Click here to switch to the map view.

The map label for this gene is nagC [H]

Identifier: 160902321

GI number: 160902321

Start: 903433

End: 904590

Strand: Direct

Name: nagC [H]

Synonym: Pmob_0855

Alternate gene names: 160902321

Gene position: 903433-904590 (Clockwise)

Preceding gene: 160902320

Following gene: 160902322

Centisome position: 41.64

GC content: 36.18

Gene sequence:

>1158_bases
ATGAAAAAAGCATCCTTGTCTTCTTTAAAAGAAAACAATGCGGCACTTATTTTTCAATCATTAAGGATTCAAGGCCCTAT
GACAAGGGCTGAAATTGCAAGAGAAACACGCCTCATGCCTTCAACTGTGAGTTATATAACGAATCTTTTAATTCATAAAA
AGGTATTGAAAGAAGTTGGAAGTGAAGACGTTTCTCGTGTAGGGAAAAAGGGTATTTTGCTTGATATAAACTACGATGAC
TTCTTGTTTATTGGATATGACGTGGGCTCTGCATATTCAAGGGTTATTGTTTCAAACGGGAAGGGGGACATCTTATATTC
CAAAAGATTCGTCTCAGAGAAAAACGACAAATTGTTGAAGCAGATTTATGAAAATATAAAAATGGTTAAAAACAAATTCA
ACATAATCGGTATAGGTATGGCTTTTCCTGGTTATATAGATCCAGAAAACGGAGTGGTTATAAGATCTCACAATATTGAT
ATATCGAACTTTGAGGTTAAAAAGGTGATGAAAAAAGAGTTCAACCTACCAGCCTACGTGGATCATAACACAATAATGAT
GGCACGGAACTTAATTTCTAACAATTCCCACAAAGAGAAAGATTTTTGTGTGATCAACATTGGCCCAGGTATAGGAGTGG
GGATAGTAAGCAACGGAAAGATATTGAGAGGATATAAGAACGCTGCTGGGGAGTTAGGTCATGTGACGGTTAACCCCGAA
GGAAGAAAGTGTAACTGCGGTAAAAATGGTTGTTTGGAAACAGAAAGCTCAAGTAAGGCGATTGTTAGAAATTACGAAGA
AATATCCGGGAAAAATTTAGAGTGTGAAGGAAGTTGTGAATCGAAATTGGTATATGAATTAGCCAAAAAAGGTGATGAAA
ATGCGATAAAAGCATTTGAAAGGGCGGGAAAATATTTAGGAATTGGCATTGCTACTTTAGTCAATATCTTAAATCCAGAA
AAGGTCTATATAGCAGGTGGGGTGTCAAACGGGTGGGAATTTCTAAAAGACTCTACAGAACAAAGTTACAACCAGCATAT
ATTTTACGCAAACAAAGATGTAACTATTGAAGTTTCTTCGATAGGAGAATACATAACAGCTTGTGGAGCTGCGACTTATG
CCTTTGAAAAATATGTAAGAGAAGAATTAATACCATGA

Upstream 100 bases:

>100_bases
AGCATTTGATTTGGTGAGAGATATTAGTTATTTTAGACCAAAAAGGTTGTTTTTTGAAAAAATTTAGATAAAAATTATTG
AACTCGGAGGTACCAAGTCG

Downstream 100 bases:

>100_bases
GGAGGAAAATATAAATGTTTACAATTTTACCGAAGAAAGGGATTTCTTTGGGTCTTGGGGATAGAATAGGAATTGCAACC
CCGGGCCATATAAAAGTTGC

Product: ROK family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKKASLSSLKENNAALIFQSLRIQGPMTRAEIARETRLMPSTVSYITNLLIHKKVLKEVGSEDVSRVGKKGILLDINYDD
FLFIGYDVGSAYSRVIVSNGKGDILYSKRFVSEKNDKLLKQIYENIKMVKNKFNIIGIGMAFPGYIDPENGVVIRSHNID
ISNFEVKKVMKKEFNLPAYVDHNTIMMARNLISNNSHKEKDFCVINIGPGIGVGIVSNGKILRGYKNAAGELGHVTVNPE
GRKCNCGKNGCLETESSSKAIVRNYEEISGKNLECEGSCESKLVYELAKKGDENAIKAFERAGKYLGIGIATLVNILNPE
KVYIAGGVSNGWEFLKDSTEQSYNQHIFYANKDVTIEVSSIGEYITACGAATYAFEKYVREELIP

Sequences:

