Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 160901803

GI number: 160901803

Start: 344052

End: 345371

Strand: Direct

Name: ffh [H]

Synonym: Pmob_0319

Alternate gene names: 160901803

Gene position: 344052-345371 (Clockwise)

Preceding gene: 160901802

Following gene: 160901804

Centisome position: 15.86

GC content: 35.3

Gene sequence:

>1320_bases
ATGTTTGAAAACTTACAAAAAAAGCTGACAGGAGTCTTCAAGAACCTATCGGGTAAAGGAAAATTATCCGAAAAAAATAT
AAAAGATGCTGTTAGAGAAGTGAAACTTTCTCTTTTGGAAGCAGACGTTCACTATAAAGTGGTAAAAGAACTGATTGACA
GAGTCAAAGAAGAAGCAATTGGATCTAAGGTTCTCGAAAGTTTAACCCCTGATCAAGAATTTATCAGAATAGTTAGAGAC
GATTTAATAGAATTGATGGGTGGTAAAGAAAACAATAAAATTACCATTTCTCGTAATCCAGGTTTTATAATGCTTACGGG
TTTGCAAGGAAGCGGTAAAACATCAACCGCCGCTAAGTTAGCAAATTTTTATAAGAAAAAAGGAAAAAACCCTTTGTTAG
TTGCTGCCGATACTTACAGACCAGCGGCTATCGATCAACTTGTACAGTTGGGTGAGGATATTGGCATTCCCGTTTTTACT
GGTGACAGAGTAAACGCTTTGAAAATTATAGAAGAAAGTAAAAAATATGCAGAAAAGCTTTTGCATGATATTGTTATTGT
AGATACCGCAGGGCGTTTACACATCGATGAAAAGATGATGGAAGAGCTAGAAAATATAAAAAAATTAATCAATCCTGATG
AAATTTTGATGGTTGTCGATTCAATGGTTGGTCAAGATGCAGTTAATTCAGCAAAAGAATTTAACGATAAATTGGATCTT
TCTGGTTTTGTTGTTTCAAAACTCGACGGTGATTCTCGAGGCGGGGTCATCATCTCTATTAGGTACATAACTGGAAAACC
CGTCAAATTAGTTGGTGTTGGTGAGAAGATAGATGATTTGGAAGAGTTTTACCCAGATAGATATGTTGGAAGAATTTTGG
GAATGGGAGACGTACTTTCTTTCATAGAAAAAGTAGAACAAGATATAGATAAAAAGAAAGCAGAAGAAGATGCCGAAAGG
TTTATGGATGGAAAGTTTGATTTAAAAGACTTTCTCGAGCAAATTCGACAAATAAGAAAATTAGGGCCTCTAAGTAGTCT
TTTAGAAATGGTTCCTGGTGTCCCAAAGGAGCAAGTAGATGTAACAAAAGGTGAGCAAGAATTAAAAAAATTCGAGGCAA
TAATAAATTCAATGACCCCTAAGGAACGTAAAAACCCAGGAATACTTACTTATTCAAGAAAACAGCGGATAGCCAAGGGA
AGTGGGACAACTCTGCAAGATATTAACAGACTATTGAAATCATACGATCAACTGAAAAAAACTATGAAGCAAATGAAGAA
ACTAAAGGGCAGAAAACTAATGAACAATCTACCGTTTTGA

Upstream 100 bases:

>100_bases
TTATACCTCGTCTTCTACTTTTTTCATACTTTTTACCAAATTTCTTTCTTTTTATAGTATACTAAGGAAGGATTATTTTA
AGTCATGGGGTGAGCAAATA

Downstream 100 bases:

>100_bases
AATACCAATAATAATTAAAAATATATGGAGGTGTATTAATGGTAAAAATCAGATTGAACAGGATGGGAAGGAGACATCAA
CCGTTTTACAGAATAGTTAT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MFENLQKKLTGVFKNLSGKGKLSEKNIKDAVREVKLSLLEADVHYKVVKELIDRVKEEAIGSKVLESLTPDQEFIRIVRD
DLIELMGGKENNKITISRNPGFIMLTGLQGSGKTSTAAKLANFYKKKGKNPLLVAADTYRPAAIDQLVQLGEDIGIPVFT
GDRVNALKIIEESKKYAEKLLHDIVIVDTAGRLHIDEKMMEELENIKKLINPDEILMVVDSMVGQDAVNSAKEFNDKLDL
SGFVVSKLDGDSRGGVIISIRYITGKPVKLVGVGEKIDDLEEFYPDRYVGRILGMGDVLSFIEKVEQDIDKKKAEEDAER
FMDGKFDLKDFLEQIRQIRKLGPLSSLLEMVPGVPKEQVDVTKGEQELKKFEAIINSMTPKERKNPGILTYSRKQRIAKG
SGTTLQDINRLLKSYDQLKKTMKQMKKLKGRKLMNNLPF

Sequences:

>Translated_439_residues
MFENLQKKLTGVFKNLSGKGKLSEKNIKDAVREVKLSLLEADVHYKVVKELIDRVKEEAIGSKVLESLTPDQEFIRIVRD
DLIELMGGKENNKITISRNPGFIMLTGLQGSGKTSTAAKLANFYKKKGKNPLLVAADTYRPAAIDQLVQLGEDIGIPVFT
GDRVNALKIIEESKKYAEKLLHDIVIVDTAGRLHIDEKMMEELENIKKLINPDEILMVVDSMVGQDAVNSAKEFNDKLDL
SGFVVSKLDGDSRGGVIISIRYITGKPVKLVGVGEKIDDLEEFYPDRYVGRILGMGDVLSFIEKVEQDIDKKKAEEDAER
FMDGKFDLKDFLEQIRQIRKLGPLSSLLEMVPGVPKEQVDVTKGEQELKKFEAIINSMTPKERKNPGILTYSRKQRIAKG
SGTTLQDINRLLKSYDQLKKTMKQMKKLKGRKLMNNLPF
>Mature_439_residues
MFENLQKKLTGVFKNLSGKGKLSEKNIKDAVREVKLSLLEADVHYKVVKELIDRVKEEAIGSKVLESLTPDQEFIRIVRD
DLIELMGGKENNKITISRNPGFIMLTGLQGSGKTSTAAKLANFYKKKGKNPLLVAADTYRPAAIDQLVQLGEDIGIPVFT
GDRVNALKIIEESKKYAEKLLHDIVIVDTAGRLHIDEKMMEELENIKKLINPDEILMVVDSMVGQDAVNSAKEFNDKLDL
SGFVVSKLDGDSRGGVIISIRYITGKPVKLVGVGEKIDDLEEFYPDRYVGRILGMGDVLSFIEKVEQDIDKKKAEEDAER
FMDGKFDLKDFLEQIRQIRKLGPLSSLLEMVPGVPKEQVDVTKGEQELKKFEAIINSMTPKERKNPGILTYSRKQRIAKG
SGTTLQDINRLLKSYDQLKKTMKQMKKLKGRKLMNNLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=444, Percent_Identity=34.4594594594595, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=37.3913043478261, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI89061728, Length=125, Percent_Identity=39.2, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI295424842, Length=318, Percent_Identity=24.5283018867925, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI23308697, Length=318, Percent_Identity=24.5283018867925, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788963, Length=430, Percent_Identity=49.3023255813954, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1789874, Length=207, Percent_Identity=35.7487922705314, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=31.7351598173516, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=315, Percent_Identity=26.984126984127, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=389, Percent_Identity=34.7043701799486, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=310, Percent_Identity=29.0322580645161, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647949, Length=441, Percent_Identity=31.2925170068027, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24641198, Length=325, Percent_Identity=28, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49414; Mature: 49414

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLQKKLTGVFKNLSGKGKLSEKNIKDAVREVKLSLLEADVHYKVVKELIDRVKEEAI
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKVLESLTPDQEFIRIVRDDLIELMGGKENNKITISRNPGFIMLTGLQGSGKTSTAAKL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHH
ANFYKKKGKNPLLVAADTYRPAAIDQLVQLGEDIGIPVFTGDRVNALKIIEESKKYAEKL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHH
LHDIVIVDTAGRLHIDEKMMEELENIKKLINPDEILMVVDSMVGQDAVNSAKEFNDKLDL
HHHEEEEECCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCC
SGFVVSKLDGDSRGGVIISIRYITGKPVKLVGVGEKIDDLEEFYPDRYVGRILGMGDVLS
CCCEEEECCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHCHHHHHH
FIEKVEQDIDKKKAEEDAERFMDGKFDLKDFLEQIRQIRKLGPLSSLLEMVPGVPKEQVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHCC
VTKGEQELKKFEAIINSMTPKERKNPGILTYSRKQRIAKGSGTTLQDINRLLKSYDQLKK
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TMKQMKKLKGRKLMNNLPF
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFENLQKKLTGVFKNLSGKGKLSEKNIKDAVREVKLSLLEADVHYKVVKELIDRVKEEAI
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKVLESLTPDQEFIRIVRDDLIELMGGKENNKITISRNPGFIMLTGLQGSGKTSTAAKL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHH
ANFYKKKGKNPLLVAADTYRPAAIDQLVQLGEDIGIPVFTGDRVNALKIIEESKKYAEKL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHH
LHDIVIVDTAGRLHIDEKMMEELENIKKLINPDEILMVVDSMVGQDAVNSAKEFNDKLDL
HHHEEEEECCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCC
SGFVVSKLDGDSRGGVIISIRYITGKPVKLVGVGEKIDDLEEFYPDRYVGRILGMGDVLS
CCCEEEECCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHCHHHHHH
FIEKVEQDIDKKKAEEDAERFMDGKFDLKDFLEQIRQIRKLGPLSSLLEMVPGVPKEQVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHCC
VTKGEQELKKFEAIINSMTPKERKNPGILTYSRKQRIAKGSGTTLQDINRLLKSYDQLKK
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TMKQMKKLKGRKLMNNLPF
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]