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The map label for this gene is zwf [H]

Identifier: 160902594

GI number: 160902594

Start: 1213314

End: 1214876

Strand: Direct

Name: zwf [H]

Synonym: Pmob_1133

Alternate gene names: 160902594

Gene position: 1213314-1214876 (Clockwise)

Preceding gene: 160902589

Following gene: 160902595

Centisome position: 55.92

GC content: 33.46

Gene sequence:

>1563_bases
ATGGACCAAATAACAAAACATCTTTCAAGAAAAAATATTTGTGAAGAAATAAAACCCGGGGCCTCTTCCTTAATAATATT
TGGAGCCTCAGGAGATTTAACTTTTAGAAAATTAATCCCTTCTATATATACGTTGTTCAAAAAGAACCTTTTACCCAACG
AATTTTTCTTACTGGGAGTAGCTAGGTCTAAATTCACCGAGGAGGAATACCGCCAAGAAATAAAAAATAGATTATTGGAA
GAAAACGAAGATAACTTTATAATTTCAAAATTCATTGAAAAAGTCTTTTACATTTCAGGTTTCTACGACGATGATTCCCT
GTACCTGGATCTAAAAAATAAACTAAATTATTTAGATAAAGTTTTTAACACCCACGAAAATCATCTTTTTTATCTTTCAA
CACCTCCAAACGTCTATTTAGAAATAATTAAACGTTTGGGGAAGTTTAACTTGACCAAAGAAAGTGAAAATTCTTATTCA
AGAATAATAATAGAAAAACCTTTTGGCAGTAATTTTAACACATCCAAAGAATTAGACGAGGAACTTCATAAGTATCTAAA
TGAAACCCAAATATACAGAATTGATCATTATCTTGGTAAAGAGACCGTTCAAAATATAATGATGCTCAGATTTGCAAACA
TTGTTTTTGAACCCATATGGAATTACAAATACATAGATAACGTTCAGATAACTGTTGCTGAAACATTAGGCGTAGAACAT
AGGGCTGGATACTTTGAACAAGCTGGTTTATTAAGAGACATGTTTCAAAACCATATGATGCAGCTTTTAACTTTGGTAGC
TATGGAACCTCCTGCATCCCTTGAAGATACAAGCGTCAGGGACGAAAAAACAAAACTGTTGAAAGCTATAAGACCATTTG
AAAAAGAAAAAATAAACGAATACTTTGTAAGGGGCCAATATATTGAGGGAATGATCAATGGAAAAGAAGTTCCAGCTTAT
AAAGAAGAAAAGAATGTTAATCCAGACTCCTTTGTAGAAACATTTGTAGCGGCTAAATTTTTAATCGATAATTGGAGATG
GAGCGGGGTGCCTTTCTATTTAAGGGCAGGAAAAAGGTTGAAAAGAAAAGTTACAGAAATCGCCATAATCTTTAAAGACG
TCCCTCATTCGATATTTGCTAAAAACGATATAACCTTAGAGAAAAATGCTCTCATTTTAAATATACAACCAGATGAAGGA
TTTTCACTGAAGATCCAAGCCAAACAACCTGGCTCCAAGCTTTGTTTGAACACGCTAACCATGGATTTCAATTACGACGA
ATTCTTCAAATTCAAAGGTCCAGATGCTTATGAAAGGCTACTTTTGGATGCCATGTTGGGAGATCAAACACTTTTTGTAA
GAAGTGACGCTATGGAAATTTCATGGAAAATCTTCACCCCTGTTTTAGAAAAATGGGAAGAAGAAAAACACAATGGATTG
AGATTATACAAAGCTGGTACCTGGGGACCAAAAGAATCTTTTGAACTATTATCAAAAGACAACAGAAGTTGGCGTAACTT
AGACTTTGAAAGCGAGAATCTGTATGAAAGCAAAATTTTTTGA

Upstream 100 bases:

