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The map label for this gene is arlR

Identifier: 161509580

GI number: 161509580

Start: 1455557

End: 1456216

Strand: Reverse

Name: arlR

Synonym: USA300HOU_1350

Alternate gene names: 161509580

Gene position: 1456216-1455557 (Counterclockwise)

Preceding gene: 161509581

Following gene: 161509579

Centisome position: 50.69

GC content: 33.18

Gene sequence:

>660_bases
ATGACGCAAATTTTAATAGTAGAAGATGAACAAAACTTAGCAAGATTTCTTGAATTGGAACTCACACATGAAAATTACAA
TGTGGACACAGAGTATGATGGACAAGACGGTTTAGATAAAGCGCTTAGCCATTACTATGATTTAATCATATTAGATTTAA
TGTTGCCGTCAATTAATGGCTTAGAAATTTGTCGCAAAATTAGACAACAACAATCTACACCTATCATTATAATTACAGCG
AAAAGTGATACGTATGACAAAGTTGCTGGGCTTGATTACGGTGCAGACGATTATATAGTTAAGCCGTTTGATATTGAAGA
ACTTTTAGCAAGAATTCGTGCAATTTTACGTCGTCAGCCACAAAAGGATATTATCGATGTCAACGGTATTACAATTGATA
AGAACGCTTTTAAAGTGACGGTAAATGGCGCAGAAATTGAATTAACAAAAACAGAGTATGATTTACTATATCTTCTAGCT
GAAAATAAAAACCATGTTATGCAACGGGAACAAATTTTAAATCATGTATGGGGTTATAATAGTGAAGTAGAAACAAATGT
CGTAGATGTTTATATAAGATATTTACGAAACAAGTTAAAACCATACGATCGTGACAAAATGATTGAAACAGTTCGTGGCG
TTGGGTATGTGATACGATGA

Upstream 100 bases:

>100_bases
AACGTAAACAAACTAATTTAAAAAGCAACTATTGTATAGAAAAATACAAAATTTAAAATATATTACCTTATTAGAAAAAG
TCGTAATATGAGGTGTACAA

Downstream 100 bases:

>100_bases
CAAAACGTAAATTGCGCAATAACTGGATTATTGTTACCACGATGATTACGTTTGTCACGATATTTTTGTTTTGTTTAATT
ATTATTTTTTTCTTGAAAGA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITA
KSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLA
ENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR

Sequences:

>Translated_219_residues
MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITA
KSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLA
ENKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
>Mature_218_residues
TQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSINGLEICRKIRQQQSTPIIIITAK
SDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQPQKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAE
NKNHVMQREQILNHVWGYNSEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=40.9302325581395, Blast_Score=173, Evalue=9e-45,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=37.2727272727273, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=40.4545454545455, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=39.3665158371041, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=38.3561643835616, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.5454545454545, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.117903930131, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=33.6363636363636, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=34.2105263157895, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=31.5068493150685, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=32.3008849557522, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.2775330396476, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=29.535864978903, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=32.8358208955224, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=30.2752293577982, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): ARLR_STAA3 (Q2FH23)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494005.1
- HSSP:   P0A5Z4
- ProteinModelPortal:   Q2FH23
- SMR:   Q2FH23
- STRING:   Q2FH23
- EnsemblBacteria:   EBSTAT00000038345
- GeneID:   3914065
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1308
- eggNOG:   COG0745
- GeneTree:   EBGT00050000024053
- HOGENOM:   HBG753323
- OMA:   LPNINGL
- ProtClustDB:   CLSK885337
- GO:   GO:0005737
- GO:   GO:0009405
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF46894 Bipartite_resp_reg_C-effector; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 25499; Mature: 25367

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50110 RESPONSE_REGULATORY; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSING
CCEEEEEECCHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
LEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQP
HHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
QKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYN
CCCEEECCCEEECCCEEEEEEECCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCC
SEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEECC
>Mature Secondary Structure 
TQILIVEDEQNLARFLELELTHENYNVDTEYDGQDGLDKALSHYYDLIILDLMLPSING
CEEEEEECCHHHHHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCH
LEICRKIRQQQSTPIIIITAKSDTYDKVAGLDYGADDYIVKPFDIEELLARIRAILRRQP
HHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
QKDIIDVNGITIDKNAFKVTVNGAEIELTKTEYDLLYLLAENKNHVMQREQILNHVWGYN
CCCEEECCCEEECCCEEEEEEECCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCC
SEVETNVVDVYIRYLRNKLKPYDRDKMIETVRGVGYVIR
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA