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The map label for this gene is lpxC

Identifier: 161485717

GI number: 161485717

Start: 931474

End: 932385

Strand: Direct

Name: lpxC

Synonym: XAC0785

Alternate gene names: 161485717

Gene position: 931474-932385 (Clockwise)

Preceding gene: 77748549

Following gene: 21241557

Centisome position: 18.0

GC content: 62.72

Gene sequence:

>912_bases
ATGACCCAGCAACGCACTCTCAAGAACACCATTCGCGCCACCGGCGTCGGCCTGCACAGCGGCGACAAGGTGTACATGAC
GTTACGGCCGGCTCCGGTCGATCATGGCGTGGTGTTCCGACGGGTGGACCTGGAACCGGTCGTCGAAGTCCCCGCAGATG
CCGAACTGGTCACCGAGACCACGCTGTGCACCGGGCTGACCTGCAACGGCGCCAAGATCCAGACCGTCGAACATCTGATG
TCCGCGTTGGCGGGCCTGGGTGTGGACAACGTCATCGTCGAACTGTCCTCGGCCGAGTTGCCGATCATGGATGGCTCGTC
CGGCCCGTTCGTATTCCTGCTGCAGTCGGCAGGCATCGTCGAACAGAGCAAGCCCAAGCGCTTCATCCGGATCACGCAGA
CGGTGGAAGTGCGCGACGGCGACAAGGTGGCGCGCTTTGAGCCGTACGAAGGCTACAAGCTCGGCTTCACCATCGAATTC
AATCACCCGATGATTCCGGCCAAGCAGTCGCGCCAGGAAATCGAGTTTTCCACCTCGGCGTACGTCAAGGAAATCTCGCG
CGCGCGCACCTTCGGGTTCATGCGCGACCTCGAGTACATGCGCGAGCGCAATCTGGGCCTGGGCGGCTCGATGGACAATG
CCATCGTGCTGGACGAGTTCCGCGTGCTCAACGAGGACGGCCTGCGTTACACCAACGAATTCGTGCGGCACAAGATTCTG
GACGCCATCGGCGACCTGTATCTGGCTGGCGGCGCCATCCTCGGCGCCTACGAAGGCTTCAAATCCGGCCACGCCCTCAA
CAACAAACTGGTGCGTGCGCTGTTGGCCGACCAGGCCGCCTGGGAATGGGTCAGCTTCCCGGAAGGCACCGAGCAGCCGC
CGGTAACCTACGCCAGCCCTGTCTACGCTTGA

Upstream 100 bases:

>100_bases
TACGGTTGCCGTCACGCGCGACTTGTTAAAATTCGGATAATCTCAGCGGAATAGACAGCCGGTTCAGCGTCTGTCTGCAT
TGTTCATCCAGACTTCGCAT

Downstream 100 bases:

>100_bases
TGTCAGGGAATGCCCTGGTCGACGTTCGAAGTGTGAACCAGGTCGTATTTCGGGCCCGTTCTTAACATTTATTTAAGGCT
TCTCTAACTCCTGCGGGCCA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPVVEVPADAELVTETTLCTGLTCNGAKIQTVEHLM
SALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRITQTVEVRDGDKVARFEPYEGYKLGFTIEF
NHPMIPAKQSRQEIEFSTSAYVKEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA

Sequences:

>Translated_303_residues
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPVVEVPADAELVTETTLCTGLTCNGAKIQTVEHLM
SALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRITQTVEVRDGDKVARFEPYEGYKLGFTIEF
NHPMIPAKQSRQEIEFSTSAYVKEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA
>Mature_302_residues
TQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPVVEVPADAELVTETTLCTGLTCNGAKIQTVEHLMS
ALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRITQTVEVRDGDKVARFEPYEGYKLGFTIEFN
HPMIPAKQSRQEIEFSTSAYVKEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKILD
AIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=301, Percent_Identity=57.4750830564784, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_XANAC (Q8PPA3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641137.2
- ProteinModelPortal:   Q8PPA3
- SMR:   Q8PPA3
- GeneID:   1154856
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0785
- NMPDR:   fig|190486.1.peg.781
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   XAXO190486:XAC0785-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33505; Mature: 33373

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPVVEVPADAELVTET
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHCCCCCCCHHHHHH
TLCTGLTCNGAKIQTVEHLMSALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIV
HHHCCEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQSKPKRFIRITQTVEVRDGDKVARFEPYEGYKLGFTIEFNHPMIPAKQSRQEIEFSTSA
CCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCHHCHHHHHHHHHH
YVKEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHECCCCCCHHHHHHHHHHHH
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASP
HHHHHHHHHCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VYA
CCC
>Mature Secondary Structure 
TQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPVVEVPADAELVTET
CCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHCCCCCCCHHHHHH
TLCTGLTCNGAKIQTVEHLMSALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIV
HHHCCEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQSKPKRFIRITQTVEVRDGDKVARFEPYEGYKLGFTIEFNHPMIPAKQSRQEIEFSTSA
CCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCHHCHHHHHHHHHH
YVKEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHECCCCCCHHHHHHHHHHHH
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASP
HHHHHHHHHCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VYA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217