>100_bases
TGTTTTCAAAATTTTTGAATTCTAAAAAATCTGTTTAAAGTAGCTTTTAGTGTTTCTAAGGACAATAAAATATTCTATAG
AAAGAGGTGGACATTAGTAC

Downstream 100 bases:

>100_bases
TGATCCCGAAACGTTTCACAATGAAGCTGTAAATTTAATTTATAAGCTATATGAAGAGAGCATAGAAAAAAATAAACTAT
TCACCTTAATGCTCTCAGGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MDQITKHLSRKNICEEIKPGASSLIIFGASGDLTFRKLIPSIYTLFKKNLLPNEFFLLGVARSKFTEEEYRQEIKNRLLE
ENEDNFIISKFIEKVFYISGFYDDDSLYLDLKNKLNYLDKVFNTHENHLFYLSTPPNVYLEIIKRLGKFNLTKESENSYS
RIIIEKPFGSNFNTSKELDEELHKYLNETQIYRIDHYLGKETVQNIMMLRFANIVFEPIWNYKYIDNVQITVAETLGVEH
RAGYFEQAGLLRDMFQNHMMQLLTLVAMEPPASLEDTSVRDEKTKLLKAIRPFEKEKINEYFVRGQYIEGMINGKEVPAY
KEEKNVNPDSFVETFVAAKFLIDNWRWSGVPFYLRAGKRLKRKVTEIAIIFKDVPHSIFAKNDITLEKNALILNIQPDEG
FSLKIQAKQPGSKLCLNTLTMDFNYDEFFKFKGPDAYERLLLDAMLGDQTLFVRSDAMEISWKIFTPVLEKWEEEKHNGL
RLYKAGTWGPKESFELLSKDNRSWRNLDFESENLYESKIF

Sequences:

>Translated_520_residues
MDQITKHLSRKNICEEIKPGASSLIIFGASGDLTFRKLIPSIYTLFKKNLLPNEFFLLGVARSKFTEEEYRQEIKNRLLE
ENEDNFIISKFIEKVFYISGFYDDDSLYLDLKNKLNYLDKVFNTHENHLFYLSTPPNVYLEIIKRLGKFNLTKESENSYS
RIIIEKPFGSNFNTSKELDEELHKYLNETQIYRIDHYLGKETVQNIMMLRFANIVFEPIWNYKYIDNVQITVAETLGVEH
RAGYFEQAGLLRDMFQNHMMQLLTLVAMEPPASLEDTSVRDEKTKLLKAIRPFEKEKINEYFVRGQYIEGMINGKEVPAY
KEEKNVNPDSFVETFVAAKFLIDNWRWSGVPFYLRAGKRLKRKVTEIAIIFKDVPHSIFAKNDITLEKNALILNIQPDEG
FSLKIQAKQPGSKLCLNTLTMDFNYDEFFKFKGPDAYERLLLDAMLGDQTLFVRSDAMEISWKIFTPVLEKWEEEKHNGL
RLYKAGTWGPKESFELLSKDNRSWRNLDFESENLYESKIF
>Mature_520_residues
MDQITKHLSRKNICEEIKPGASSLIIFGASGDLTFRKLIPSIYTLFKKNLLPNEFFLLGVARSKFTEEEYRQEIKNRLLE
ENEDNFIISKFIEKVFYISGFYDDDSLYLDLKNKLNYLDKVFNTHENHLFYLSTPPNVYLEIIKRLGKFNLTKESENSYS
RIIIEKPFGSNFNTSKELDEELHKYLNETQIYRIDHYLGKETVQNIMMLRFANIVFEPIWNYKYIDNVQITVAETLGVEH
RAGYFEQAGLLRDMFQNHMMQLLTLVAMEPPASLEDTSVRDEKTKLLKAIRPFEKEKINEYFVRGQYIEGMINGKEVPAY
KEEKNVNPDSFVETFVAAKFLIDNWRWSGVPFYLRAGKRLKRKVTEIAIIFKDVPHSIFAKNDITLEKNALILNIQPDEG
FSLKIQAKQPGSKLCLNTLTMDFNYDEFFKFKGPDAYERLLLDAMLGDQTLFVRSDAMEISWKIFTPVLEKWEEEKHNGL
RLYKAGTWGPKESFELLSKDNRSWRNLDFESENLYESKIF

