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The map label for this gene is arlS

Identifier: 161509579

GI number: 161509579

Start: 1454205

End: 1455560

Strand: Reverse

Name: arlS

Synonym: USA300HOU_1349

Alternate gene names: 161509579

Gene position: 1455560-1454205 (Counterclockwise)

Preceding gene: 161509580

Following gene: 161509578

Centisome position: 50.66

GC content: 29.2

Gene sequence:

>1356_bases
ATGACAAAACGTAAATTGCGCAATAACTGGATTATTGTTACCACGATGATTACGTTTGTCACGATATTTTTGTTTTGTTT
AATTATTATTTTTTTCTTGAAAGATACACTGCATAATAGTGAGCTTGATGATGCAGAACGAAGCTCAAGCGATATTAATA
ATTTATTTCATTCTAAGCCTGTTAAAGATATATCTGCATTAGACTTGAATGCATCTTTAGGTAATTTTCAAGAGATAATT
ATTTATGATGAGCATAATAATAAATTATTTGAGACATCGAATGATAACACAGTGAGAGTTGAACCAGGTTATGAACACCG
TTATTTTGACCGCGTAATAAAAAAACGCTATAAAGGCATTGAATATTTAATTATTAAAGAACCAATTACAACGCAAGATT
TCAAAGGGTATAGCTTGTTAATTCATTCACTAGAAAATTATGATAACATCGTAAAATCATTGTATATCATTGCGCTGGCA
TTTGGAGTGATTGCAACAATTATAACTGCCACAATCAGTTATGTATTTTCAACACAAATTACTAAACCGCTTGTCAGTTT
ATCAAATAAAATGATTGAGATTCGACGAGATGGTTTTCAAAATAAATTGCAATTAAATACAAATTATGAAGAAATAGATA
ATTTAGCAAATACGTTTAATGAGATGATGAGCCAAATTGAAGAATCATTTAATCAACAAAGACAATTTGTTGAAGATGCG
TCACATGAATTACGAACACCATTACAAATTATTCAAGGTCATTTAAATTTGATTCAGCGATGGGGAAAAAAAGACCCAGC
AGTATTAGAAGAATCGTTAAATATTTCTATTGAAGAAATGAATCGTATCATAAAATTAGTCGAAGAATTACTTGAATTGA
CTAAAGGAGATGTAAATGACATTTCTTCTGAAGCACAGACCGTGCATATTAATGATGAAATTCGCTCGCGAATACACTCA
TTAAAACAATTGCATCCTGATTATCAATTTGATACGGATCTGACATCTAAAAATCTAGAAATTAAAATGAAACCTCATCA
ATTCGAACAATTATTTTTAATCTTTATTGATAATGCAATCAAATATGATGTGAAGAATAAGAAAATTAAAGTTAAGACAA
GGTTAAAAAATAAGCAAAAAATAATTGAAATTACAGATCATGGAATTGGTATTCCAGAGGAAGATCAAGATTTCATTTTT
GATCGCTTTTATCGAGTGGATAAATCTCGTTCAAGAAGTCAAGGCGGTAATGGACTCGGATTATCTATTGCTCAAAAAAT
CATTCAATTAAACGGAGGATCGATTAAAATTAAAAGTGAAATTAACAAAGGAACAACGTTTAAAATCATATTTTAA

Upstream 100 bases:

>100_bases
ATGTCGTAGATGTTTATATAAGATATTTACGAAACAAGTTAAAACCATACGATCGTGACAAAATGATTGAAACAGTTCGT
GGCGTTGGGTATGTGATACG

Downstream 100 bases:

>100_bases
TCATGACTGAGACGTCAATCAAAGTCATAGGATCAATTTTTTAAGTACACATTAGCTGTGACTAATGTATAAGAACAACT
ATAAAACAAATAAACAGTGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEII
IYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALA
FGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDA
SHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHS
LKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIF
DRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF

Sequences:

>Translated_451_residues
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEII
IYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALA
FGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDA
SHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHS
LKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIF
DRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
>Mature_450_residues
TKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIII
YDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAF
GVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDAS
HELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSL
KQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFD
RFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786783, Length=388, Percent_Identity=25.5154639175258, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=27.1186440677966, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789149, Length=450, Percent_Identity=25.5555555555556, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=286, Percent_Identity=24.4755244755245, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788279, Length=304, Percent_Identity=24.0131578947368, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=25.8181818181818, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=24.113475177305, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=303, Percent_Identity=24.7524752475248, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=26.0504201680672, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=23.728813559322, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=27.0642201834862, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=26.3829787234043, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=321, Percent_Identity=22.1183800623053, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=242, Percent_Identity=25.6198347107438, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=23.6734693877551, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=26.890756302521, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=27.8969957081545, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLS_STAA3 (Q2FH24)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494004.1
- ProteinModelPortal:   Q2FH24
- STRING:   Q2FH24
- EnsemblBacteria:   EBSTAT00000036224
- GeneID:   3913274
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1307
- eggNOG:   COG0642
- GeneTree:   EBGT00050000023863
- HOGENOM:   HBG694527
- OMA:   HFSNTQM
- ProtClustDB:   CLSK885336
- GO:   GO:0009405
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 52401; Mature: 52270

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x160574b0)-; HASH(0x167acdc4)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKP
CCCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
VKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGI
CCCHHHEECCCCCCCCEEEEEEECCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCC
EYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQI
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDA
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVND
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHH
ISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAI
CCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHEEHHEECCHH
KYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLG
EECCCCCEEEEEEHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
LSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
HHHHHHHHHCCCCEEEEEECCCCCCEEEEEH
>Mature Secondary Structure 
TKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKP
CCCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
VKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGI
CCCHHHEECCCCCCCCEEEEEEECCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCC
EYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQI
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDA
HHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVND
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHH
ISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAI
CCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHEEHHEECCHH
KYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLG
EECCCCCEEEEEEHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
LSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
HHHHHHHHHCCCCEEEEEECCCCCCEEEEEH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA