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The map label for this gene is serA [H]

Identifier: 160901744

GI number: 160901744

Start: 276162

End: 277094

Strand: Direct

Name: serA [H]

Synonym: Pmob_0258

Alternate gene names: 160901744

Gene position: 276162-277094 (Clockwise)

Preceding gene: 160901743

Following gene: 160901745

Centisome position: 12.73

GC content: 33.87

Gene sequence:

>933_bases
ATGAAAATTCATATAAATGACCCTTTGGATGAAAATGCCTTAAAAAAATTACAAAACGAATTACCTGATCTTGAAATTAC
TTCGGAACACCTCGAAAAAGATGTCCTCAAAGATAAAATTAAAGAAATTGACGTATTAATTGTAAGAAGTGCAACTAAGG
TAACAAAAGAAATATTAGAACACGCAGATAAATTAAAGATTGTAGCAAGAGCGGGCATGGGATTAGATAATATAGATGTC
GATACTGCTAAATTGAAAGGAATAACCGTCTTAAATACGCCGGGCCAGAATTCTTTATCCGTTGCAGAATTGGTTATAGG
AATGGTTTTAGATATTTATCGGCACATTACAAGAGGGACGATCGGTTTAAAAAATGAACAATGGGAAAAAAAACAACTAG
AAGGATTTGAGTTGTCACAAAAAACCTTTGGTATCATCGGCTTTGGTTATGTAGGAAAAAATTTGGCACAATTACTAAAA
GGTTTTCAGACCAATACTCTGGTGTATGATGTTTTTGAAATAAGTGCAGAAGAGCAAAAGAATTATAACGTTAGACAGGT
ATCTTTGGAGGAGTTACTCCAAAATTCTGATATTATTTCTTTACATATTCCAAAAAACGAAAAAACTTATCACTTTATAA
GTGAACCCCAAATCAAAATGATGAAAGATGGTGCTGTAATAATTAATGCTGCAAGGGGAGGCGTCCTCGACGAGAATTAT
GTGCTTAAATATTTGAAAAATGGCAAGCTCCTTGGAGTAGGATTGGATGTTTTCGAAGAAGAACCTCCAAAAGGTGATTT
TTACAAGGAACTTTTTGCTTTACCAAATGTTGTCTTAACACCACATATAGGTGCTTCTACAAAAGAAGCGCAAGAACGAG
TGGGAATAAATATAGTAGACAGAGTGGTAGAAGAAGTTAAGAAACTTAACTGA

Upstream 100 bases:

>100_bases
TTTAGAAATGGCTTTTAACAAATTCGGCTTCGAAGTTGAACTTGGCAAAGGGGTAAAAGCTGCCGAAGAAGTTTTCATGA
AAGAGGGGGTTTAAATTACT

Downstream 100 bases:

>100_bases
CGAAATGAAGTTATATTTTCTTAAATCAATTTTTAAATTTAATTGAGTAGATTTATGGTATAATCAGATGGCTATAATTA
GCATATGTAACAGATAGCAA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKIHINDPLDENALKKLQNELPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILEHADKLKIVARAGMGLDNIDV
DTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLK
GFQTNTLVYDVFEISAEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENY
VLKYLKNGKLLGVGLDVFEEEPPKGDFYKELFALPNVVLTPHIGASTKEAQERVGINIVDRVVEEVKKLN

Sequences:

>Translated_310_residues
MKIHINDPLDENALKKLQNELPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILEHADKLKIVARAGMGLDNIDV
DTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLK
GFQTNTLVYDVFEISAEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENY
VLKYLKNGKLLGVGLDVFEEEPPKGDFYKELFALPNVVLTPHIGASTKEAQERVGINIVDRVVEEVKKLN
>Mature_310_residues
MKIHINDPLDENALKKLQNELPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILEHADKLKIVARAGMGLDNIDV
DTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLK
GFQTNTLVYDVFEISAEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENY
VLKYLKNGKLLGVGLDVFEEEPPKGDFYKELFALPNVVLTPHIGASTKEAQERVGINIVDRVVEEVKKLN

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=307, Percent_Identity=40.7166123778502, Blast_Score=237, Evalue=8e-63,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=264, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=34.2857142857143, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=34.2857142857143, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=34.0080971659919, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI6912396, Length=242, Percent_Identity=31.8181818181818, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=285, Percent_Identity=34.0350877192982, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=32.9457364341085, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1787645, Length=249, Percent_Identity=32.5301204819277, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788660, Length=228, Percent_Identity=32.8947368421053, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI87081824, Length=208, Percent_Identity=25.4807692307692, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=35.8552631578947, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147481, Length=265, Percent_Identity=29.811320754717, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=321, Percent_Identity=37.0716510903427, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320925, Length=321, Percent_Identity=36.1370716510903, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=33.9055793991416, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=259, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=158, Percent_Identity=30.379746835443, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=36.1842105263158, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=34.3283582089552, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=34.7169811320755, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=29.6153846153846, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24585514, Length=275, Percent_Identity=28.3636363636364, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=275, Percent_Identity=28.3636363636364, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552429, Length=275, Percent_Identity=28.3636363636364, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574284, Length=275, Percent_Identity=28.3636363636364, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=275, Percent_Identity=28.3636363636364, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=26.0714285714286, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571528, Length=301, Percent_Identity=28.9036544850498, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34811; Mature: 34811

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHINDPLDENALKKLQNELPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILE
CEEEECCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHH
HADKLKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGT
HHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
IGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEISAEEQK
CCCCCCCHHHHHCCCCCCCCHHCCEEEEHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHC
NYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENY
CCCCEEEEHHHHHCCCCEEEEEECCCCCCEEEECCCCEEEEECCEEEEEECCCCCCCHHH
VLKYLKNGKLLGVGLDVFEEEPPKGDFYKELFALPNVVLTPHIGASTKEAQERVGINIVD
HHHHHCCCCEEEECHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHCCCHHHH
RVVEEVKKLN
HHHHHHHHCC
>Mature Secondary Structure
MKIHINDPLDENALKKLQNELPDLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKEILE
CEEEECCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHH
HADKLKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRHITRGT
HHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
IGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEISAEEQK
CCCCCCCHHHHHCCCCCCCCHHCCEEEEHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHC
NYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGVLDENY
CCCCEEEEHHHHHCCCCEEEEEECCCCCCEEEECCCCEEEEECCEEEEEECCCCCCCHHH
VLKYLKNGKLLGVGLDVFEEEPPKGDFYKELFALPNVVLTPHIGASTKEAQERVGINIVD
HHHHHCCCCEEEECHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHHCCCHHHH
RVVEEVKKLN
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]