>Translated_385_residues
MKKASLSSLKENNAALIFQSLRIQGPMTRAEIARETRLMPSTVSYITNLLIHKKVLKEVGSEDVSRVGKKGILLDINYDD
FLFIGYDVGSAYSRVIVSNGKGDILYSKRFVSEKNDKLLKQIYENIKMVKNKFNIIGIGMAFPGYIDPENGVVIRSHNID
ISNFEVKKVMKKEFNLPAYVDHNTIMMARNLISNNSHKEKDFCVINIGPGIGVGIVSNGKILRGYKNAAGELGHVTVNPE
GRKCNCGKNGCLETESSSKAIVRNYEEISGKNLECEGSCESKLVYELAKKGDENAIKAFERAGKYLGIGIATLVNILNPE
KVYIAGGVSNGWEFLKDSTEQSYNQHIFYANKDVTIEVSSIGEYITACGAATYAFEKYVREELIP
>Mature_385_residues
MKKASLSSLKENNAALIFQSLRIQGPMTRAEIARETRLMPSTVSYITNLLIHKKVLKEVGSEDVSRVGKKGILLDINYDD
FLFIGYDVGSAYSRVIVSNGKGDILYSKRFVSEKNDKLLKQIYENIKMVKNKFNIIGIGMAFPGYIDPENGVVIRSHNID
ISNFEVKKVMKKEFNLPAYVDHNTIMMARNLISNNSHKEKDFCVINIGPGIGVGIVSNGKILRGYKNAAGELGHVTVNPE
GRKCNCGKNGCLETESSSKAIVRNYEEISGKNLECEGSCESKLVYELAKKGDENAIKAFERAGKYLGIGIATLVNILNPE
KVYIAGGVSNGWEFLKDSTEQSYNQHIFYANKDVTIEVSSIGEYITACGAATYAFEKYVREELIP

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=295, Percent_Identity=25.4237288135593, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI298566325, Length=295, Percent_Identity=25.4237288135593, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI190014632, Length=295, Percent_Identity=25.4237288135593, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4885285, Length=295, Percent_Identity=25.4237288135593, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786891, Length=374, Percent_Identity=27.2727272727273, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787878, Length=390, Percent_Identity=22.8205128205128, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI87082127, Length=330, Percent_Identity=25.1515151515152, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87081733, Length=307, Percent_Identity=26.7100977198697, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790522, Length=307, Percent_Identity=23.4527687296417, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787363, Length=304, Percent_Identity=21.0526315789474, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 42689; Mature: 42689

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKASLSSLKENNAALIFQSLRIQGPMTRAEIARETRLMPSTVSYITNLLIHKKVLKEVG
CCCCCHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
SEDVSRVGKKGILLDINYDDFLFIGYDVGSAYSRVIVSNGKGDILYSKRFVSEKNDKLLK
CHHHHHHCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCCCEEEEHHHHCCCHHHHHH
QIYENIKMVKNKFNIIGIGMAFPGYIDPENGVVIRSHNIDISNFEVKKVMKKEFNLPAYV
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEE
DHNTIMMARNLISNNSHKEKDFCVINIGPGIGVGIVSNGKILRGYKNAAGELGHVTVNPE
CCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCEEEECCHHCCCCCCEEEECCC
GRKCNCGKNGCLETESSSKAIVRNYEEISGKNLECEGSCESKLVYELAKKGDENAIKAFE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHH
RAGKYLGIGIATLVNILNPEKVYIAGGVSNGWEFLKDSTEQSYNQHIFYANKDVTIEVSS
HCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHCHHHHCCCCEEEEECCCEEEEHHH
IGEYITACGAATYAFEKYVREELIP
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKASLSSLKENNAALIFQSLRIQGPMTRAEIARETRLMPSTVSYITNLLIHKKVLKEVG
CCCCCHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
SEDVSRVGKKGILLDINYDDFLFIGYDVGSAYSRVIVSNGKGDILYSKRFVSEKNDKLLK
CHHHHHHCCCCEEEEECCCCEEEEEEECCCCEEEEEEECCCCCEEEEHHHHCCCHHHHHH
QIYENIKMVKNKFNIIGIGMAFPGYIDPENGVVIRSHNIDISNFEVKKVMKKEFNLPAYV
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEE
DHNTIMMARNLISNNSHKEKDFCVINIGPGIGVGIVSNGKILRGYKNAAGELGHVTVNPE
CCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCEEEECCHHCCCCCCEEEECCC
GRKCNCGKNGCLETESSSKAIVRNYEEISGKNLECEGSCESKLVYELAKKGDENAIKAFE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHH
RAGKYLGIGIATLVNILNPEKVYIAGGVSNGWEFLKDSTEQSYNQHIFYANKDVTIEVSS
HCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHCHHHHCCCCEEEEECCCEEEEHHH
IGEYITACGAATYAFEKYVREELIP
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]