLRIDDDRGERHITTLQA
CEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCEECCCCCCHHHHHHHH
LRPEAANASADTPSDLLIVFTKSLHTRVALDGVRALLTPHTHVLTLQNGLGNVETLNAFV
HCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
PLERILVGVTTWPADLAGPAHVLSHGAGTIRMMTADGAASPFAAAVADALSRAGLACTLD
HHHHHHHHHCCCCHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
ADVWAAIWEKVAFNAALNTLCAVTRRTVDQLGEHHDGPRLAHAIVAETAAVARAKGIAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHH
AARIARNVEHAIREHRGHRPSMLQDVLAGRRTEIDAIGGKVVAAAREVGLAVPHTETMLS
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHH
LVRVIDAQAG
HHHHHHCCCC
>Mature Secondary Structure
MRIAILGAGAMGSLFGGLLAESGEDVTLIDVNDAHLDAIRRDGLRIDDDRGERHITTLQA
CEEEEEECCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCEECCCCCCHHHHHHHH
LRPEAANASADTPSDLLIVFTKSLHTRVALDGVRALLTPHTHVLTLQNGLGNVETLNAFV
HCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
PLERILVGVTTWPADLAGPAHVLSHGAGTIRMMTADGAASPFAAAVADALSRAGLACTLD
HHHHHHHHHCCCCHHHCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
ADVWAAIWEKVAFNAALNTLCAVTRRTVDQLGEHHDGPRLAHAIVAETAAVARAKGIAVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHH
AARIARNVEHAIREHRGHRPSMLQDVLAGRRTEIDAIGGKVVAAAREVGLAVPHTETMLS
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCCCHHHHHH
LVRVIDAQAG
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]