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=505, Percent_Identity=39.2079207920792, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI108773793, Length=505, Percent_Identity=39.2079207920792, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI52145310, Length=514, Percent_Identity=27.2373540856031, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1788158, Length=490, Percent_Identity=40.4081632653061, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=41.5800415800416, Blast_Score=357, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=38.1742738589212, Blast_Score=330, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=36.7219917012448, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=36.7219917012448, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI221513548, Length=480, Percent_Identity=32.5, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 61131; Mature: 61131

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQITKHLSRKNICEEIKPGASSLIIFGASGDLTFRKLIPSIYTLFKKNLLPNEFFLLGV
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
ARSKFTEEEYRQEIKNRLLEENEDNFIISKFIEKVFYISGFYDDDSLYLDLKNKLNYLDK
HHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEECCCCEEEEHHHHHHHHHH
VFNTHENHLFYLSTPPNVYLEIIKRLGKFNLTKESENSYSRIIIEKPFGSNFNTSKELDE
HHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
ELHKYLNETQIYRIDHYLGKETVQNIMMLRFANIVFEPIWNYKYIDNVQITVAETLGVEH
HHHHHHCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEHHHHCCHH
RAGYFEQAGLLRDMFQNHMMQLLTLVAMEPPASLEDTSVRDEKTKLLKAIRPFEKEKINE
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
YFVRGQYIEGMINGKEVPAYKEEKNVNPDSFVETFVAAKFLIDNWRWSGVPFYLRAGKRL
HHHCCHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHH
KRKVTEIAIIFKDVPHSIFAKNDITLEKNALILNIQPDEGFSLKIQAKQPGSKLCLNTLT
HHHHHHHHHHHHHCCHHHHCCCCCEEECCEEEEEECCCCCCEEEEEECCCCCHHHHHHEE
MDFNYDEFFKFKGPDAYERLLLDAMLGDQTLFVRSDAMEISWKIFTPVLEKWEEEKHNGL
ECCCHHHHEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCE
RLYKAGTWGPKESFELLSKDNRSWRNLDFESENLYESKIF
EEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MDQITKHLSRKNICEEIKPGASSLIIFGASGDLTFRKLIPSIYTLFKKNLLPNEFFLLGV
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
ARSKFTEEEYRQEIKNRLLEENEDNFIISKFIEKVFYISGFYDDDSLYLDLKNKLNYLDK
HHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEECCCCEEEEHHHHHHHHHH
VFNTHENHLFYLSTPPNVYLEIIKRLGKFNLTKESENSYSRIIIEKPFGSNFNTSKELDE
HHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
ELHKYLNETQIYRIDHYLGKETVQNIMMLRFANIVFEPIWNYKYIDNVQITVAETLGVEH
HHHHHHCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEHHHHCCHH
RAGYFEQAGLLRDMFQNHMMQLLTLVAMEPPASLEDTSVRDEKTKLLKAIRPFEKEKINE
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
YFVRGQYIEGMINGKEVPAYKEEKNVNPDSFVETFVAAKFLIDNWRWSGVPFYLRAGKRL
HHHCCHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHH
KRKVTEIAIIFKDVPHSIFAKNDITLEKNALILNIQPDEGFSLKIQAKQPGSKLCLNTLT
HHHHHHHHHHHHHCCHHHHCCCCCEEECCEEEEEECCCCCCEEEEEECCCCCHHHHHHEE
MDFNYDEFFKFKGPDAYERLLLDAMLGDQTLFVRSDAMEISWKIFTPVLEKWEEEKHNGL
ECCCHHHHEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCE
RLYKAGTWGPKESFELLSKDNRSWRNLDFESENLYESKIF
EEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]