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The map label for this gene is kbl [C]

Identifier: 161376699

GI number: 161376699

Start: 593602

End: 594789

Strand: Direct

Name: kbl [C]

Synonym: SA0508

Alternate gene names: 161376699

Gene position: 593602-594789 (Clockwise)

Preceding gene: 15926226

Following gene: 15926229

Centisome position: 21.09

GC content: 34.09

Gene sequence:

>1188_bases
GTGGTTCAATCATTACATGAGTTTTTAGAGGAAAATATAAATTATCTAAAAGAAAATGGTTTGTATAATGAAATAGATAC
AATTGAAGGTGCAAACGGACCAGAAATCAAAATCAATGGGAAATCATACATTAACTTATCTTCAAATAATTATTTAGGAC
TAGCAACAAATGAAGATTTGAAATCAGCTGCAAAAGCAGCTATTGATACACATGGTGTAGGTGCAGGCGCTGTTCGTACA
ATCAATGGTACATTAGATTTACACGACGAATTAGAAGAAACACTAGCAAAATTTAAAGGAACAGAAGCTGCAATAGCTTA
TCAGTCAGGATTTAATTGTAATATGGCTGCTATTTCAGCTGTCATGAATAAAAATGATGCTATTTTATCAGATGAGCTTA
ATCATGCATCAATTATTGATGGATGTCGCTTATCTAAAGCTAAAATTATTCGAGTTAACCATTCAGACATGGATGATTTA
CGTGCGAAAGCAAAAGAAGCAGTTGAATCAGGTCAATACAATAAAGTGATGTATATCACTGATGGCGTTTTTAGTATGGA
TGGTGATGTGGCTAAATTACCTGAAATTGTAGAAATTGCAGAAGAATTTGGTTTATTAACTTATGTTGACGACGCTCATG
GTTCAGGTGTTATGGGTAAAGGCGCTGGTACGGTTAAACATTTTGGTTTACAAGATAAAATCGATTTCCAAATAGGTACG
CTTTCTAAAGCAATTGGTGTCGTTGGCGGCTATGTAGCAGGTACAAAAGAGTTAATAGATTGGTTAAAAGCACAATCACG
ACCATTCTTATTCTCTACATCATTAGCACCTGGGGATACCAAAGCAATAACTGAAGCAGTTAAAAAGTTAATGGATTCAA
CTGAATTACATGATAAATTATGGGACAATGCACAATATTTAAAAAATGGATTGTCAAAATTAGGATATGATACAGGTGAG
TCAGAAACTCCAATTACACCAGTAATTATTGGTGATGAAAAAACAACTCAAGAATTTAGTAAGCGTTTAAAAGACGAAGG
TGTCTATGTGAAATCTATCGTTTTCCCAACAGTACCAAGAGGTACAGGACGTGTAAGAAATATGCCTACAGCTGCACATA
CAAAAGACATGTTAGATGAAGCAATTGCGGCTTATGAAAAAGTAGGAAAAGAAATGAAGTTGATTTAA

Upstream 100 bases:

>100_bases
TTTGAGATATTTTATCTATGAATGATAAGGCTTTCAAGTTATGTAGAATTACTGTATGATAAAGGTATTACCAAACAATA
CTTAAGGGGGATTATATACT

Downstream 100 bases:

>100_bases
TATTTATTTATTTATTCCCACGGCAAATATTGTCGTGGGCTTTTTTTAATGTTTAGTTTATTAACAGTAAGTTCTTATAA
CAATGTTTAGTGCTCCCCAA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDLKSAAKAAIDTHGVGAGAVRT
INGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISAVMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDL
RAKAKEAVESGQYNKVMYITDGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGT
LSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGE
SETPITPVIIGDEKTTQEFSKRLKDEGVYVKSIVFPTVPRGTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMKLI

Sequences:

>Translated_395_residues
MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDLKSAAKAAIDTHGVGAGAVRT
INGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISAVMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDL
RAKAKEAVESGQYNKVMYITDGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGT
LSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGE
SETPITPVIIGDEKTTQEFSKRLKDEGVYVKSIVFPTVPRGTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMKLI
>Mature_395_residues
MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDLKSAAKAAIDTHGVGAGAVRT
INGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISAVMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDL
RAKAKEAVESGQYNKVMYITDGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGT
LSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMDSTELHDKLWDNAQYLKNGLSKLGYDTGE
SETPITPVIIGDEKTTQEFSKRLKDEGVYVKSIVFPTVPRGTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMKLI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=391, Percent_Identity=35.2941176470588, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI284448556, Length=417, Percent_Identity=33.0935251798561, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=35.6756756756757, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=32.7027027027027, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI83977440, Length=411, Percent_Identity=29.4403892944039, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI83977442, Length=411, Percent_Identity=29.4403892944039, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI83977444, Length=396, Percent_Identity=29.7979797979798, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4502025, Length=358, Percent_Identity=34.3575418994413, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI40316939, Length=358, Percent_Identity=34.3575418994413, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=31.4176245210728, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=40.7035175879397, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=34.1040462427746, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=40.6565656565657, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32566772, Length=364, Percent_Identity=32.1428571428571, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=30.6629834254144, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=30.6629834254144, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=268, Percent_Identity=28.7313432835821, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982625, Length=268, Percent_Identity=28.7313432835821, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320438, Length=374, Percent_Identity=32.3529411764706, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=389, Percent_Identity=30.5912596401028, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6323954, Length=259, Percent_Identity=30.8880308880309, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24662918, Length=395, Percent_Identity=36.9620253164557, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=31.7204301075269, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17137420, Length=354, Percent_Identity=34.7457627118644, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24653280, Length=329, Percent_Identity=25.8358662613982, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24653276, Length=329, Percent_Identity=25.8358662613982, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24653278, Length=329, Percent_Identity=25.8358662613982, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42892; Mature: 42892

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDL
CHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCHHH
KSAAKAAIDTHGVGAGAVRTINGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISA
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
VMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDLRAKAKEAVESGQYNKVMYIT
HHCCCCCEECCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGT
CCCEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCCEEHHH
LSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMDSTELHDKL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
WDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFSKRLKDEGVYVKSIVFPTVPR
HCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCC
GTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMKLI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVQSLHEFLEENINYLKENGLYNEIDTIEGANGPEIKINGKSYINLSSNNYLGLATNEDL
CHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCHHH
KSAAKAAIDTHGVGAGAVRTINGTLDLHDELEETLAKFKGTEAAIAYQSGFNCNMAAISA
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
VMNKNDAILSDELNHASIIDGCRLSKAKIIRVNHSDMDDLRAKAKEAVESGQYNKVMYIT
HHCCCCCEECCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGDVAKLPEIVEIAEEFGLLTYVDDAHGSGVMGKGAGTVKHFGLQDKIDFQIGT
CCCEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCCEEHHH
LSKAIGVVGGYVAGTKELIDWLKAQSRPFLFSTSLAPGDTKAITEAVKKLMDSTELHDKL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
WDNAQYLKNGLSKLGYDTGESETPITPVIIGDEKTTQEFSKRLKDEGVYVKSIVFPTVPR
HCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCC
GTGRVRNMPTAAHTKDMLDEAIAAYEKVGKEMKLI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA